Increasing mortality associated with the more recent epidemic wave of hepatitis C virus infection in Northern Italy

Fedeli, Ugo

doi:10.1111/jvh.12893

Cited by 3 publications

(6 citation statements)

References 10 publications

(23 reference statements)

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“…Such second epidemic wave was confirmed by analyses of Italian death certificates, with an exponential increase of HCV-related mortality with age, and a further peak observed in the 50-54-year age-group especially among males [21]. This second wave can also explain the increase in HCV-related mortality observed from 2008-2012 to 2013–2016 among middle-aged males in the Veneto Region [6]. A similar finding was reported in the US, where HCV infection mostly affected baby boomers, and HCV-related mortality was steadily increasing [22].…”

Section: Discussionmentioning

confidence: 68%

“…However, several factors could reverse this favorable trend especially among young and middle-aged adults. An increase in HCV-related mortality among males aged 50–54 years has been recently reported in Northern Italy [6]. The role of HBV infection, in spite of very high vaccination coverage of the native population under 35 years, might increase due to massive immigration from countries with intermediate or high endemicity [7].…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of chronic liver disease among young/middle-aged adults in Northern Italy: role of hepatitis B and hepatitis C virus infection by age, sex, ethnicity

Fedeli

Avossa

Ferroni

et al. 2019

Heliyon

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Background Sparse population-based data are available on the prevalence and etiology of chronic liver disease (CLD) in Italy. The study aims to assess the role of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection in CLD according to age, gender and ethnicity. Methods Clinically diagnosed CLD in the general population aged 20–59 years in the Veneto Region (North-Eastern Italy) were identified through the Adjusted Clinical Groups System, by record linkage of the archive of subjects enrolled in the Regional Health System with Hospital Discharge Records, Emergency Room visits, Chronic disease registry for copayment exemptions, and the Home care database. Age-standardized prevalence rates (PR) were computed in Italians and immigrants, based on country of citizenship. Results Overall 22,934 subjects affected by CLD in 2016 were retrieved, 21% related to HBV and 43% to HCV infection. The prevalence of HCV-related CLD was higher in males, peaking at 50–54 years (males = 11/1000; females = 4/1000). The PR of HBV-related CLD was almost negligible in the Italian population (1/1000), and higher among immigrants, especially from East Asia (males = 17/1000; females = 11/1000) and Sub-Saharan Africa (males = 13/1000; females = 10/1000). Conclusion Specific population sub-groups identified by age, gender, and ethnicity, were demonstrated to be at increased risk, and these trends are in line with global epidemiological patterns of viral hepatitis.

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Section: Discussionmentioning

confidence: 68%

Section: Introductionmentioning

confidence: 99%

Prevalence of chronic liver disease among young/middle-aged adults in Northern Italy: role of hepatitis B and hepatitis C virus infection by age, sex, ethnicity

Fedeli

Avossa

Ferroni

et al. 2019

Heliyon

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“…15,16 The second wave affected mainly young adults in the 1980s, due to the diffusion of intravenous drug use. This wave is reflected by APC analyses and has been fueling an increase in HCV-related mortality among middle-aged males, 6 which fortunately seems to be levelling-off in more recent years (Figure S1). The impact of the COVID-19 pandemic on these trends was limited, as regression models indicate peaks in CLD-related deaths coinciding with COVID-19 epidemic waves, but overall CLD-related mortality rates continued to decline in 2020 and 2021.…”

Section: Re Sultsmentioning

confidence: 99%

“…5 Based on MCOD data, it has been observed that HCV-related mortality has increased over the past few decades within certain birth cohorts in countries such as the US and Italy. 5,6 In the US, recent changes in trends have been reported, where HCVrelated mortality has been seen to decline after the introduction of direct-acting antiviral (DAA) treatment. 7 Furthermore, analyses conducted on MCOD records in the US have revealed distinct effects of the Coronavirus Disease 2019 (COVID-19) pandemic on CLD-related mortality depending on its aetiology.…”

