Increasing Incidence in Relapsing-Remitting MS and High Rates among Young Women in Finland: A Thirty-Year Follow-Up

Sumelahti, Marja‐Liisa; Holmberg, Markus; Murtonen, Annukka; Huhtala, Heini; Elovaara, Irina

doi:10.1155/2014/186950

Cited by 15 publications

(15 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…7,8 Incidence trends from 1981 to 2010 in the Province of Western Finland in Tampere University Hospital District showed a significant increase among women and opposite trends in increasing relapsing-remitting onset MS (RRMS) and decreasing primary progressive (PPMS). 9 These trends differed from a tandem increase in RRMS and PPMS reported in a Finnish MS cohort from 1979 to 1993. 10 We aim to study prevalence in 2000 and 2010 in the Province of Western Finland in Tampere University Hospital District and evaluate the impact of the observed incidence trends.…”

Section: Introductionmentioning

confidence: 75%

“…These demographic changes in disease course groups reflect the longevity effect. However, the impact of concurrent incidence changes from 1981 to 2010 in the same catchment area is to be considered, as we have reported a statistically significant increase in RRMS from 4.2 (95% CI 3.7-4.6) to 9.10.5)/10 5 and a drop in PPMS from 1.2 (0.9-1.4) to 0.7 (0.5-0.7), which differences however stabilized during the last study decade 9. These trends differed from the observation in a Finnish cohort diagnosed in 1979-1993, where a tandem increase in RRMS and PPMS was shown 10.…”

mentioning

confidence: 86%

“…Epidemiological data updated in 2016 showed a high nationwide MS crude prevalence estimate of 180‐200/10 5 and east‐west gradient . Incidence trends from 1981 to 2010 in the Province of Western Finland in Tampere University Hospital District showed a significant increase among women and opposite trends in increasing relapsing‐remitting onset MS (RRMS) and decreasing primary progressive (PPMS) . These trends differed from a tandem increase in RRMS and PPMS reported in a Finnish MS cohort from 1979 to 1993 …”

Section: Introductionmentioning

confidence: 92%

See 2 more Smart Citations

Multiple sclerosis prevalence in 2000 and 2010 in Western Finland

Murtonen

Sumelahti

2020

Acta Neurol Scand

Self Cite

View full text Add to dashboard Cite

Objective To study ten‐year change in MS prevalence in the Province of Western Finland in Tampere University Hospital District located in 62.7°N, 23.7°E. Methods Age‐standardized prevalence/105 by using direct standardization in European Standard Population (ESP2013) and crude prevalence/105 with 95% confidence interval (95% CI) were assessed among resident MS cases fulfilling Poser criteria by sex and disease course in 31.12.2000 and 31.12.2010. MS‐related disability and disease‐modifying treatment (DMT) use were estimated in 31.12.2010. Results Crude prevalence increased 49% from 129/105 (95% CI 121‐137) in 2000 (N 1080) to 196/105 (187‐203) in 2010 (N 1666). Age‐standardized prevalence increased 45% from 133/105 (127‐140) to 192/105 (184‐200) and peaked in 40‐ to 49‐year age‐group. Age‐standardized prevalence increased 58% among women from 176/105 (171‐176) to 277/105 (270‐284) and 31% among men from 91/105 (87‐95) to 119/105 (115‐124). Increase in RRMS was 61% from 111/105 (105‐117) to 179/105 (171‐186), and decrease in PPMS was 14% from 21/105 (19‐24) to 18/105 (15‐21). In 2010 among the 52% RRMS cases on DMT, MS‐related disability was mild in 50%. In total, cohort disability was mild in 46%, moderate to severe in 47%, and information was not available in 14%. Conclusion A significant increase in prevalence was observed in Western Finland. Increase was higher among women and in relapsing‐remitting onset MS. Disability showed age‐ and disease course‐specific variation.

show abstract

Section: Introductionmentioning

confidence: 75%

mentioning

confidence: 86%

Section: Introductionmentioning

confidence: 92%

See 1 more Smart Citation

Multiple sclerosis prevalence in 2000 and 2010 in Western Finland

Murtonen

Sumelahti

2020

Acta Neurol Scand

Self Cite

View full text Add to dashboard Cite

show abstract

“…It has however become clear during this analysis that there are more patients with relapsing remitting disease in the clinical data set than has been seen in other studies (Clinical 85.3%, Portal 67.2%). Previous MS registry studies (18), (19) the LORSEP Registry (17) and the Atlas of MS (20) have also indicated an RRMS population of more than 80% in newly diagnosed patients. This is clearly in agreement with the large proportion of RRMS diagnosed patients coming to the UK MS Register from our clinical sites.…”

