Increasing incidence and survival in oral cancer: a nationwide Danish study from 1980 to 2014

Background Recent declines in cancer incidence and mortality have not been distributed equally across the United States. Factors such as tobacco cessation and human papillomavirus presence might differentially affect urban and rural portions of the country. Methods We used the Surveillance, Epidemiology, and End Results database to assess cancer incidence rates and trends from 1973 to 2015. We compared incidence rates for oral cavity, oropharynx, and larynx cancer in urban and rural counties and identified trends using Joinpoint software. Results Incidence of larynx and oral cavity cancer are decreasing faster in urban areas than in rural areas, while incidence of oropharynx cancer is increasing faster in rural areas than urban areas. Conclusions Relative trends in incidence of larynx, oral cavity, and oropharynx cancer over the past 40 years are unfavorable for rural United States counties compared with urban areas. Cancer control programs should take this into account.

show abstract

“…The cause for this increase is not entirely clear. A similar trend was reported by Karnov et al in a study of the Danish population …”

Section: Discussionsupporting

confidence: 91%

Incidence trends for upper aerodigestive tract cancers in rural United States counties

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The five-year DSS for the whole cohort was about 52%, and this is in accordance with Warnakulasuriya et al [7]. The five-year OS in our Norwegian cohort was about 47%, which is somewhat higher than reported in a Danish cohort for the same period (44%) [15], but lower than in a Finnish study (61%). However, the Finnish study included only patients with oral squamous cell carcinoma of the tongue treated in curative intent [10].…”

Section: Discussionsupporting

confidence: 91%

“…This is somewhat older than reported in our neighboring countries Finland and Denmark (65.6 and 63 years, respectively) [10,15] The men in our population were eight years younger at time of diagnosis compared to the women. Similar gender differences in age at diagnosis have also been reported in other cohorts described from Denmark, the United States and in Northern Norway [15,16,33]. The younger age at diagnosis for men may be due to more cigarette smoking and a higher consumption of alcohol than for women [35].…”

Section: Discussioncontrasting

confidence: 59%

“…Globally, men have higher risk of oral cancer than women and we found a male/female ratio of 1.2. This ratio is slightly lower than reported from a Danish and a US study (1.5 and 1.8 respectively) [15,16], and slightly higher than reported in a Finnish study with 0.9 [10]. This relatively small gender difference in oral cancer incidence may reflect that the tobacco and alcohol consumption has become more similar for men and women over the last three decades.…”

Section: Discussioncontrasting

confidence: 51%

See 1 more Smart Citation

Characteristics of and Survival in Oral Squamous Cell Carcinomas in Norway (NOROC) 2005-2009

Bjerkli

Jetlund

Karevold

et al. 2019

Preprint

View full text Add to dashboard Cite

Background: Incidence of oral squamous cell carcinomas (OSCC) is rising worldwide, and population characterization is important to follow future trends. Methods: Patients treated for primary OSCC at all four University Hospitals in Norway between 2005 and 2010 were retrospectively included in this study. The median follow up time was 48 months (range 0-125 months). Results: 535 patients with primary OSCC were identified. The overall survival (OS) was found to be 47%, disease specific survival (DSS) was 52%. When extracting the patients given treatment in curative intent the OS was found to be 56.2% and DSS 62.3%. Median age at diagnosis was 67 years (range 24-101 years), and men were in general eight years younger than women. The male/female ratio was 1.2. No gender difference was found in T status or N status, but both factors influenced significantly on survival. Conclusions: We present a large and validated cohort of primary OSCC. Patients with small tumors and stage I-II at time of diagnosis had better outcome, and habitual examination of the oral cavity by patients, dentists and physicians may shift more tumors to a more beneficial starting point.

show abstract

“…Collectively, these head and neck cancers constitute the seventh most common malignancy in terms of incidence and the ninth most common cause of death in the world (Purkayastha, McMahon, Gibson, & Conway, ). Despite recent clinical improvements in diagnosis and treatment, the 5 year survival rate of patients with OSCC has been reported to have remained low at approximately 50% (Schmidt Karnov et al, ; Purkayastha et al, ).…”

Section: Introductionmentioning

confidence: 99%

Oral cancer‐associated fibroblasts predict poor survival: Systematic review and meta‐analysis

et al. 2019

View full text Add to dashboard Cite

Objectives To perform systematic review and meta‐analysis on correlations between cancer‐associated fibroblasts (CAFs) and the risk of death for patients with oral squamous cell carcinoma. Subjects and methods English literature (1966–2018) was systematically analyzed for studies that immunohistochemically assessed CAF density by alpha‐smooth muscle actin and presented 5 year survival rates by Kaplan–Meier plots. Mean age of patients, proportion of male/female patients, and male/female majority (>50% male/female patients) per study were also collected. Significance level for statistical models was p < 0.05. Results Meta‐analysis comprised 11 studies/1,040 patients. Univariate Cox regressions showed that high CAF density was a negative prognostic factor in studies with female and male majority [OR 5.329 (95% CI 3.223–8.811), p < 0.001, and OR 2.208 (95% CI 1.717–2.839), p < 0.001, respectively]. High CAF density with male majority was associated with a more favorable prognosis [OR 0.996 (95% CI 0.979–1.013), p < 0.001]. Multivariate Cox regressions showed that death risk was significantly higher among patients with high CAF density compared to low CAF [OR 2.741 (95% CI 2.220–3.384) p < 0.001]. High mean age and male proportion were significantly protective [OR 0.940 (95% CI 0.925–9.955), p < 0.001, OR 0.125 (95% CI 0.018–0.867), p = 0.035), respectively]. Conclusions CAFs increased death risk, male majority, and higher mean age were protective. A clinically validated cutoff for CAF density could serve as a reliable prognostic tool.

show abstract

Increasing incidence and survival in oral cancer: a nationwide Danish study from 1980 to 2014

Abstract: We found an unexpected increase in the age-standardized incidence of OC during the last 30 years in Denmark, and also an improvement in survival. The 5-year OS was significantly better in recent years even when we adjusted the analysis for relevant covariates.

Cited by 34 publications

References 22 publications

Incidence trends for upper aerodigestive tract cancers in rural United States counties

Incidence trends for upper aerodigestive tract cancers in rural United States counties

Characteristics of and Survival in Oral Squamous Cell Carcinomas in Norway (NOROC) 2005-2009

Oral cancer‐associated fibroblasts predict poor survival: Systematic review and meta‐analysis

Contact Info

Product

Resources

About