Increasing adipocyte number and reducing adipocyte size: the role of retinoids in adipose tissue development and metabolism

Wang, Bo; Du, Min

doi:10.1080/10408398.2023.2227258

Cited by 4 publications

(4 citation statements)

References 214 publications

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“…Furthermore, due to the known dose-dependent, hepatotoxic effects of synthetic forms of this vitamin, recommending suitable doses poses a challenge [112]. On the other hand, maintaining adequate vitamin A levels may be crucial for the health of adipose tissue since this substance was shown to promote angiogenesis and de novo adipogenesis [113]. Healthy adipose tissue contains more abundant, well-vascularized adipocytes for fat storage [114].…”

Section: Effects Of Micronutrient Supplementation On Lipid Homeostasismentioning

confidence: 99%

“…Such a structure, to a certain extent, protects adipocytes from overgrowth and inflammation, which are risk factors contributing to the development of metabolic dysfunctions, especially insulin resistance [98]. Since the formation of adipocytes is most intense during fetal development and their number gets established in childhood and early adulthood, providing vitamin A adequacy might be especially crucial in early life [113].…”

Section: Effects Of Micronutrient Supplementation On Lipid Homeostasismentioning

confidence: 99%

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The Importance of Micronutrient Adequacy in Obesity and the Potential of Microbiota Interventions to Support It

Rudzka,

Kapusniak,

Zielińska

et al. 2024

Applied Sciences

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Micronutrient deficiencies co-occur with obesity throughout the world. While many factors may contribute to this, microbiota dysbiosis is certainly one that has received a lot of attention in recent years. This work aimed to review the current state of knowledge on the role of micronutrients in obesity and the effects of interventions in microbiota on the micronutrient status of humans. Gathered evidence suggested that the supplementation of most of the deficient micronutrients for people with excess weight may have a considerable, positive impact on lipid and glucose homeostasis and a small effect on weight loss. Interestingly, the doses of micronutrient supplementation that allowed for achieving the best results for most of the minerals and vitamins exceeded the tolerable upper intake levels. To avoid negative effects associated with an overdose of vitamins and minerals, applying microbiota interventions could be considered. Pro- and prebiotics were shown to improve the micronutrient status of humans, and several publications indicated that when applied together with vitamins and minerals, they could give greater benefits than each of these treatments alone. Therefore, supplementation with vitamins, minerals, and pro/pre/synbiotics in obesity treatment plans may be recommended; however, further research is required to mitigate risks and optimize the effects achieved.

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Section: Effects Of Micronutrient Supplementation On Lipid Homeostasismentioning

confidence: 99%

Section: Effects Of Micronutrient Supplementation On Lipid Homeostasismentioning

confidence: 99%

The Importance of Micronutrient Adequacy in Obesity and the Potential of Microbiota Interventions to Support It

Rudzka,

Kapusniak,

Zielińska

et al. 2024

Applied Sciences

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“…Additionally, a leucine-restricted diet alleviates obesity-related problems, improves insulin resistance, promotes white adipose tissue browning, upregulates the expression of neurotrophic factors, and inhibits neural inflammation in the brain region associated with memory functions. It also changes the intestinal microflora by reducing the number of inflammationassociated bacteria and increasing the number of short-chain fatty acids associated with the growth of some bacteria; consequently, it may alleviate some obesity-related problems [85].…”

Section: Amino Acidsmentioning

confidence: 99%

Rubi idaei fructus as a Source of Bioactive Chemical Compounds with an Important Role in Human Health and Comparison of the Antioxidant Potential of Fruits and Juice of Three Repeat-Fruiting Rubus idaeus L. Cultivars

