Increases in orbitofrontal cortex thickness following antidepressant treatment are associated with changes in resting state autonomic function in adolescents with major depression – Preliminary findings from a pilot study

Koenig, Julian; Schreiner, Melinda Westlund; Klimes‐Dougan, Bonnie; Ubani, Benjamin; Mueller, Bryon A.; Lim, Kelvin O.; Kaess, Michael; Cullen, Kathryn R.

doi:10.1016/j.pscychresns.2018.08.013

Cited by 31 publications

(14 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Here's the good news: these phenomena are reversible! In line with research in adults (Chambers & Allen, 2002; Jang, Hwang, Padhye, & Meininger, 2017), we have previously shown, that HRV re‐increases following antidepressant treatment with selective serotonin reuptake inhibitors in adolescents with depression (Koenig et al, 2018). Clinical improvement (decrease in depression severity) was associated with increased HRV and decreased HR.…”

Section: A Dynamical Model Of Neurovisceral Integrationsupporting

confidence: 88%

Neurovisceral regulatory circuits of affective resilience in youth

Koenig

2020

Psychophysiology

Self Cite

View full text Add to dashboard Cite

The Neurovisceral Integration Model (NIM) is one of the most influential psychophysiological models addressing the interplay between the autonomic (ANS) and central nervous system (CNS). In their groundbreaking conceptual work, integrating autonomic, attentional, and affective systems into a functional and structural network, Thayer & Lane laid the foundation for empirical research in the past two decades. The present paper provides a principal outline aiming to reflect and further elaborate on the model from a dynamic developmental perspective. The central question at hand is, how does neurovisceral integration develop (early in life)? By reviewing the existing evidence, it is illustrated that key components of the model, both, on a physiological and psychological level, undergo extensive change early in the course of life. This sensitive period of human development seems key for our understanding of the integrated action of the ANS and CNS in emotion across the lifespan. Early life events may interfere with the fine-tuned interplay of this shared neural circuitry resulting in long-term dysfunction and psychiatric illness. In the absence of longitudinal data covering the entire co-development of the ANS and CNSfrom early childhood to adolescence into early adulthood, it is suggested, that vagal activity and its normative increase in adolescence is a key premise for normative brain development on a structural and functional level, subsequent psychological functioning and adaptive regulation. Implications from this dynamic perspective and suggestions for future research in the field of developmental psychophysiology are discussed. K E Y W O R D Sadolescence, brain development, emotion regulation, heart rate variability, neurovisceral integration, psychopathology 2 of 18 | KOENIG

show abstract

Section: A Dynamical Model Of Neurovisceral Integrationsupporting

confidence: 88%

Neurovisceral regulatory circuits of affective resilience in youth

Koenig

2020

Psychophysiology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Multi-modal assessments of autonomic nervous system function showed that acute tVNS was associated with an increase in HRV and a decrease of HR only in controls. The absence of effects in patients with MDD suggests that ANS regulation is not susceptible to acute-tVNS, but may require prolonged therapeutic intervention to show meaningful effects (Koenig et al, 2018 ). In line with the findings of prior meta-analyses (Kemp et al, 2010 ; Koenig, Kemp, Beauchaine, Thayer, & Kaess, 2016 ), patients with MDD from the present sample showed greater HR and lower HRV compared to controls.…”

Section: Discussionmentioning

confidence: 99%

Effects of acute transcutaneous vagus nerve stimulation on emotion recognition in adolescent depression

et al. 2019

Self Cite

View full text Add to dashboard Cite

Background Transcutaneous vagus nerve stimulation (tVNS) is a promising therapeutic option for major depressive disorder (MDD) in adults. Alternative third-line treatments for MDD in adolescents are scarce. Here we aimed to assess the effects of acute tVNS on emotion recognition in adolescents with MDD. Methods Adolescents (14–17 years) with MDD (n = 33) and non-depressed controls (n = 30) received tVNS or sham-stimulation in a cross-sectional, case–control, within-subject cross-randomized controlled trial, while performing different tasks assessing emotion recognition. Correct responses, response times, and errors of omission and commission on three different computerized emotion recognition tasks were assessed as main outcomes. Simultaneous recordings of electrocardiography and electro dermal activity, as well as sampling of saliva for the determination of α-amylase, were used to quantify the effects on autonomic nervous system function. Results tVNS had no effect on the recognition of gradually or static expressed emotions but altered response inhibition on the emotional Go/NoGo-task. Specifically, tVNS increased the likelihood of omitting a response toward sad target-stimuli in adolescents with MDD, while decreasing errors (independent of the target emotion) in controls. Effects of acute tVNS on autonomic nervous system function were found in non-depressed controls only. Conclusions Acute tVNS alters the recognition of briefly presented facial expressions of negative valence in adolescents with MDD while generally increasing emotion recognition in controls. tVNS seems to specifically alter early visual processing of stimuli of negative emotional valence in MDD. These findings suggest a potential therapeutic benefit of tVNS in adolescent MDD that requires further evaluation within clinical trials.

show abstract

“…In the previous cortical thickness study using the same dataset, the increased thickness of the left medial orbitofrontal cortex and the correlations between clinical improvement and increased cortical thickness of the left lateral orbitofrontal cortex and superior frontal cortex were found [ 107 ], which potentially relate to increased connectivity. The bilateral middle temporal gyrus also shows a decreased clustering coefficient and local efficiency but not the nodal centrality.…”

Section: Discussionmentioning

confidence: 95%

Effect of SSRIs on Resting-State Functional Brain Networks in Adolescents with Major Depressive Disorder

Chu

Parhi

Schreiner

et al. 2021

JCM

Self Cite

View full text Add to dashboard Cite

Investigation of brain changes in functional connectivity and functional network topology from receiving 8-week selective serotonin reuptake inhibitor (SSRI) treatments is conducted in 12 unmedicated adolescents with major depressive disorder (MDD) by using wavelet-filtered resting-state functional magnetic resonance imaging (fMRI). Changes are observed in frontal-limbic, temporal, and default mode networks. In particular, topological analysis shows, at the global scale and in the 0.12–0.25 Hz band, that the normalized clustering coefficient and smallworldness of brain networks decreased after treatment. Regional changes in clustering coefficient and efficiency were observed in the bilateral caudal middle frontal gyrus, rostral middle frontal gyrus, superior temporal gyrus, left pars triangularis, putamen, and right superior frontal gyrus. Furthermore, changes of nodal centrality and changes of connectivity associated with these frontal and temporal regions confirm the global topological alternations. Moreover, frequency dependence is observed from FDR-controlled subnetworks for the limbic-cortical connectivity change. In the high-frequency band, the altered connections involve mostly frontal regions, while the altered connections in the low-frequency bands spread to parietal and temporal areas. Due to the limitation of small sample sizes and lack of placebo control, these preliminary findings require confirmation with future work using larger samples. Confirmation of biomarkers associated with treatment could suggest potential avenues for clinical applications such as tracking treatment response and neurobiologically informed treatment optimization.

show abstract

Increases in orbitofrontal cortex thickness following antidepressant treatment are associated with changes in resting state autonomic function in adolescents with major depression – Preliminary findings from a pilot study

Cited by 31 publications

References 56 publications

Neurovisceral regulatory circuits of affective resilience in youth

Neurovisceral regulatory circuits of affective resilience in youth

Effects of acute transcutaneous vagus nerve stimulation on emotion recognition in adolescent depression

Effect of SSRIs on Resting-State Functional Brain Networks in Adolescents with Major Depressive Disorder

Contact Info

Product

Resources

About