Increasing natural food folates through bioprocessing and biotechnology

Jägerstad, Margaretha; Piironen, Vieno; Walker, Caroline; Ros, Gaspar; Carnovale, E.; Holasová, M.; Nau, Heinz

doi:10.1016/j.tifs.2005.03.005

Cited by 66 publications

(48 citation statements)

References 11 publications

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“…This would mask the hematological abnormalities related to vitamin B 12 deficiency, delaying its diagnosis and allow the associated neurological dysfunction to progress to an irreversible combined degeneration of the spinal cord. Hereto, improving the bioavailability and intake of natural monoglutamyl folates could be an alternative to improve folate status, given that it is unlikely that natural vitamers would mask vitamin B 12 deficiency (Wright et al, 2001;Jagerstad et al, 2005) (Venn et al, 2002;Lamers et al, 2006) and on lowering tHcy (Venn et al, 2003;Lamers et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

L-ascorbic acid improves the serum folate response to an oral dose of [6S]-5-methyltetrahydrofolic acid in healthy men

et al. 2007

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Section: Introductionmentioning

confidence: 99%

L-ascorbic acid improves the serum folate response to an oral dose of [6S]-5-methyltetrahydrofolic acid in healthy men

et al. 2007

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“…It is reported that the use of folate-producing probiotic bacteria in combination with S. thermophilus and/or L. bulgaricus provides the largest increase in folate during the fermentation process of probiotic yoghurt compared to original milk and conventional fermented milk (Crittenden et al 2003;Jägerstad et al 2005;Rossi et al 2011).…”

Section: Folate Production In Milk and Yoghurtmentioning

confidence: 99%

Folate bio-fortification of yoghurt and fermented milk: a review

Rad

Khosroushahi

Khalili

et al. 2016

Dairy Sci. & Technol.

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Folate, an essential vitamin, plays an important role in human life for the synthesis of nucleotides, vitamins and some amino acid. This vitamin cannot be synthesized by humans and must be obtained exogenously to prevent folate deficiency, neural tube defects (NTDs) and other related diseases. Folic acid, the chemically synthesized form of folate, is used for fortification and supplementation, but it can cause adverse effects such as vitamin B 12 deficiency in high intake. Therefore, novel methods to increase concentrations of naturally occurring folate in foods have grabbed the interest of researchers. The application of bacterial cultures in food fermentation is a novel strategy to increase "natural" folate levels. Dairy products, especially yoghurt, are an appropriate choice for bio-fortification of folate as they contain folate-binding protein which improves folate bioavailability. This study will review the folate production by probiotic bacteria in fermented milk based on various strains and culture conditions.

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“…An important role of folate in normal bodily function is due to its biological properties (instability, sensitivity to temperature), which is an argument for promoting its supplementation. Dietary supplements of folic acid are particularly recommended for pregnant women [10]. The beneficial effects of folic acid in preventing disorders of embryogenesis, particularly neural tube defects, has been repeatedly confirmed.…”

Section: Journal Of Health Inequalities 2016 / Volume 2 / Issue 2 Dementioning

confidence: 99%

The significance of folate supplementation

Pisarska-Krawczyk¹,

Jarząbek-Bielecka²,

Bielecki³

2016

jhi

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Folates are pterin derivatives oxidised to various degrees, which exhibit the biological activity of folic acid. Physiologically, they act as coenzymes (cofactors) essential for ensuring normal metabolism, tissue renewal, and growth, particularly whenever any increasing demands arise due to accelerating cell division and metabolism. The importance of their role in organogenesis is widely recognised during pregnancy. The most common cause of folate deficiencies occurs when there are increased physiological demands for this compound, for instance: during pregnancy (especially in cases of having twins), gastrointestinal (GI) malabsorption of folate, congenital disorders of the GI tract, or if cytostatic medication has been given. Taking folate as a prophylactic measure also reduces rates of megaloblastic anaemia and neural tube defects.

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Increasing natural food folates through bioprocessing and biotechnology

Cited by 66 publications

References 11 publications

L-ascorbic acid improves the serum folate response to an oral dose of [6S]-5-methyltetrahydrofolic acid in healthy men

L-ascorbic acid improves the serum folate response to an oral dose of [6S]-5-methyltetrahydrofolic acid in healthy men

Folate bio-fortification of yoghurt and fermented milk: a review

The significance of folate supplementation

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