Increasing intakes of iron reduce status, absorption and biliary excretion of copper in rats

Yu, Shiguang; West, C.E.; Beynen, A.C.

doi:10.1079/bjn19940194

Cited by 45 publications

(18 citation statements)

References 18 publications

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“…Interestingly, it has been reported that serum levels of copper and zinc in pregnant women taking iron supplements are lower than in pregnant women who do not take the supplement [23,24]. Perhaps, Iron affects the intestinal absorption of divalent metals and can reduce trace elements such as copper and zinc [25]. On the other hand, O'Brien et al [23] reported that administration of 60 mg of iron and 250 μg of folate without zinc supplementation during pregnancy caused a reduction of plasma zinc concentration; they therefore recommended the inclusion of zinc in prenatal supplements in order to reduce the potential of iron supplementation to adversely influence zinc status.…”

Section: Discussionmentioning

confidence: 96%

Anaemia, Zinc and Copper Deficiencies Among Pregnant Women in Central Sudan

Bushra

Elhassan

Ali³

et al. 2009

Biol Trace Elem Res

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Anaemia is a widespread problem in many parts of the world especially in tropic areas. Among pregnant women, it has negative consequences on maternal and perinatal outcomes. A cross-sectional study was conducted to investigate the prevalence of anaemia, iron, zinc and copper deficiencies among pregnant women in Wad Medani hospital, central Sudan and to examine the relationship of these micronutrients with haemoglobin (Hb) levels. One hundred four (52.5%) out of 200 pregnant women had anaemia (Hb < 11 gm/dl) and 3 (1.5) % had severe anaemia (Hb < 7 gm/dl). Iron deficiency (S-ferritin < 15 µg/l), iron deficiency anaemia (<11 gm/dl and S-ferritin < 15 µg/l) were prevalent in 25 (12.5%) and 13 (6.5%) of these women, respectively. Ninety (45.0%) and eight (4.0%) of these women had zinc (<80 µg/ml) and copper (<80 µg/ml) deficiency, respectively. In 24 (12.0%) of these women, there were ≥2 deficiencies of these elements. S-copper was not [corrected] significantly lower in patients with anaemia. While age, parity, gestational age, ferritin, zinc and copper were not predictors for anaemia, women who practiced pica were at higher risk for anaemia (OR = 3.4, 95% CI = 1.4-7.9, P = 0.004). Gestational age was significantly inversely correlated with haemoglobin (r = 0.161, P = 0.03), S-ferritin (r = 0.285, P = 0.001) and S-zinc (r = 0.166, P = 0.02). Thus, dietary and supplement interventions are required to prevent and control anaemia in this setting. Further research is needed.

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Section: Discussionmentioning

confidence: 96%

Anaemia, Zinc and Copper Deficiencies Among Pregnant Women in Central Sudan

Bushra

Elhassan

Ali³

et al. 2009

Biol Trace Elem Res

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“…In humans, addition of a 5-fold excess of Mn 2+ inhibited by 34% the absorption of iron present in a meal, while Zn 2+ did not inhibit iron absorption under these conditions [17]. Male rats fed diets containing increasing amounts of FeSO 4 showed slightly decreased concentrations of copper in plasma, liver, spleen, kidney and bile [18]. These results suggest a possible inverse correlation between iron and copper absorption, but other effects of iron on copper metabolism may occur.…”

Section: Background and Aimsmentioning

confidence: 99%

Effect of Copper, Cadmium, Mercury, Manganese and Lead on Fe<sup>2+</sup> and Fe<sup>3+</sup> Absorption in Perfused Mouse Intestine

Iturri¹,

Núñez

1998

Digestion

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Body iron homeostasis is maintained by the regulation of iron absorption in the first portion of the small intestine. Previous studies have shown that some trace metal cations may have an inhibitory effect on inorganic iron absorption. In view of the possible nutritional and toxicological implications of this inhibition, we decided to study the effect of Cu²⁺, Cd²⁺, Hg²⁺, Pb²⁺, and Mn²⁺ on Fe²⁺ and Fe³⁺ intestinal uptake. To that end, the duodenal portion of the mouse intestine was perfused with 1 µM ⁵⁵Fe either in the 2+ or 3+ redox state, in the absence or presence of a 10-fold molar excess of Cd²⁺, Cu²⁺, Hg²⁺, Mn²⁺, or Pb²⁺. It was found that Cd²⁺ and Cu²⁺, but not Hg²⁺, Mn²⁺, or Pb²⁺, significantly inhibited the uptake of Fe²⁺ (p < 0.001). Surprisingly, the observed inhibition by Cu²⁺ and Cd²⁺ was dependent on the iron redox state, since neither cation inhibited Fe³⁺ uptake by mouse duodenum. Similarly, no inhibition of Fe³⁺ uptake was observed with a 10-fold molar excess of Hg²⁺, Mn²⁺, or Pb²⁺. These results indicate that inhibition of iron uptake by Cu²⁺ and Cd²⁺ takes place only in a reducing environment. Therefore, under the common oxidative conditions found in nutrients no inhibition of non-heme Fe uptake by Cu²⁺ and Cd²⁺, as well as Mn²⁺, Hg²⁺ and Pb²⁺ is to be expected. We propose either that Fe²⁺ and Fe³⁺ are transported through two different mechanisms, or that the enterocyte-mediated reduction of Fe³⁺, and the ensuing transport of Fe²⁺ are processes coupled in such a way that they are refractory to inhibition by Cu²⁺ and Cd²⁺.

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“…These data support a major role of copper status in the modulation of iron uptake in intestinal cells [84]. The reduced copper absorption in rats, due to the introduction of Fe(II) in the diet, leads to hypothesize a competition between iron and copper for the same transporter [85]. The molecular bases for these data have been recently clarified by the demonstration that copper could compete with iron for uptake via DMT1 [86].…”

Section: Copper Pumpsmentioning

confidence: 83%