Increasing Burden of Stroke: The Dijon Stroke Registry (1987–2012)

Guéniat, Julien; Brenière, Céline; Graber, Mathilde; Garnier, Lucie; Mohr, Sophie; Giroud, M.; Delpont, Benoît; Blanc-Labarre, Christelle; Durier, Jérôme; Giroud, Maurice; Béjot, Yannick

doi:10.1159/000486397

Cited by 29 publications

(19 citation statements)

References 23 publications

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“…This study was based on data from the Dijon Stroke Registry [4,5], an on-going population-based study that complies with the defined criteria for conducting "ideal" incidence stroke studies [6], and the guidelines for the reporting of incidence and prevalence studies in neuroepidemiology according to Standards of Reporting of Neurological Disorders [7]. Case-collection as well as adjudication procedures have been described extensively elsewhere [4,5].…”

Section: Study Population and Case-ascertainment Proceduresmentioning

confidence: 99%

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Impact of the Ageing Population on the Burden of Stroke: The Dijon Stroke Registry

et al. 2019

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Background: We aimed to evaluate the impact of the ageing population on temporal trends in burden of stroke and to provide projections for the coming years. Methods: Stroke cases (ischemic strokes, spontaneous intracerebral hemorrhages, or undetermined strokes) were prospectively identified between 1987 and 2015 in Dijon, France, using a population-based registry. Age-standardized incidence rates of first-ever and recurrent stroke were calculated, and their temporal trends were assessed using age- and sex-adjusted annual incidence rate ratios (RR). Results: The population of Dijon increased by 3.8% over time, with an increase by 28% in the number of residents aged ≥75 years. We recorded 5,899 strokes including 5,101 patients with a first-ever event. Incidence of first-ever stroke was stable both in people < 75 and ≥75 years old, but an increase in standardized incidence rates of total strokes was noted due to a rise in the incidence of recurrent stroke (from 4.7/100,000/year in 1987–1994 to 12.3/100,000/year in 2009–2015 in people < 75 years old, RR 1.036; p < 0.001; from 74/100,000/year in 1987–1994 to 200/100,000/year in 2009–2015 in people ≥75 years, RR 1.040; p < 0.001). The absolute number of first-ever strokes increased by 43%, and that of total stroke events rose by 58% over time, with a more pronounced increase in people ≥75 years old (+47 and +65% respectively). The annual number of patients who survived > 90 days after a first-ever stroke increased by 90%. According to demographic projections, the total number of strokes will increase by 55% (+65% patients ≥75 years, and +25% patients < 75 years) by 2,030 in Dijon. Conclusions: Ageing and growth of the population led to a rise in the absolute number of strokes, especially in the elderly, that is expected to increase dramatically in the coming years. Improved stroke care was accompanied with an increase in stroke survivors that contributed to a rise in recurrent events. Urgent action is needed to meet this epidemiological challenge.

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Section: Study Population and Case-ascertainment Proceduresmentioning

confidence: 99%

“…Case-collection as well as adjudication procedures have been described extensively elsewhere [4,5]. To ensure the exhaustiveness of case-collection, multiple overlapping sources of information are used.…”

Section: Study Population and Case-ascertainment Proceduresmentioning

confidence: 99%

Impact of the Ageing Population on the Burden of Stroke: The Dijon Stroke Registry

et al. 2019

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“…While some authors reported declining mortality following ICH in recent years [3,6,10], others found a decrease only in younger patients (<75 years of age) [12] or observed decreasing 30-day mortality but no changes within the first 48 hours from stroke onset [2]. Numerous studies, including a large meta-analysis by van Asch in 2010 that reached back into the 1980s, observed no change in mortality after ICH [1,7–9,11,13]. The aim of this analysis was to examine trends in ICH incidence, severity, complications, therapy and outcome of ICH from 2008 to 2016 in subjects registered in the Austrian Stroke Unit Registry (ASUR) [14–16].…”

Section: Introductionmentioning

confidence: 99%

Temporal trends in intracerebral hemorrhage: Evidence from the Austrian Stroke Unit Registry

et al. 2019

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BackgroundTo assess changes in frequency, severity, complications, therapy and outcome of intracerebral hemorrhage in patients treated in stroke units in Austria, we evaluated data from the Austrian Stroke Unit Registry between 2008 and 2016.Methods and findingsData of 6707 cases of ICH covering a time span of 9 years and including information on age, risk factors, pre-stroke modified Rankin Score (mRS), baseline stroke severity (NIHSS), complications, therapy, functional outcome, and mortality were extracted from the Austrian Stroke Unit Registry. A multivariate regularized logistic regression model and linear models for temporal dependence were computed for analyzing statistical inference and time trends. Bonferroni correction was applied to correct for multiple testing.Between 2008 and 2016, the proportion of ICH admissions to stroke units in Austria declined, with a shift among patients towards older age (>70 years, p = 0.04) and lower admission NIHSS scores. While no significant time trends in risk factors, pre-stroke mRS and medical complications were observed, therapeutic interventions declined significantly (p<0.001). Three-month mortality increased over the years independently (p = 0.003).ConclusionsDespite declining incidence and clinical severity of ICH we observed a clear increase in three-month mortality. This effect seems to be independent of predictors including age, admission NIHSS, pre-morbid MRS, or medical complications. The observations from this large retrospective database cohort study underline an urgent call for action in the therapy of ICH.

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“…Stroke is a global health problem, consisting the major reason of disability and death all over the world. It is well known that the older age, sex, and genetics are risk factors of stroke [ 1 ] however; according to Global Burden of Disease (GDB) 2013 STUDY, the burden of global stroke continues to increase globally. [ 2 ] Consequently, it is essential to find out other important genetic factors related to the mechanisms of the disease.…”

Section: Introductionmentioning

confidence: 99%

Relationship between short telomere length and stroke

et al. 2018

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Background:Several epidemiological studies had been carried out in different population cohorts to estimate the relationship between the shortened telomere length and stroke. However, the results still remained dispute. Consequently, we conducted this meta-analysis to estimate the relationship between them.Methods:PubMed, EMBASE, and Web of Science were systematically searched for related articles to evaluate the association between “stroke” and “telomere length. STATA 12.0 software was used to perform the meta-analysis. The Cochran Q test and inconsistency index (I2) were used to assess the heterogeneity. Begg funnel plot and Egger test were used to assess publication bias.Results:The meta-analysis was composed of 11 studies, consisting of 25,340 participants. We found a significant relationship between shortened telomere length and stroke (OR: 1.50, 95% CI: 1.13–2.0; P = .005); however, in the prospective and retrospective study subgroup, we did not find a statistical significant relationship between shortened telomere length and stroke (the prospective subgroup: OR: 1.41, 95% CI: 1–1.98; P = .051) (the retrospective subgroup: OR: 1.89, 95% CI: 0.96–3.72; P = .067).

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Increasing Burden of Stroke: The Dijon Stroke Registry (1987–2012)

Cited by 29 publications

References 23 publications

Impact of the Ageing Population on the Burden of Stroke: The Dijon Stroke Registry

Impact of the Ageing Population on the Burden of Stroke: The Dijon Stroke Registry

Temporal trends in intracerebral hemorrhage: Evidence from the Austrian Stroke Unit Registry

Relationship between short telomere length and stroke

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