Section: Introductionmentioning

confidence: 99%

“…However, analyses including all the diseases mentioned on death certificates, known as the “multiple causes of death” (MCOD) approach, are better suited to capture changes in CLD‐related mortality associated with specific causes, such as hepatitis C virus (HCV) 5 . Based on MCOD data, it has been observed that HCV‐related mortality has increased over the past few decades within certain birth cohorts in countries such as the US and Italy 5,6 . In the US, recent changes in trends have been reported, where HCV‐related mortality has been seen to decline after the introduction of direct‐acting antiviral (DAA) treatment 7 .…”

Section: Introductionmentioning

confidence: 99%

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Mortality related to HCV and other chronic liver diseases in Veneto (Italy), 2008–2021: Changes in trends and age‐period‐cohort effects

Casotto,

Amidei,

Saia

et al. 2023

Liver International

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Background and AimsThe objective of this study was to assess the impact of the COVID‐19 pandemic and direct‐acting antiviral (DAA) agents on mortality related to chronic liver diseases (CLD).MethodsAge‐standardized mortality rates were computed based on CLD as the underlying cause of death (UCOD) and as any mention in death certificates (multiple causes of death‐MCOD). Time trends in age‐standardized mortality rates were investigated using generalized estimation equation models. Additionally, we conducted age, period, and birth cohort (APC) analyses on CLD‐related mortality associated with alcohol and hepatitis C virus (HCV).ResultsBetween 2008 and 2021, among residents in the Veneto region (Northeastern Italy) aged ≥35 years, there were 20 409 deaths based on the UCOD and 30 069 deaths based on MCOD from all CLD. We observed a 4% annual decline in age‐standardized MCOD‐based mortality throughout 2008–2021, with minor peaks corresponding to COVID‐19 epidemic waves. Starting in 2016, the decline in HCV‐related mortality accelerated further (p < .001). A peak in HCV‐related mortality in the 1963–1967 birth cohort was observed, which levelled off by the end of the study period. Mortality related to alcoholic liver disease declined at a slower pace, becoming the most common aetiology mentioned in death certificates.ConclusionsThe study demonstrates a significant decrease in HCV‐related mortality at the population level in Italy with the introduction of DAAs. Continuous monitoring of MCOD data is warranted to determine if this favourable trend will continue. Further studies utilizing additional health records are needed to clarify the role of other CLD etiologies.

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Mortality from chronic liver disease: Recent trends and impact of the COVID-19 pandemic

Fedeli¹,

Amidei²,

Casotto³

et al. 2023

World J Gastroenterol

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Coronavirus disease 2019 (COVID-19) has several extrapulmonary symptoms. Gastrointestinal (GI) symptoms are among the most frequent clinical manifestations of COVID-19, with severe consequences reported in elderly patients. Furthermore, the impact of COVID-19 on patients with pre-existing digestive diseases still needs to be fully elucidated, particularly in the older population. This review aimed to investigate the impact of COVID-19 on the GI tract, liver, and pancreas in individuals with and without previous digestive diseases, with a particular focus on the elderly, highlighting the distinctive characteristics observed in this population. Finally, the effectiveness and adverse events of the anti-COVID-19 vaccination in patients with digestive disorders and the peculiarities found in the elderly are discussed.

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Increasing mortality associated with the more recent epidemic wave of hepatitis C virus infection in Northern Italy

Cited by 3 publications

References 10 publications

Prevalence of chronic liver disease among young/middle-aged adults in Northern Italy: role of hepatitis B and hepatitis C virus infection by age, sex, ethnicity

Prevalence of chronic liver disease among young/middle-aged adults in Northern Italy: role of hepatitis B and hepatitis C virus infection by age, sex, ethnicity

Mortality related to HCV and other chronic liver diseases in Veneto (Italy), 2008–2021: Changes in trends and age‐period‐cohort effects

Mortality from chronic liver disease: Recent trends and impact of the COVID-19 pandemic

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