Increasing Deactivation of Limbic Structures Over Psychosocial Stress Exposure Time

Henze, Gina-Isabelle; Konzok, Julian; Kreuzpointner, Ludwig; Bärtl, Christoph; Peter, Hannah; Giglberger, Marina; Streit, Fabian; Kudielka, Brigitte M.; Kirsch, Peter; Wüst, Stefan

doi:10.1016/j.bpsc.2020.04.002

Cited by 11 publications

(41 citation statements)

References 49 publications

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“…Sixty-seven young, healthy, scanner-naïve university students (mean age 23.06 ± 3.14 years) participated in the present study. Stress-induced cortisol, affect, heart rate and neural responses of the present sample have been previously reported ( Henze et al. , 2020 ).…”

Section: Methodssupporting

confidence: 64%

“…, 2014 ). We found significant cortisol, subjective, heart rate and neural reactions in response to Scan STRESS ( Henze et al. , 2020 ).…”

Section: Introductionmentioning

confidence: 79%

“…The underlying mechanisms are still unknown but an influence of hunger and saturation regulating neuropeptides was discussed ( Rohleder and Kirschbaum, 2007 ). Third, we achieved a more abrupt passage (<10 min) from relaxation to stress exposure (details see Henze et al. (2020) ).…”

Section: Methodsmentioning

confidence: 99%

“…, 2019 ). A recent study by our group ( Henze et al. , 2020 ) aimed at elucidating the interaction of distinct stress activation systems in response to an improved psychosocial fMRI stress protocol ( Streit et al.…”

Section: Introductionmentioning

confidence: 99%

“…As an exploratory analysis, we also studied whether dynamic changes in neural stress responses, previously reported for (pre)limbic structures ( Henze et al. , 2020 ), differ between women and men.…”

Section: Introductionmentioning

confidence: 99%

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Sex-specific interaction between cortisol and striato-limbic responses to psychosocial stress

Henze

Konzok

Kreuzpointner

et al. 2021

Social Cognitive and Affective Neuroscience

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Although women and men differ in psychological and endocrine stress responses as well as prevalence rates of stress-related disorders, knowledge on sex differences regarding stress regulation in the brain is scarce. Therefore, we performed an in-depth analysis of data from 67 healthy participants (31 women, taking oral contraceptives), who were exposed to the ScanSTRESS paradigm in an fMRI study. Changes in cortisol, affect, heart rate, and neural activation in response to psychosocial stress were examined in women and men as well as potential sex-specific interactions between stress response domains. Stress exposure led to significant cortisol increases with men exhibiting higher levels than women. Dependent on sex, cortisol elevations were differently associated with stress-related responses in striato-limbic structures: Higher increases were associated with activations in men but with deactivations in women. Regarding affect or heart rate responses, no sex differences emerged. Although women and men differ in their overall stress reactivity, our findings do not support the idea of distinct neural networks as base of this difference. Instead, we found differential stress reactions for women and men in identical structures. We propose considering quantitative predictors like sex-specific cortisol increases when exploring neural response differences of women and men.

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Section: Methodssupporting

confidence: 64%

“…, 2014 ). We found significant cortisol, subjective, heart rate and neural reactions in response to Scan STRESS ( Henze et al. , 2020 ).…”

Section: Introductionmentioning

confidence: 79%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Sex-specific interaction between cortisol and striato-limbic responses to psychosocial stress

Henze

Konzok

Kreuzpointner

et al. 2021

Social Cognitive and Affective Neuroscience

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Neighborhood racial income inequality and cognitive health

Zahodne,

Sol,

Scambray

et al. 2024

Alzheimer's & Dementia

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INTRODUCTIONNeighborhood socioeconomic status (SES) has been linked to dementia, but the distribution of SES within a neighborhood may also matter.METHODSData from 460 (47% Black, 46% White) older adults from the Michigan Cognitive Aging Project were linked to census tract–level data from the National Neighborhood Data Archive (NaNDA). Neighborhood SES included two composites reflecting disadvantage and affluence. Neighborhood racial income inequality was the ratio of median incomes for White versus Black residents. Generalized estimating equations examined associations between neighborhood factors and cognitive domains.RESULTSNeighborhood racial income inequality was uniquely associated with worse cognitive health, and these associations did not differ by participant race. Neighborhood disadvantage was only associated with worse cognitive health among Black participants.DISCUSSIONBoth the level and racial distribution of SES within a neighborhood may be relevant for dementia risk. Racial differences in the level and impact of neighborhood SES contribute to dementia inequalities.Highlights Black participants lived in neighborhoods with lower socioeconomic status (SES) than White participants, on average. Neighborhood SES and racial income inequality were associated with worse cognition. Effects of neighborhood racial income inequality did not differ across racial groups. Effects of neighborhood SES were only evident among Black participants.

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Neural habituation during acute stress signals a blunted endocrine response and poor resilience

Liu,

Zhao,

et al. 2023

Psychol. Med.

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Background A blunted hypothalamic–pituitary–adrenal (HPA) axis response to acute stress is associated with psychiatric symptoms. Although the prefrontal cortex and limbic areas are important regulators of the HPA axis, whether the neural habituation of these regions during stress signals both blunted HPA axis responses and psychiatric symptoms remains unclear. In this study, neural habituation during acute stress and its associations with the stress cortisol response, resilience, and depression were evaluated. Methods Seventy-seven participants (17–22 years old, 37 women) were recruited for a ScanSTRESS brain imaging study, and the activation changes between the first and last stress blocks were used as the neural habituation index. Meanwhile, participants' salivary cortisol during test was collected. Individual-level resilience and depression were measured using questionnaires. Correlation and moderation analyses were conducted to investigate the association between neural habituation and endocrine data and mental symptoms. Validated analyses were conducted using a Montreal Image Stress Test dataset in another independent sample (48 participants; 17–22 years old, 24 women). Results Neural habituation of the prefrontal cortex and limbic area was negatively correlated with cortisol responses in both datasets. In the ScanSTRESS paradigm, neural habituation was both positively correlated with depression and negatively correlated with resilience. Moreover, resilience moderated the relationship between neural habituation in the ventromedial prefrontal cortex and cortisol response. Conclusions This study suggested that neural habituation of the prefrontal cortex and limbic area could reflect motivation dysregulation during repeated failures and negative feedback, which might further lead to maladaptive mental states.

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Increasing Deactivation of Limbic Structures Over Psychosocial Stress Exposure Time

Cited by 11 publications

References 49 publications

Sex-specific interaction between cortisol and striato-limbic responses to psychosocial stress

Sex-specific interaction between cortisol and striato-limbic responses to psychosocial stress

Neighborhood racial income inequality and cognitive health

Neural habituation during acute stress signals a blunted endocrine response and poor resilience

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