Increasing accuracy of antenatal ultrasound diagnosis of cleft lip with or without cleft palate, in cases referred to the North Thames London Region

Abstract

Objectives To determine the accuracy of antenatal ultrasound diagnosis of cleft lip with or without cleft palate (CL ± P) and isolated cleft palate (CP). Methods

Antenatal detection of cleft lip with or without cleft palate: incidence of associated chromosomal and structural anomalies

“…Overall, 39.2% (87/222) of cases of unilateral or bilateral CL ± P were not detected in the antenatal period. This is similar to recently published data by Demircioglu et al 11. Chmait et al 10 reported a 21.6% rate of undiagnosed associated structural abnormalities.…”

Cleft Lip and Palate Nutritional Assessment and Feeding challenges

“…Success could be achieved via teaching the parents and providing support to face such challenges 10,11,12,13 . In this study the prenatal diagnosis was confirmed in 37% of the affected cases, that rate was coincide with several previous studies which showed a range from 19% to 70% with correspondence to the design of the study 14,15,16,17 .…”

Enlarged nuchal translucency in chromosomally normal fetuses: strong association with orofacial clefts

“…An isolated orofacial cleft is considered to be an anomaly of variable severity, but with a generally good prognosis. Prenatal diagnosis is important to exclude associated anomalies, to define the need for karyotyping or other genetic investigations (for example, to search for 22q11 deletion) and to counsel parents about the prognosis and management25. Prenatal detection enables parents to be adequately prepared for the special feeding requirements of their baby.…”