Increasing burden of urinary tract infections due to intrinsic colistin-resistant bacteria in hospitals in Marseille, France

Abat, Cédric; Desboves, Guillaume; Olaitan, Abiola Olumuyiwa; Chaudet, Hervé; Roattino, Nicole; Fournier, Pierre‐Edouard; Colson, Philippe; Raoult, Didier; Rolain, Jean‐Marc

doi:10.1016/j.ijantimicag.2014.10.010

Cited by 11 publications

(6 citation statements)

References 30 publications

(41 reference statements)

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“…Overuse of antimicrobial agents in the community without medical prescription and their low costs are thought to have contributed to the emergence and proliferation of antimicrobial resistance (8). It was previously observed that the increasing resistance rate to commonly used antimicrobial drugs could also play a ma-jor role in the occurrence of complicated and recurrent infections (9). Furthermore, differences in antibiotic resistance rates were documented in different geographical and regional locations (2,10).…”

Section: Introductionmentioning

confidence: 99%

Antibiotic Susceptibility Patterns of Uropathogens Isolated from Female Patients with Urinary Tract Infection in Duhok Province, Iraq

Naqid

Balatay

Saeed

et al. 2020

Jundishapur J Health Sci

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Background: Urinary Tract Infections (UTIs) are one of the most common bacterial infections worldwide. The study of bacterial uropathogens in a local area and their susceptibility to antimicrobial agents is required to determine empirical therapy. Objectives: This study aimed to assess the profile and antibiotic resistance patterns of bacteria, causing urinary infections isolated from female patients in Duhok province, Iraq. Methods: A total of 530 urine samples were collected from females clinically suspected of UTIs over three years between January 2017 and February 2020. The samples were inoculated directly on MacConkey and Blood agar media and then incubated aerobically for 24 h at 37°C. Samples that gave up colony counts of ≥ 105 CFU/mL were considered as positive growth. Purified colonies were identified through standard bacteriological tests, and their susceptibility to different antibiotics was determined using the Vitek-2 system. Results: Out of 530 urine samples, 450 (84.9%) contained Gram-negative bacteria, while the other 80 (15.1%) harbored Gram-positive bacteria. Escherichia coli was the most common uropathogenic isolate (58.5%), followed by K. pneumoniae (14.3%), Staphylococcus spp. (8.9%), P. mirabilis (6.6%), E. faecalis (3.2%), and S. agalactiae (3.02%). The majority of Gram-negative uropathogens were resistant to ampicillin, aztreonam, ceftriaxone, and cefepime and around 95% were sensitive to ertapenem and imipenem. Most Gram-positive isolates showed high resistance to benzylpenicillin, oxacillin, gentamicin, and erythromycin, and high susceptibility to linezolid, tigecycline, and nitrofurantoin. Conclusions: It was concluded from this study that E. coli is the predominant pathogen causing UTIs in female patients in Duhok province, Iraq. There were increasing antibiotic resistance rates, particularly to ampicillin, aztreonam, ceftriaxone, benzylpenicillin, and erythromycin. Therefore, empirical antibiotic therapy should be based on local sensitivity patterns rather than international guidelines.

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Section: Introductionmentioning

confidence: 99%

Antibiotic Susceptibility Patterns of Uropathogens Isolated from Female Patients with Urinary Tract Infection in Duhok Province, Iraq

Naqid

Balatay

Saeed

et al. 2020

Jundishapur J Health Sci

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“…aureus infections [ 27 ]. EPIMIC was also contributive in the retrospective analysis of intrinsic colistin-resistant bacteria in Marseille university hospitals in the context of an increasing burden of urinary tract infections [ 28 ]. Overall, between June 2013 and October 2014 (17 months), 0.46 non-recurrent alert 23 on abnormal events were detected per week.…”

Section: Resultsmentioning

confidence: 99%

EPIMIC: A Simple Homemade Computer Program for Real-Time EPIdemiological Surveillance and Alert Based on MICrobiological Data

et al. 2015

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Background and AimsInfectious diseases (IDs) are major causes of morbidity and mortality and their surveillance is critical. In 2002, we implemented a simple and versatile homemade tool, named EPIMIC, for the real-time systematic automated surveillance of IDs at Marseille university hospitals, based on the data from our clinical microbiology laboratory, including clinical samples, tests and diagnoses.MethodsThis tool was specifically designed to detect abnormal events as IDs are rarely predicted and modeled. EPIMIC operates using Microsoft Excel software and requires no particular computer skills or resources. An abnormal event corresponds to an increase above, or a decrease below threshold values calculated based on the mean of historical data plus or minus 2 standard deviations, respectively.ResultsBetween November 2002 and October 2013 (11 years), 293 items were surveyed weekly, including 38 clinical samples, 86 pathogens, 79 diagnosis tests, and 39 antibacterial resistance patterns. The mean duration of surveillance was 7.6 years (range, 1 month-10.9 years). A total of 108,427 Microsoft Excel file cells were filled with counts of clinical samples, and 110,017 cells were filled with counts of diagnoses. A total of 1,390,689 samples were analyzed. Among them, 172,180 were found to be positive for a pathogen. EPIMIC generated a mean number of 0.5 alert/week on abnormal events.ConclusionsEPIMIC proved to be efficient for real-time automated laboratory-based surveillance and alerting at our university hospital clinical microbiology laboratory-scale. It is freely downloadable from the following URL: http://www.mediterranee-infection.com/article.php?larub=157&titre=bulletin-epidemiologique (last accessed: 20/11/2015).

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“…unexplored factors could be responsible for this increase. Tigecycline exposure, for example, documented in our cohort in only three patients, was not evaluated in all epidemiological studies, and may have an effect on ICRE prevalence [4,5]. Using a caseecontrol design we aimed to control for other possible risk factors for ICRE infection besides colistin exposure.…”

Section: Discussionmentioning

confidence: 99%

“…Recent epidemiological studies describe a possible link between increased consumption of colistin and selection for inherently colistin-resistant Enterobacteriaceae (ICRE). Abat et al found a significant increase in isolation of ICRE between 2009 and 2013 in four centres in France, in parallel with an increase in colistin consumption [4]. Samonis et al described a significant association between colistin consumption and the isolation of hospitalacquired IRCE, although this association was not significant in the intensive care unit (ICU) [5].…”

Section: Introductionmentioning

confidence: 99%

Colistin exposure as a risk factor for infections caused by inherently colistin resistant Enterobacteriaceae—a case–control study

Drozdinsky

Ben‐Zvi

Kushnir

et al. 2018

Clinical Microbiology and Infection

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Exposure to colistin is associated with an increased risk of isolating an inherently colistin-resistant Enterobacteriaceae in patients with prolonged hospitalization. This should be taken into account while considering empirical therapy for such patients. Use of colistin should be judicious. The correlation between duration and magnitude of exposure and ICRE infection should be investigated in further studies.

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Increasing burden of urinary tract infections due to intrinsic colistin-resistant bacteria in hospitals in Marseille, France

Cited by 11 publications

References 30 publications

Antibiotic Susceptibility Patterns of Uropathogens Isolated from Female Patients with Urinary Tract Infection in Duhok Province, Iraq

Antibiotic Susceptibility Patterns of Uropathogens Isolated from Female Patients with Urinary Tract Infection in Duhok Province, Iraq

EPIMIC: A Simple Homemade Computer Program for Real-Time EPIdemiological Surveillance and Alert Based on MICrobiological Data

Colistin exposure as a risk factor for infections caused by inherently colistin resistant Enterobacteriaceae—a case–control study

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