Chwil,

Matraszek-Gawron,

Kostryco

2023

Metabolites

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Rubi idaei fructus is a source of nutritionally important bioactive chemical compounds, mainly antioxidants, which strengthen the immune system and can be used in the prophylaxis and adjuvant therapies of many oxidative stress-induced diseases. There are no literature reports presenting a comprehensive comparative analysis of the antioxidant activity and nutritionally relevant metabolites contained in the fruits of repeat-fruiting raspberry cultivars, which are commonly grown in Europe. The aim of this study was to carry out a comparative analysis of the antioxidant potential (Folin–Ciocalteu, DPPH, FRAP), the content of selected primary and secondary metabolites, and the qualitative and quantitative composition of amino acids and fatty acids in the fruits of R. idaeus cv. ‘Pokusa’, ‘Polana’, and ‘Polka’. The fruits of the analyzed cultivars have a low caloric value (171–219 kcal/100 g); low content of available carbohydrates (6–6.6%) and total carbohydrates (3.4–4.8%); and high levels of dietary fiber (4.7–5.8%), vitamin C (22.8–27 mg/100 g), anthocyanins (25.1–29.6 mg/100 g), and flavonoids (0.5–2.6 mg/100 g). The fruits were found to contain valuable unsaturated fatty acids (35–60%), especially MUFAs with dominant oleic, elaidic, palmitic, and erucic acids and PUFAs (α-linolenic, eicosapentaenoic, and linoleic acids). MUFAs from the ω-9 group accounted for 12–18%, whereas the content of PUFAs from the ω-3 and ω-6 groups was in the range of 15–23 and 6–21%, respectively. Exogenous amino acids, accounting for 56–62%, were dominated by leucine, phenylalanine, and lysine. The following order of the total polyphenolic content was established in the fresh fruit juice from the analyzed cultivars: ‘Pokusa’ < ‘Polana’ < ‘Polka’. The different antioxidant capacity assays used in the study confirmed the high antioxidant potential of the fruits and fresh juice from the three R. idaeus cultivars. This indicates that raspberry fruits can serve as a source of nutrients and can be used as a valuable supplement in a healthy human diet and a raw material in the pharmaceutical and cosmetic industries.

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“…Adipocytes are the most common cells in the human body and serve dual roles of energy storage sites and regulators of physiological processes. , They not only maintain energy metabolism, nutritional homeostasis, and tissue homeostasis in the body but are also involved in important endocrine functions. , Adipocyte differentiation is a physiological process involving differentiation from mesenchymal stem cells (MSCs) to mature adipocytes . In addition, a balance is maintained between adipogenic and osteogenic differentiation of mesenchymal bone marrow stem cells (BMSCs) .…”

Section: Introductionmentioning

confidence: 99%

LOC646762 Is Involved in Adipogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells

Shao,

Xiong,

Liu

et al. 2024

ACS Omega

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Long noncoding RNA (lncRNA) has been shown to participate in adipogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs). In this study, we aimed to investigate the role of lncRNA-LOC646762 in adipogenic differentiation of BMSCs. Transcriptome sequencing revealed a positive correlation between LOC646762 transcription and expression of adipogenic marker genes in adipogenic differentiation. Moreover, LOC646762 overexpression did not negatively impact the cell proliferation of BMSCs. Besides, LOC646762 plays a crucial role in adipogenic differentiation, as evidenced by its positive correlation with adipogenic marker gene expression. Its possible interaction with its proposed target C/EBPβ suggests its involvement in essential pathways governing adipogenesis. Collectively, our study outcomes provide valuable insights into the molecular mechanisms underlying the adipogenic differentiation of BMSCs and lay a strong foundation for further research in regenerative medicine.

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Increasing adipocyte number and reducing adipocyte size: the role of retinoids in adipose tissue development and metabolism

Cited by 4 publications

References 214 publications

The Importance of Micronutrient Adequacy in Obesity and the Potential of Microbiota Interventions to Support It

The Importance of Micronutrient Adequacy in Obesity and the Potential of Microbiota Interventions to Support It

Rubi idaei fructus as a Source of Bioactive Chemical Compounds with an Important Role in Human Health and Comparison of the Antioxidant Potential of Fruits and Juice of Three Repeat-Fruiting Rubus idaeus L. Cultivars

LOC646762 Is Involved in Adipogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells

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