Increasing Numbers of Mast Cells in Skin Lesions of Hyperpigmented Mycosis Fungoides with Large-Cell Transformation

Kondo, Masateru; Igawa, Ken; Munetsugu, Takichi; Shibama, Sayaka; Nishizawa, Aya; Tokoro, Shown; Yokozeki, Hiroo

doi:10.5021/ad.2016.28.1.115

Cited by 4 publications

(4 citation statements)

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“…In humans, it appears that it is the chronic inflammation that causes the pigmentation, mostly in the monomorphic variant, although a link between the presence of MC and hyperpigmentation has been suggested, possibly owing to the secretion of stem cell factor by the MCs, stimulating the production of melanin by melanocytes. 21,22 Feline pigMPCM could be a chronic form of mMPCM. 1,3…”

Section: Discussionmentioning

confidence: 99%

Feline maculopapular cutaneous mastocytosis: a retrospective study of 13 cases and proposal for a new classification

Ngo¹,

Morren

Bodemer

et al. 2018

Journal of Feline Medicine and Surgery

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Case series summary Cutaneous mastocytosis is a disorder rarely reported in veterinary dermatology and usually described as 'urticaria pigmentosa'. This study aimed to evaluate the diagnosis, treatment and outcome of 13 affected cats, selected from the files of a private referral dermatology practice within a period of 14 years. Breeds of the affected individuals included Sphynx (n = 9), Devon Rex (n = 2) and Sphynx/Devon Rex crossbreeds (n = 2). Females (n = 9) were over-represented and the median duration of clinical signs prior to diagnosis was 8 months. The clinical presentation of these 13 cats was compared with cases reported in the veterinary literature and classified according to the current human consensus on cutaneous mastocytosis. Three clinical forms could be distinguished in cats: (1) large papular lesions and wheals, typically localised to the head, shoulders, ventral neck and axillae, and which may spontaneously resolve (termed polymorphic maculopapular cutaneous mastocytosis); (2) erythematous dermatitis, characterised by small maculopapular lesions often associated with crusts and with a poorer prognosis (termed monomorphic maculopapular cutaneous mastocytosis); and (3) more chronic dermatitis characterised by lichenification and hyperpigmentation, similar to the human condition 'urticaria pigmentosa' (termed pigmented maculopapular cutaneous mastocytosis). Histopathology was performed in eight cases and revealed a superficial-to-deep dermatitis characterised by infiltrates of mast cells and eosinophils. The response to various treatments, including antihistamines, steroids and ciclosporin, was variable. Relevance and novel information This article reports 13 new cases of feline cutaneous mastocytosis, confirming the clinical presentation and apparent breed predisposition. The feline maculopapular cutaneous mastocytosis seems to be clinically very close to the human form. This study proposes a new classification system for the feline disease based on the current human consensus, clinical presentation and prognosis, with three different subforms: polymorphic maculopapular cutaneous mastocytosis with eventual spontaneous regression; monomorphic maculopapular cutaneous mastocytosis with chronic evolution; and pigmented maculopapular cutaneous mastocytosis.

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Section: Discussionmentioning

confidence: 99%

Feline maculopapular cutaneous mastocytosis: a retrospective study of 13 cases and proposal for a new classification

Ngo¹,

Morren

Bodemer

et al. 2018

Journal of Feline Medicine and Surgery

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“…Hyperpigmented MF is an atypical clinical variant of cutaneous T‐cell lymphoma, which has been described in adults . Skin hyperpigmentation may be the sole manifestation, or it may coexist with other MF variants.…”

Section: Clinical Presentationmentioning

confidence: 99%

“…6 Hyperpigmented MF is an atypical clinical variant of cutaneous T-cell lymphoma, which has been described in adults. 27,28 Skin hyperpigmentation may be the sole manifestation, or it may coexist with other MF variants. In a series of 34 children with MF, 29% of patients were found to have hyperpigmented skin lesions.…”

Section: Prognosismentioning

confidence: 99%

Mycosis fungoides in pediatric patients: Clinical features, diagnostic challenges, and advances in therapeutic management

Cohen

Sweren

2019

Pediatric Dermatology

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Mycosis fungoides (MF) is the most common primary cutaneous lymphoma in pediatric patients. Given the indolent nature of MF, symptoms often present in childhood but may not be diagnosed as MF until adulthood. Delayed diagnosis is associated with poor long‐term prognosis. Thus, increased clinician recognition and accurate diagnosis of early‐stage MF in pediatric patients is critically important. In this review, we summarize the clinical features of the most common pediatric MF subtypes and highlight important differences between pediatric and adult MF. Moreover, we reviewed all pediatric MF case series published between 2008 and 2018 to analyze treatment modalities and identify emerging therapies. As treatment of pediatric MF is complex, selection of therapy varies significantly depending upon the specific clinical characteristics, disease severity, and patients' preferences.

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“…9 In contrast, hyperpigmented MF has been considered a relatively rare presentation of MF. 10 However, using only clinical and demographic information, we were able to identify 2 very different prognostic groups: those with hypopigmented lesions and those with only hyperpigmented and/or erythematous skin lesions. 11 In our retrospective review of 157 African American/Black MF patients at our institution-122 with early-stage and 35 with late-stage MF-45% of patients had hypopigmented lesions vs 52% with hyperpigmented and/or erythematous lesions but no hypopigmentation.…”

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confidence: 95%

Mycosis Fungoides in Black Patients: Time for a Better Look

Myskowski¹

2021

Cutis

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ecent advances in the immunopathogenesis and therapy of cutaneous T-cell lymphoma (CTCL) have shown great promise for the care of patients with mycosis fungoides (MF) and Sézary syndrome (SS). [1][2][3] Research into the tumor microenvironment, microbiome, and molecular genetics may yield further information as we strive to develop MF/SS therapy from the bench to the bedside. 3 Although progress has been made on multiple fronts in MF, some important-particularly epidemiologic and clinical-questions remain unanswered.Racial disparities are well known to exist in CTCLs, particularly MF and SS. [4][5][6][7] The incidence of MF and SS in the United States is higher in African American/Black patients than in White patients 4 ; in addition, MF has an earlier age at onset in Black patients compared with White patients. 4,5 Gender disparities also exist, with relatively more Black females than males affected with MF [4][5][6] ; in particular, early-onset MF (ie, <40 years of age) is more common in Black females than Black males. 6,7 According to Surveillance, Epidemiology, and End Results (SEER) data 4 and the US National Cancer Database, 5 African American/Black patients with MF have worse outcomes compared with other races (shorter overall survival and higher mortality) and also exhibit higher stages of disease at presentation (stage IIb or higher). 5 Black race also was found to be a predictor of poor overall survival after accounting for disease characteristics, socioeconomic factors, and types of treatment. The factors responsible for these racial disparities remain unclear.A fortuitous collision of interests and technology may have helped to shed light on some of the reasons for these racial disparities in MF. Nearly 2 decades ago, high-quality, whole-body digital cutaneous photography was implemented by the Dermatology Service at

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Increasing Numbers of Mast Cells in Skin Lesions of Hyperpigmented Mycosis Fungoides with Large-Cell Transformation

Cited by 4 publications

References 4 publications

Feline maculopapular cutaneous mastocytosis: a retrospective study of 13 cases and proposal for a new classification

Feline maculopapular cutaneous mastocytosis: a retrospective study of 13 cases and proposal for a new classification

Mycosis fungoides in pediatric patients: Clinical features, diagnostic challenges, and advances in therapeutic management

Mycosis Fungoides in Black Patients: Time for a Better Look

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