Increasing biosensor response through hydrogel thin film deposition: Influence of hydrogel thickness

Montero, Laura; Gabriel, Gemma; Guimerà‐Brunet, Anton; Villa, Rosa; Gleason, Karen K.; Borrós, Salvador

doi:10.1016/j.vacuum.2012.06.002

Cited by 19 publications

(13 citation statements)

References 21 publications

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“…This creates changes in the mechanical properties, protein adsorption capabilities and hydrophilicity of the material. This dynamic property is useful for many applications (i.e., biotechnology,67, 87, 94 stimuli‐responsive coatings,95, 96 sensors97, 98, 99 etc.). Some hydrogels have similar water content to human tissue and exhibit excellent biocompatibility.…”

Section: Chain Growth Polymerization: Icvdmentioning

confidence: 99%

“…Ozaydin‐Ince and coworkers used an iCVD templating technique to create “microworm” optode sensors for in vivo measurement of sodium concentration (Figure 15a–c) 99. iCVD PHEMA coatings have also been used to increase device response in impedance biosensors 98. The hydrogel coatings protect the electrodes, enhance their surface resistance, and improve the quality of the electrode‐electrolyte interface.…”

Section: Responsive Icvd Surfaces and Devicesmentioning

confidence: 99%

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25th Anniversary Article: CVD Polymers: A New Paradigm for Surface Modifi cation and Device Fabrication

et al. 2013

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Well-adhered, conformal, thin (<100 nm) coatings can easily be obtained by chemical vapor deposition (CVD) for a variety of technological applications. Room temperature modification with functional polymers can be achieved on virtually any substrate: organic, inorganic, rigid, flexible, planar, three-dimensional, dense, or porous. In CVD polymerization, the monomer(s) are delivered to the surface through the vapor phase and then undergo simultaneous polymerization and thin film formation. By eliminating the need to dissolve macromolecules, CVD enables insoluble polymers to be coated and prevents solvent damage to the substrate. CVD film growth proceeds from the substrate up, allowing for interfacial engineering, real-time monitoring, and thickness control. Initiated-CVD shows successful results in terms of rationally designed micro- and nanoengineered materials to control molecular interactions at material surfaces. The success of oxidative-CVD is mainly demonstrated for the deposition of organic conducting and semiconducting polymers.

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Section: Chain Growth Polymerization: Icvdmentioning

confidence: 99%

Section: Responsive Icvd Surfaces and Devicesmentioning

confidence: 99%

25th Anniversary Article: CVD Polymers: A New Paradigm for Surface Modifi cation and Device Fabrication

et al. 2013

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“…The fast and reversible changes in the thickness of p(HEMA) were used in an impedance sensor to control the passage of the analyte. 57 By regulating the cross-link density of the p(HEMA) hydrogels, it is possible to systematically control the mesh size of the polymer and therefore allow the selective permeation of some analytes while preventing the passage of other species (e.g. foulant in biosensing applications).…”

Section: Hydrogels For Biotechnology and Drug Deliverymentioning

confidence: 99%

Smart surfaces by initiated chemical vapor deposition

Coclite

2013

Surface Innovations

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The ability to modify the surface of materials with functional and responsive coatings is a powerful tool for the fabrication of smart devices for biotechnology, microfluidics, membrane technology, sensors and drug delivery systems. A recently developed method for the deposition of polymeric thin films, called initiated chemical vapor deposition (iCVD) is reviewed here. The authors will describe the high versatility of iCVD in driving application-specific properties into the material, creating a platform for the implementation of polymeric coatings into device fabrication. The significant impact of this polymerization technique lies in the possibility of obtaining polymers with chemical structure similar to the one of the polymers synthesized by conventional techniques with the advantages of a solvent-free deposition, which is totally substrate independent. Deposition has been demonstrated on paper, metal, plastics, porous substrates and very recently liquids. Tuning the process parameters allows to obtain controlled and uniform thickness over 3D substrates. Future outlook and iCVD scale-up approaches are also discussed.

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“…[ 41 , 42 ] In addition, an iCVD pHEMA coating was used to increase the response of an impedance biosensor. [ 43 ] The rapid and reversible swelling of the hydrogel in solution allowed the passage of the analyte, altering the impedance of the device.…”

Section: Tailored Surfaces and Interfacesmentioning

confidence: 99%

Chemical Vapor Deposition for Solvent‐Free Polymerization at Surfaces

Yagüe

Coclite

Petruczok

et al. 2012

Macro Chemistry & Physics

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Chemical vapor deposition (CVD) methods are a powerful technology for engineering surfaces. When CVD is combined with the richness of organic chemistry, the resulting polymeric coatings, deposited without solvents, represent an enabling technology in many different fi elds of application. This article focuses on initiated chemical vapor deposition (iCVD), a new technique that utilizes benign reaction conditions to yield conformal and functional polymer thin fi lms. The latest achievements in coating surfaces and 3D substrates with functional materials, and the use of the technique for biotechnology and selective permeation applications are reviewed, and future directions for iCVD technology are discussed.

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Increasing biosensor response through hydrogel thin film deposition: Influence of hydrogel thickness

Cited by 19 publications

References 21 publications

25th Anniversary Article: CVD Polymers: A New Paradigm for Surface Modifi cation and Device Fabrication

25th Anniversary Article: CVD Polymers: A New Paradigm for Surface Modifi cation and Device Fabrication

Smart surfaces by initiated chemical vapor deposition

Chemical Vapor Deposition for Solvent‐Free Polymerization at Surfaces

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