Increasing BMI is associated with both endometrioid and serous histotypes among endometrial rather than ovarian cancers: a case-to-case study

Grandi, Giovanni; Perrone, Anna Myriam; Chiossi, Giuseppe; Friso, Stefano; Toss, Angela; Sammarini, Margaret; Facchinetti, Fabio; Botticelli, Laura; Palma, Federica; Iaco, Pierandrea De

doi:10.1016/j.ygyno.2019.04.684

Cited by 7 publications

(4 citation statements)

References 32 publications

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“…However, few markers are currently available and used in endometrial and ovarian cancer [27,28]. Over the years different risk factors have been associated with the development of EC rather than OC, such as hormonal therapy, smoke, obesity, the latter always associated with EC: a recent study has confirmed how an increase in BMI is associated with endometrial rather than ovarian cancer, but both serous and endometrioid histotypes [29]. Although CA125 is commonly used in the clinic for these reasons, it is endowed with low sensitivity and specificity [30,31].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic and prognostic role of TFF3, Romo-1, NF-кB and SFRP4 as biomarkers for endometrial and ovarian cancers: a prospective observational translational study

Turan¹,

Vitale

Kahramanoğlu

et al. 2022

Arch Gynecol Obstet

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Purpose This study aimed to evaluate trefoil factor 3 (TFF3), secreted frizzled-related protein 4 (sFRP4), reactive oxygen species modulator 1 (Romo1) and nuclear factor kappa B (NF-κB) as diagnostic and prognostic markers of endometrial cancer (EC) and ovarian cancer (OC). Methods Thirty-one patients with EC and 30 patients with OC undergone surgical treatment were enrolled together with 30 healthy controls in a prospective study. Commercial ELISA kits determined serum TFF-3, Romo-1, NF-кB and sFRP-4 concentrations. Results Serum TFF-3, Romo-1 and NF-кB levels were significantly higher in patients with EC and OC than those without cancer. Regarding EC, none of the serum biomarkers differs significantly between endometrial and non-endometrioid endometrial carcinomas. Mean serum TFF-3 and NF-кB levels were significantly higher in advanced stages. Increased serum levels of TFF-3 and NF-кB were found in those with a higher grade of the disease. Regarding OC, none of the serum biomarkers differed significantly among histological subtypes. Significantly increased serum levels of NF-кB were observed in patients with advanced-stage OC than those with stage I and II diseases. No difference in serum biomarker levels was found between those who had a recurrence and those who had not. The sensibility and specificity of these four biomarkers in discriminating EC and OC from the control group showed encouraging values, although no one reached 70%. Conclusions TFF-3, Romo-1, NF-кB and SFRP4 could represent new diagnostic and prognostic markers for OC and EC. Further studies are needed to validate our results.

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Section: Discussionmentioning

confidence: 99%

Diagnostic and prognostic role of TFF3, Romo-1, NF-кB and SFRP4 as biomarkers for endometrial and ovarian cancers: a prospective observational translational study

Turan¹,

Vitale

Kahramanoğlu

et al. 2022

Arch Gynecol Obstet

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“…This mechanism is best demonstrated by the Postmenopausal Estrogen/Progestin Intervention Trial which reported a 62% rate of endometrial hyperplasia over a period of three years (13). Interestingly, this pathogenic mechanism is responsible especially for the development of type I endometrial cancer (also known as endometroid endometrial cancer), this aspect being in fact a possible explanation for the association between type I endometrial cancer and obesity (14).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Bariatric Surgery on Premalignant Endometrial Pathology in Morbidly Obese Patients

Bălescu¹,

Bacalbaşa²,

Copăescu³

2019

chr

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“…So far, there is no doubt on the independent and positive correlation between increase in BMI and the risk of developing endometrial adenocarcinoma, particularly the type 1 or endometrioid variant. 31 These tumors are estrogen respondent and usually develop within a hyperplastic epithelium. Conversely, type 2 tumors are less responsive to estrogens and develop within an atrophic background.…”

Section: Obesity and Development Of Gynecologic Cancersmentioning

confidence: 99%

Obesity and gynecological cancers: A toxic relationship

Wichmann

Cuello

2021

Intl J Gynecology & Obste

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Despite the evidence supporting the relevance of obesity and obesity‐associated disorders in the development, management, and prognosis of various cancers, obesity rates continue to increase worldwide. Growing evidence supports the involvement of obesity in the development of gynecologic malignancies. This article explores the molecular basis governing the alteration of hallmarks of cancer in the development of obesity‐related gynecologic malignancies encompassing cervical, endometrial, and ovarian cancers. We highlight specific examples of how development, management, and prognosis are affected for each cancer, incorporate current knowledge on complementary approaches including lifestyle interventions to improve patient outcomes, and highlight how new technologies are helping us better understand the biology underlying this neglected pandemic.

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Increasing BMI is associated with both endometrioid and serous histotypes among endometrial rather than ovarian cancers: a case-to-case study

Cited by 7 publications

References 32 publications

Diagnostic and prognostic role of TFF3, Romo-1, NF-кB and SFRP4 as biomarkers for endometrial and ovarian cancers: a prospective observational translational study

Diagnostic and prognostic role of TFF3, Romo-1, NF-кB and SFRP4 as biomarkers for endometrial and ovarian cancers: a prospective observational translational study

The Effect of Bariatric Surgery on Premalignant Endometrial Pathology in Morbidly Obese Patients

Obesity and gynecological cancers: A toxic relationship

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