Section: Discussionmentioning

confidence: 97%

Validating the portal population of the United Kingdom Multiple Sclerosis Register

Middleton

Rodgers

Chataway

et al. 2018

Multiple Sclerosis and Related Disorders

View full text Add to dashboard Cite

The UK Multiple Sclerosis Register (UKMSR) is a large cohort study designed to capture 'real world' information about living with multiple sclerosis (MS) in the UK from diverse sources. The primary source of data is directly from people with Multiple Sclerosis (pwMS) captured by longitudinal questionnaires via an internet portal. This population's diagnosis of MS is self-reported and therefore unverified. The second data source is clinical data which is captured from MS Specialist Treatment centres across the UK. This includes a clinically confirmed diagnosis of MS (by Macdonald criteria) for consented patients. A proportion of the internet population have also been consented at their hospital making comparisons possible. This dataset is called the 'linked dataset'. The purpose of this paper is to examine the characteristics of the three datasets: the self-reported portal data, clinical data and linked data, in order to assess the validity of the self-reported portal data. The internet (n = 11,021) and clinical (n = 3,003) populations were studied for key shared characteristics. We found them to be closely matched for mean age at diagnosis (clinical = 37.39, portal = 39.28) and gender ratio (female %, portal = 73.1, clinical = 75.2). The Two Sample Kolmogorov-Smirnov test was for the continuous variables to examine is they were drawn from the same distribution. The null hypothesis was rejected only for age at diagnosis (D = 0.078, p < 0.01). The populations therefore, were drawn from different distributions, as there are more patients with relapsing disease in the clinical cohort. In all other analyses performed, the populations were shown to be drawn from the same distribution. Our analysis has shown that the UKMSR portal population is highly analogous to the entirely clinical (validated) population. This supports the validity of the self-reported diagnosis and therefore that the portal population can be utilised as a viable and valid cohort of people with Multiple Sclerosis for study.

show abstract

“…In 2010, the incidence of MS in the western regions of Finland was 6.7‐12.5/100 000 person‐years and had increased over 30 years (1981‐2010), especially in the region of Ostrobothnia, which had a high incidence at the outset . During these three decades, the incidence had risen especially among females and the female‐to‐male ratio had increased …”

Section: Introductionmentioning

confidence: 99%

Multiple sclerosis epidemiology in Finland: Regional differences and high incidence

2019

View full text Add to dashboard Cite

Objectives Studies on the east‐west gradient of multiple sclerosis (MS) are scarce. In Finland, epidemiological differences have been only partially elucidated, but the MS risk is high, and it has been claimed that the occurrence follows a longitudinal gradient. In this register‐based study, we updated the MS epidemiology in southwest Finland (SwF) and compared it to the easternmost hospital district, North Karelia (NK), for which no previous data exist. Materials and methods Patients with ICD‐10 code G35 were identified from hospital district administrative data. Patient records were reviewed to include only cases with a definitive diagnosis. Incidence period covered 5 years (2012‐2016), and the prevalence date was December 31, 2016. Results were standardized using the direct method. Results A total of 1184 persons had MS in SwF and 253 persons in NK at the end of 2016. The prevalence was 280/100 000 (95% CI 264‐296) in SwF and 168/100 000 (95% CI 148‐190) in NK (age‐standardized for the European standard population 2013). During the incidence period, 211 new MS diagnoses were made in SwF and 49 in NK. The annual age‐standardized (ESP 2013) incidence was 12.1/100 000 person‐years (95% CI 10.5‐13.8) in SwF and 8.6/100 000 person‐years (95% CI 6.4‐11.2) in NK in the age‐group 10‐69 years. Conclusions There are regional differences in MS epidemiology in Finland, possibly related to demographic, social, and genetic circumstances, but the retrospective nature and limited sample size of this study might introduce some uncertainty to the calculations. SwF is a region with a globally very high risk for MS.

show abstract

Increasing Incidence in Relapsing-Remitting MS and High Rates among Young Women in Finland: A Thirty-Year Follow-Up

Cited by 15 publications

References 42 publications

Multiple sclerosis prevalence in 2000 and 2010 in Western Finland

Multiple sclerosis prevalence in 2000 and 2010 in Western Finland

Validating the portal population of the United Kingdom Multiple Sclerosis Register

Multiple sclerosis epidemiology in Finland: Regional differences and high incidence

Contact Info

Product

Resources

About