Increasing cancer incidence in a tertiary care hospital in a developing country, India

Cherian, Thomas; Mahadevan, Pushpa; Chandramathi, S; Govindan, Jayasree; Mathew, IL

doi:10.4103/0019-509x.175596

Cited by 12 publications

(11 citation statements)

References 6 publications

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“…17 A large regional variation in the age distribution is seen in India with cases less than 50 years representing 20-50% of the total cases. [18][19][20][21] Colorectal cancer in India thus appears to be more frequent in younger patients compared to the west, with large regional variations. This may be because of different environmental factors or may represent a different genetic predisposition.…”

Section: Discussionmentioning

confidence: 99%

Pattern of mismatch repair protein loss and its clinicopathological correlation in colorectal cancer in North India

et al. 2018

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Background: To determine the mismatch repair (MMR) protein loss in colorectal cancer (CRC) in north Indian patients and its clinicopathological correlation. Methods: A prospective study on patients with colorectal cancer from a tertiary level hospital conducted between May 2014 and June 2015. MMR protein loss was determined using immunohistochemistry for MLH1, MSH2, PMS2 and MSH6. Results: 52 patients (38 male and 14 females) of CRC, with median age of 52.5 years who underwent resection form the study group. 18 (35%) patients were < 50 years of age. Family history of malignancy was present in 3 (6 %) patients. A total of 15 (29%) patients had loss of MMR protein of which 7 (46%) were < 50 years. Most common MMR loss was combined loss of MSH2 + MSH6 [6 (11.5%)] followed by isolated loss of PMS2 [5 (9.6%)]. MMR protein loss was more frequent in patients with right side colon cancer [12 (42%)] compared to left [3 (13%)] (p = 0.033). MMR protein loss was seen in 11 (34%) out of 32 patients fulfilling the revised Bethesda criteria compared to 4 (20%) out of 20 patients who did not fulfil the criteria (p = 0.352). Conclusion: This study demonstrates high frequency of MMR protein loss in colorectal cancer in north Indian patients which was more common in right colon cancer. Many patients having MMR protein loss do not satisfy the revised Bethesda criteria and would have been missed if selective testing was done. Further research and larger studies are required to validate these findings and develop India specific clinical criteria.

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Section: Discussionmentioning

confidence: 99%

Pattern of mismatch repair protein loss and its clinicopathological correlation in colorectal cancer in North India

et al. 2018

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“…revealed that breast carcinoma was the leading cause of cancer in followed by lung, which was similar to the present study. [ 13 14 ] The prevalence of cancer for both the sites i.e., lung and breasts, was found to be higher in the present study when compared with the rest of the institutions. A study conducted by RA Badwe et al ., showed an increased incidence of lung and breast cancer over the years from 1988 to 2005.…”

Section: Discussionmentioning

confidence: 44%

Retrospective sequential trend analysis of neoplasms reported in a tertiary care hospital of district Etawah, Uttar Pradesh

Shukla

Sachan

Bajpai

et al. 2021

Journal of Family Medicine and Primary Care

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Introduction: An estimated 2.25 million new cancer cases with 7 lakh cancer deaths were reported, according to GLOBOCAN 2018 in India. There is a steady rise in cancer cases, but trends and patterns vary within the state depending on the geographic region. Objectives: To study the proportion and site-wise distribution of neoplasm reported at a tertiary care hospital in district Etawah, Uttar Pradesh, India. Material and Methods: A record based retrospective study was conducted at a tertiary care hospital in district Etawah, Uttar Pradesh. Total four years (from 2015 to 2018) hospital-based retrospective data were collected from the Medical Record Department. Identification and distribution of malignant neoplasm were done according to the WHO ICD-10 classification. Results: Total cases diagnosed with malignancy from January 2015 to December 2018 were 3614. Cancer cases reported over the years was 932 (25.8%) in 2015, 1031 (28.5%) cases in 2016, 897 (24.8%) in 2017 and 754 (20.9%) in 2018. It was found that breast carcinoma (24.0%) accounted for the maximum number of cases diagnosed, followed by lung carcinoma (10.9%), cervical cancer (8.7%), gall bladder carcinoma (8%), and oral cavity cancer (7.9%). Conclusion: The present study reveals that the malignancy of the breast is most common, followed by malignancies of lung, cervix, and gall bladder among the patients who were seeking care in a tertiary care hospital of the district Etawah Uttar Pradesh, India.

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“…Another hospital based study done in central Kerala in 2015 showed that the most common cancer identified was breast cancer (21%). 8 The most common warning sign identified in our study population was breast lump. As it was a questionnaire based study based on self-reports, an active screening in this area could bring more cases of breast lump.…”

Section: Discussionmentioning

confidence: 80%

Cancer burden and alarm signals: a community based study from Kerala, India

et al. 2020

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Background: Cancer is emerging as a major public health concern in many countries including India. Kerala state has the highest burden of cancer in the country. Objective of this study was to estimate the prevalence of diagnosed cancers, warning signs and selected risk factors of cancer in Kadapra Panchayath of Pathanamthitta district, Kerala.Methods: A total of 16,391 population was covered by door to door survey using a structured questionnaire. The questionnaire collected information on the sociodemographic variables of the residents, source of water supply, warning signs of cancer and details of diagnosed cancer cases.Results: The mean age of the population was 40.9+21 years. The prevalence of diagnosed cases of cancer in our study population was 776/100,000 population. Breast cancer was the most common cancer (43.5%) identified in the population. The prevalence of any warning sign among the study population was 220/100,000 population. Breast lump was the common warning sign identified. Increasing age and female gender were the factors found to be significantly associated with cancer.Conclusions: As prevalence of cancer was found to be high in this population, an active community based screening along with teaching self-breast examination to the women in the community are required. Improving community awareness could help in early diagnosis, treatment and prevention. Soil and water testing for carcinogens is recommended.

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Increasing cancer incidence in a tertiary care hospital in a developing country, India

Abstract: The findings of this study support that cancer incidence is increasing in India and more epidemiological studies are needed.

Cited by 12 publications

References 6 publications

Pattern of mismatch repair protein loss and its clinicopathological correlation in colorectal cancer in North India

Pattern of mismatch repair protein loss and its clinicopathological correlation in colorectal cancer in North India

Retrospective sequential trend analysis of neoplasms reported in a tertiary care hospital of district Etawah, Uttar Pradesh

Cancer burden and alarm signals: a community based study from Kerala, India

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