Increasing incidence of multiple sclerosis among women in Lorraine, Eastern France

Debouverie, Marc; Pittion‐Vouyovitch, S.; Louis, Sarah; Roederer, Thomas; Guillemin, Françis

doi:10.1177/1352458507077938

Cited by 75 publications

(70 citation statements)

References 21 publications

(31 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The sample comprised of 202(31.9%) male, and 431(68.1%) females. (20)(21)(22)(23)(24), While (34.1%) of the respondents Aged between (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35), While (18.8%) of the respondents Aged more than 35. Table (3) that (34.4%) of the respondents belong to the eastern region, while (33.5%) of them belong to the western region, (20.4%) of them belong to the Central Region, and (7.3%) of them belong to the southern district.…”

Section: Methodology:-mentioning

confidence: 96%

Prevalence of Multiple Sclerosis in Saudi Arabia

Alshanqiti¹,

Alotaibi²,

Alahmed³

et al. 2016

IJAR

View full text Add to dashboard Cite

This study aimed at detecting a rough estimation of the prevalence of multiple sclerosis among citizens of Saudi Arabia. Methodology:It is a cross sectional study purposed to estimate the prevalence of multiple sclerosis in KSA in 2016. It involved 633 individual from the society of Saudi Arabia. Results and conclusion:Most of the respondents (68.1%)were female, Also most of them (47.1%) aged between (20-24) , (94.5%) of them were Saudi national, the largest proportion of them (34.4%) live in the eastern region, (69.8%) of them hold a university degree, and (57.7%) of the respondents are single. Also, we found out that (66.2%) of the respondents don't know if they have MS or not, while (64.1%) of them don't have relatives suffer from MS, as (24.3%) of the relatives who suffer from MS were cousins, and the most common suspicious symptom of MS was Fatigue Exhaustion as (6.8%) of the respondents have that symptom, also (96.4%) of the respondents don't suffer from immune diseases, and most of those who suffer from immune diseases (26.1%) suffer from eczema. Also, (86.1%) of the respondents don't suffer from Genetics diseases, while(18.2%) of the respondents who suffer from Genetic disease suffer from diabetes, and (71.7) of the respondents who suffer MS are females, while 49.1%) of the respondents who suffer MS aged between 25-35, (84.9%) of the respondents who suffer MS are Saudi national, and (39.6%) of the respondents who suffer MS live in the Objectives:-Central region, as (73.6%) of the respondents who suffer MS hold a university degree. The analysis illustrated that (64.2%) of the respondents who suffer from MS don't have relatives suffer from MS, and (33. ISSN: 2320-5407Int. J. Adv. Res. 4(12), 1581-1600 1582 (83.0%) of the respondents who suffer from MS don't suffer from immune diseases, and (22.2 %) of the respondents who suffer from MS and immune diseases suffer from rhumatic fever or erthymatosis, as (96.2%) of the respondents who suffer from MS don't suffer from Genetic disease, and (50%) of the respondents who suffer from MS and Genetics disease suffer from diabetes or hypertension. The results of analysis illustrated that there were statistically significant differences between those with and without MS as regard to age, nationality and the region (P<0.05), while there were no statistically significant differences as regard to gender, education and marital status(P>0.05). Also, MS was more prevalent between 25 and 30 years (49.1%), in Saudi nation (84.9%) and the central region (39.6%). Also, there were statistically significant differences at the level of significance (P <0.05), in the prevalence of MS in the relatives of the patients with and without MS in favor of no prevalence of MS in the relatives of (64.1%) patients with and without of respondents, We found that there were statistically significant differences between those with and without MS as regard to absence of suspicious symptoms of MS of Weakness in arm or leg, Loss of Balance and Anxiety (P<0.05), while there were no statistically sign...

show abstract

Section: Methodology:-mentioning

confidence: 96%

Prevalence of Multiple Sclerosis in Saudi Arabia

Alshanqiti¹,

Alotaibi²,

Alahmed³

et al. 2016

IJAR

View full text Add to dashboard Cite

show abstract

“…autoimmunity | cytokines | experimental autoimmune encephalomyelitis | gender | nuclear receptor F or reasons that remain unclear, the incidence of multiple sclerosis (MS) is increasing in women (1) and, overall, women are three times more likely to be diagnosed with MS than men (1,2). The same is true for a number of other autoimmune diseases (3).…”

mentioning

confidence: 99%

Peroxisome proliferator-activated receptor (PPAR)α and -γ regulate IFNγ and IL-17A production by human T cells in a sex-specific way

Zhang

Rego

Moshkova

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

192

177

View full text Add to dashboard Cite

Women develop certain autoimmune diseases more often than men. It has been hypothesized that this may relate to the development of more robust T-helper (Th)1 responses in women. To test whether women exhibit a Th1 bias, we isolated naïve cluster of differentiation (CD)4 + T cells from peripheral blood of healthy women and men and measured the proliferation and cytokine production by these cells in response to submaximal amounts of anti-CD3 and anti-CD28. We observed that CD4 + T cells from women produced higher levels of IFNγ as well as tended to proliferate more than male CD4 + T cells. Intriguingly, male CD4 + T cells instead had a predilection toward IL-17A production. This sex dichotomy in Th cytokine production was found to be even more striking in the Swiss/Jackson Laboratory (SJL) mouse. Studies in mice and humans indicated that the sexual dimorphism in Th1 and Th17 cytokine production was dependent on the androgen status and the T-cell expression of peroxisome proliferator activated receptor (PPAR)α and PPARγ. Androgens increased PPARα and decreased PPARγ expression by human CD4 + T cells. PPARα siRNA-mediated knockdown had the effect of increasing IFNγ by male CD4 + T cells, while transfection of CD4 + T cells with PPARγ siRNAs increased IL-17A production uniquely by female T cells. Together, our observations indicate that human T cells exhibit a sex difference in the production of IFNγ and IL-17A that may be driven by expressions of PPARα and PPARγ. autoimmunity | cytokines | experimental autoimmune encephalomyelitis | gender | nuclear receptor

show abstract

“…It has long been known that women are more likely to have MS than men, and recent reports have found a widening sex gap in diagnosis. [1][2][3] Although sex has a less dramatic effect on disease progression and clinical outcomes, several studies have reported more severe symptoms and faster progression in men. [4][5][6][7] The underlying processes thought to be involved in the development and progression of MS demonstrate significant sex differences.…”

mentioning

confidence: 99%