Increasing Levels of Macrophage Migration Inhibitory Factor in COVID-19 Infection and Its Pathophysiological Role; Cut-off Value Determination Might Be Clinically Misleading
Abstract:Background: The serious outbreak of coronavirus disease 2019 (COVID-19) has provoked deep concern throughout the world. The pathophysiologic network leading to severe conditions has still unsolved gaps. Considered a pleiotropic, multifaceted cytokine, macrophage migration inhibitory factor (MIF) has distinct functions, which seem to stand at the edge of distinct known mechanisms involving in COVID-19 pathogenesis. Additionally, MIF is a key mediator of acute respiratory distress syndrome and lung injury. Objec… Show more
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