Increasing incidence of hip fracture in Tottori Prefecture, Japan: Trend from 1986 to 2001

Hagino, Hiroshi; Katagiri, Hiroshi; Okano, T.; Yamamoto, Kichizo; Teshima, Ryota

doi:10.1007/s00198-005-1974-5

Cited by 97 publications

(70 citation statements)

References 36 publications

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“…(12) To compare the overall rates of hip fractures in women and men in Beijing to the rates in other countries we also standardized the rates for other selected countries to the 2004 US Census where reports provided sufficient data. (9,10,(12)(13)(14)(15)(16)(17)(18)(19) Results (Fig. 2).…”

Section: Analysesmentioning

confidence: 99%

Rapidly increasing rates of hip fracture in Beijing, China

Xia

et al. 2011

Journal of Bone and Mineral Research

172

112

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The age-specific rates of hip fractures have been declining in most countries in the West but a few studies suggest that the rates might be increasing in areas of Asia that are undergoing urbanization. We previously conducted a population-based study of hip fracture rates in Beijing, China, in 1990 to 1992 that included validation of hip fracture cases. Using a similar approach to validate cases, we estimated the age-specific hip fracture rates in Beijing, China, for 2002 to 2006. Specifically, we obtained hospital discharge data for hip fractures that were reported to the Beijing Bureau of Public Health. To confirm the diagnoses, Beijing residence, and find cases missed by the public records we checked individual cases in the public health records against medical records in a random sample of Beijing hospitals. The rates from public health data were adjusted for these under-and overestimations. We found that between 1990 and 1992 and 2002 and 2006, the adjusted age-specific rates of hip fracture over age 50 years increased 2.76-fold (95% confidence interval [CI], 2.68-2.84) in women and 1.61-fold (95% CI, 1.56-1.66) in men. Over age 70 years, the age-specific rates increased 3.37-fold (95% CI, 3.28-3.47) in women and 2.01-fold (95% CI, 1.95-2.07) in men. From 2002 to 2006, the rates over age 50 years increased 58% in women and 49% in men. We conclude that the rate of hip fracture has been rising very rapidly in Beijing, China. Therefore, the burden of hip fractures may be shifting rapidly from the West to urbanizing areas of the East. ß

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Section: Analysesmentioning

confidence: 99%

Rapidly increasing rates of hip fracture in Beijing, China

Xia

et al. 2011

Journal of Bone and Mineral Research

172

112

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“…(1,2) The number of osteoporotic fractures in Japan has been increasing as its society ages. (3,4) Osteoporotic fractures are associated with increased morbidity and mortality, and impose a huge financial burden on healthcare systems. (5)(6)(7) Preventing osteoporotic fractures in the elderly therefore represents an important issue in health economics.…”

Section: Introductionmentioning

confidence: 99%

“…Although the prevalence and incidence of vertebral fracture in Japan are higher than those in the United States and Europe, (15,16) the incidence rate of hip fracture, which may cause a greater burden than other osteoporotic fractures, is lower in Japan compared to Western countries. (3,17) Here we estimated the cost-effectiveness of alendronate therapy to prevent fractures in postmenopausal Japanese women who have low bone mineral density (BMD) but do not have osteoporosis or a history of fracture. Because the FRAX algorithm is not open to the public, we performed a model-based, costeffectiveness analysis that considered age, BMD, and the presence of clinical risk factors by using published sources.…”

Section: Introductionmentioning

confidence: 99%

Cost-effectiveness of alendronate for the treatment of osteopenic postmenopausal women in Japan

Moriwaki

Komaba

Noto

et al. 2012

Journal of Bone and Mineral Research

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Many postmenopausal women have osteopenia, a condition characterized by loss of bone mineral density (BMD) that is not as severe as in osteoporosis. The objective of this study was to estimate the cost-effectiveness of alendronate to prevent fractures in osteopenic postmenopausal women without a history of fracture in Japan. An individual simulation model was developed to predict lifetime costs and quality-adjusted life years (QALYs) of 5 years of preventive alendronate therapy versus no preventive therapy. The risk of hip and vertebral fracture associated with age and BMD was derived from epidemiologic studies in Japan. We ran the model with different combinations of age (65, 70, and 75 years), BMD (70%, 75%, and 80% of young adult mean [YAM]), and additional clinical risk factors. For 70-year-old women with a BMD of 70% of the YAM having one of the following risk factors: a family history of hip fracture, high alcohol intake, or current smoking, the incremental cost-effectiveness ratio (ICER) of alendronate was $92,937, $126,251, and $129,067 per QALY, respectively. These results were sensitive to age, BMD, and number of clinical risk factors. Probabilistic sensitivity analysis for the base case showed that in the presence of one, two, and three risk factors, alendronate was cost-effective in 0.2% to 2.6%, 13.1% to 56.1%, and 99.1% of the simulations, respectively, if society is willing to pay $50,000 per QALY. Additional analysis indicated that alendronate can be a good value in osteopenic women if the 10-year probability for a osteoporotic hip or vertebral fracture is more than 26.2%. Our results indicate that whether to treat osteopenia with alendronate should be determined on the basis of age, BMD, and number of clinical risk factors in terms of cost-effectiveness. ß

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“…Hagino et al reported that the incidence of hip fracture has been increasing in elderly women in Japan 2) . The prevention of hip fractures is important for maintaining independence of activities of daily living (ADL) and quality of life for elderly Japanese women, and the appropriate assessment of bone strength and physical function is necessary for the prevention of hip fracture.…”

Section: Introductionmentioning

confidence: 99%

The Timed Up and Go Test is Related to Quantitative Ultrasound Parameters of Bone Strength in Japanese Community-Dwelling Elderly Women

Kamide

Shiba

et al. 2009

J Phys Ther Sci

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Abstract.[Purpose] The timed up and go test (TUGT) requires no special equipment or training, and it is a simple clinical assessment tool. The aim of this study was to investigate the relationship between a quantitative ultrasound (QUS) parameter of bone strength and TUGT in Japanese community-dwelling elderly women.[Methods] Ninety-nine community-dwelling elderly women participated (mean age, 74.4 ± 5.7 years) in the present study. The speed of sound (SOS) in the right calcaneus was measured using a QUS device to assess bone strength. Physical function examinations included grip strength, single leg stance time, TUGT, and gait speed. The Tokyo Metropolitan Institute of Gerontology Index of Competence (TMIG-IC) was used to assess each subject's functioning, and each subject's age, height, and weight were also collected. [Results] In multiple linear regression analysis controlling for age, of the physical function parameters, only TUGT was significantly related to SOS in all subjects. Furthermore, the relationship between SOS and TUGT was significant for those with high TMIG-IC scores, but SOS was not associated with any physical function parameters (including TUGT) for those with low TMIG-IC scores.[Conclusion] TUGT may contribute to the development of a simple clinical assessment tool that could be used to screen for hip fracture risk.

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Increasing incidence of hip fracture in Tottori Prefecture, Japan: Trend from 1986 to 2001

Cited by 97 publications

References 36 publications

Rapidly increasing rates of hip fracture in Beijing, China

Rapidly increasing rates of hip fracture in Beijing, China

Cost-effectiveness of alendronate for the treatment of osteopenic postmenopausal women in Japan

The Timed Up and Go Test is Related to Quantitative Ultrasound Parameters of Bone Strength in Japanese Community-Dwelling Elderly Women

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