Increasing heat storage by wearing extra clothing during upper body exercise up-regulates heat shock protein 70 but does not modify the cytokine response

Leicht, Christof A.; Papanagopoulos, Aris; Haghighat, Sam; Faulkner, Simon

doi:10.1080/02640414.2016.1235795

Cited by 2 publications

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References 34 publications

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“…52 Should chronic PH enhance IL-6R expression as is evident following EX training, 53 interventions capable of increasing both IL-6 and IL-6R, may provide a therapeutic basis for improving glycemic control. Moreover, it has recently been shown that acute PH elevates the anti-inflammatory cytokines IL-1ra and IL-10, 54 suggesting that chronic PH may benefit the inflammatory profile in a similar way to EX. However, long-term investigation of PH is required to corroborate this hypothesis.…”

Section: Discussionmentioning

confidence: 99%

The effect of passive heating on heat shock protein 70 and interleukin-6: A possible treatment tool for metabolic diseases?

et al. 2017

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Increasing physical activity remains the most widely publicized way of improving health and wellbeing. However, in populations that benefit most from exercise (EX), adherence is often poor and alternatives to EX are important to bring about health improvements. Recent work suggests a role for passive heating (PH) and heat shock proteins (HSP) in improving cardio-metabolic health. The aim of this study was to investigate the expression of HSP70 and interleukin-6 in response to either EX or PH and the subsequent effect on glucose control. Fourteen males volunteered and were categorized lean (BMI 23.5 § 2.2 kg¢m ¡2 ) or overweight (29.2 § 2.7 kg¢m ¡2 ) and completed 60 minutes of either moderate cycling at a fixed rate of metabolic heat production (EX) or warm water immersion in 40 C water (PH). Extracellular HSP70 increased from baseline in both conditions with no differences between PH (0.98 § 1.1 ng¢mL ¡1 ) or EX (0.84 § 1.0 ng¢mL ¡1 , p D 0.814). IL-6 increased following both conditions with a two-fold increase after PH and four-fold after EX. Energy expenditure increased by 61.0 § 14.4 kcal¢h ¡1 (79%) after PH. Peak glucose concentration after a meal immediately following PH was reduced when compared with EX (6.3 § 1.4 mmol¢L ¡1 versus 6.8 § 1.2 mmol¢L ¡1 ; p < 0.05). There was no difference in 24-hour glucose area under the curve (AUC) between conditions. These data indicate the potential for thermal therapy as an alternative treatment and management strategy for those at risk of developing metabolic disease where adherence, or ability to EX, may be compromised.

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confidence: 99%

The effect of passive heating on heat shock protein 70 and interleukin-6: A possible treatment tool for metabolic diseases?

et al. 2017

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The inflammatory response to a wheelchair half-marathon in people with a spinal cord injury - the role of autonomic function

Hoekstra

Leicht

Kamijo

et al. 2019

Journal of Sports Sciences

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9 10 11 Running title: Autonomic function and the inflammatory response to a wheelchair half-12 marathon 13 The authors declare no conflicts of interest. 14 interleukin-6; heat shock protein 72; wheelchair racing; upper-body exercise; sympathetic 15 response; adrenaline 16 Word count: 4283 17 Abstract 32This study investigates the relationship between autonomic function and the inflammatory 33 response to a wheelchair half-marathon in people with a spinal cord injury (SCI). Seventeen 34 wheelchair athletes with a cervical SCI (CSCI, N=7) and without CSCI (NON-CSCI, N=10) 35 participated in a wheelchair half-marathon. Blood was taken prior, post and 1 h post-race to 36 determine the concentrations of adrenaline, noradrenaline, extracellular heat shock protein 72 37 (eHsp72) and interleukin-6 (IL-6). A sit-up tilt test was performed to assess autonomic 38 function at rest. CSCI showed a lower supine ratio of the low and high frequency power of 39 the variability in RR intervals (LF/HF RRI, p=0.038), total and low frequency power of the 40 systolic blood pressure variability (TP SBP, p<0.001; LF SBP, p=0.005) compared to NON-41 CSCI. Following the race, catecholamine concentrations increased only in NON-CSCI 42 (p<0.036). The increase in IL-6 post-race was larger in NON-CSCI (p=0.040). Post-race 43 catecholamine levels explained 60% of the variance in the IL-6 response (r=0.77, p=0.040), 44which was further increased when the resting autonomic function indices were added to the 45 regression model (R 2 >81%, p<0.012). In summary, the dampened acute inflammatory 46 response to a wheelchair half-marathon in CSCI was strongly associated with the autonomic 47 dysfunction present in this group.

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Increasing heat storage by wearing extra clothing during upper body exercise up-regulates heat shock protein 70 but does not modify the cytokine response

Cited by 2 publications

References 34 publications

The effect of passive heating on heat shock protein 70 and interleukin-6: A possible treatment tool for metabolic diseases?

The effect of passive heating on heat shock protein 70 and interleukin-6: A possible treatment tool for metabolic diseases?

The inflammatory response to a wheelchair half-marathon in people with a spinal cord injury - the role of autonomic function

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