Increasing deaths involving oxycodone, Victoria, Australia, 2000–09

Rintoul, Angela; Dobbin, Malcolm; Drummer, Olaf H.; Ozanne‐Smith, Joan

doi:10.1136/ip.2010.029611

Cited by 91 publications

(86 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…4 Similar phenomena have been observed in Canada, 5 the United Kingdom, 6 and Australia. 7 Although a great deal of harm associated with prescription opioids involves patients, misuse and overdose can also occur as the result of diversion, medication sharing, and other indirect mechanisms. However, the impact of prescription opioids on young children in the home has not been well studied.…”

Section: What This Study Addsmentioning

confidence: 99%

Overdose Risk in Young Children of Women Prescribed Opioids

et al. 2017

View full text Add to dashboard Cite

show abstract

Section: What This Study Addsmentioning

confidence: 99%

Overdose Risk in Young Children of Women Prescribed Opioids

et al. 2017

View full text Add to dashboard Cite

show abstract

“…[1][2][3][4][5] This has been accompanied by a marked increase in opioid-related morbidity and mortality. 3,[6][7][8] In Ontario, the rate of opioidrelated mortality has more than tripled since the early 1990s.…”

Section: Résumémentioning

confidence: 99%

“…3 The same phenomenon-a rise in opioid prescriptions with a corresponding increase in mortality-has been reported in both the United Kingdom (UK) and Australia. 4,5 While primary care physicians issue most opioid prescriptions, anesthesiologists utilize opioids regularly for anesthesia, acute postoperative pain, and the treatment of chronic pain. Herein, we detail the historical context surrounding the growth of this epidemic and create a framework for future discussion and research in the hope that anesthesiologists can make an important contribution to alleviate this problem.…”

Section: Résumémentioning

confidence: 99%

The prescription opioid epidemic: an overview for anesthesiologists

Alam

Juurlink

2015

Can J Anesth/J Can Anesth

View full text Add to dashboard Cite

Purpose The objectives for preparing this article were to review the historical context and epidemiology surrounding the North American prescription opioid crisis, to summarize the evidence regarding the benefits and harms of long-term opioid therapy for non-cancer pain, and to outline ways in which anesthesiologists may help ameliorate the problem. Source We searched PubMed, Google Scholar, and EMBASE TM for relevant articles using various search terms, including pain, opioid epidemic, history of opioid use, perioperative care, and addiction. Related citations were further explored and searched depending on the specific subtopic of interest. Principal findings In the 1980s and early 1990s, opioids were infrequently used for the treatment of chronic pain. Thereafter, however, physicians were gradually inculcated with the message that long-term opioid therapy was a safe and effective treatment option for patients with chronic non-cancer pain. Pharmaceutical companies supported this growing movement and employed aggressive and sometimes misleading marketing strategies for new opioid formulations. As a result, the practice of prescribing opioids flourished in the late 1990s. The surge in prescribing opioids was accompanied by a marked increase in opioid-related morbidity and mortality. This change in practice transpired despite the absence of randomized trials showing clinically significant benefit from the long-term use of opioids. Subsequently, however, a large and growing body of evidence has emerged quantifying the harms associated with long-term opioid therapy. Anesthesiologists widely prescribe opioids for acute and chronic pain; yet, as a group, they may be largely unaware of the current state of this growing epidemic and what role they can play to rectify this problem.Conclusion Anesthesiologists are well positioned to take a leadership role in the management of postoperative discharge opioid therapy in an effort to curb the overutilization of opioids. Furthermore, anesthesiologists who regularly prescribe opioids for chronic pain patients should appreciate the limited evidence base for this practice and communicate the risks of opioid therapy to their patients.

show abstract

“…1 Over the past 2 decades, rates of prescription opioid-related death have increased rapidly in the United States 2,3 and Australia. 4,5 In the US, there is extensive public health surveillance of prescription opioid-related harms using multiple systems that collect information on deaths, emergency department visits, calls to poison control centres and drug seizures from law enforcement agencies.…”

mentioning

confidence: 99%

Sensitivity and specificity of administrative mortality data for identifying prescription opioid–related deaths

Gladstone

Smolina

Morgan

et al. 2015

CMAJ

View full text Add to dashboard Cite

Background:Comprehensive systems for surveilling prescription opioid-related harms provide clear evidence that deaths from prescription opioids have increased dramatically in the United States. However, these harms are not systematically monitored in Canada. In light of a growing public health crisis, accessible, nationwide data sources to examine prescription opioid-related harms in Canada are needed. We sought to examine the performance of 5 algorithms to identify prescription opioid-related deaths from vital statistics data against data abstracted from the Office of the Chief Coroner of Ontario as a gold standard. Methods:We identified all prescription opioid-related deaths from Ontario coroners' data that occurred between Jan. 31, 2003, and Dec. 31, 2010. We then used 5 different algorithms to identify prescription opioid-related deaths from vital statistics death data in 2010. We selected the algorithm with the highest sensitivity and a positive predictive value of more than 80% as the optimal algorithm for identifying prescription opioid-related deaths. Interpretation:In the absence of specific systems for monitoring prescription opioid-related deaths in Canada, readily available national vital statistics data can be used to study prescription opioid-related mortality with considerable accuracy. Despite some limitations, these data may facilitate the implementation of national surveillance and monitoring strategies. Abstract Research E68CMAJ, March 1, 2016, 188(4)

show abstract

Increasing deaths involving oxycodone, Victoria, Australia, 2000–09

Cited by 91 publications

References 27 publications

Overdose Risk in Young Children of Women Prescribed Opioids

Overdose Risk in Young Children of Women Prescribed Opioids

The prescription opioid epidemic: an overview for anesthesiologists

Sensitivity and specificity of administrative mortality data for identifying prescription opioid–related deaths

Contact Info

Product

Resources

About