Increases in coronary vascular resistance related to high arterial oxygen tension in dogs.

Ishikawa, Kinji; Kanamasa, Ken; Yamakado, Tetsu; Kohashi, Yasuyuki; Kato, Arata; Otani, Shohei; Hattori, Takeo; Katori, Ryo

doi:10.1253/jcj.44.749

Cited by 8 publications

(1 citation statement)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a later study using a thermographic technique, Maim et al (20), in experiments on dogs subjected to coronary artery occlusion, found evidence for an enlargement of the ischemic area as an effect of pure oxygen breathing. Several investiga-tions indicate negative effects of oxygen administration upon various hemodynamic parameters (8,9,30,36,37). However, oxygen is still widely administered.…”

Section: Introductionmentioning

confidence: 99%

Tissue oxygen pressure in normal myocardium and across the border zone during coronary artery occlusion in the pig. Effects of different arterial oxygen pressures

Walfridsson

Lund

1990

Basic Res Cardiol

View full text Add to dashboard Cite

Tissue oxygen pressure (ptO2) in the pig heart was measured with two different oxygen electrodes: We measured ptO2 in normal myocardium with the MDO electrode while oxygen gradients across the border zone, during acute coronary artery occlusion, were measured with an array-multiwire-electrode (AME). The aim of the study was to investigate the effects of increased arterial oxygen pressure (paO2) during repeated, short-lasting (5 min) coronary artery occlusions. During ventilation with an inspired oxygen fraction (FIO2) of 0.3 the ptO2 levels in normal myocardium increased significantly, while the distribution type of ptO2 values remained normal. During ventilation with FIO2 0.7 there was an uneven distribution of ptO2 values indicating microcirculatory disturbances, however, no ischemic values were seen. We found no indication for any influence on the ptO2 of the border zone.

show abstract

Section: Introductionmentioning

confidence: 99%

Tissue oxygen pressure in normal myocardium and across the border zone during coronary artery occlusion in the pig. Effects of different arterial oxygen pressures

Walfridsson

Lund

1990

Basic Res Cardiol

View full text Add to dashboard Cite

show abstract

The effect of CO2- and O2-gas mixtures on laser Doppler measured cochlear and skin blood flow in guinea pigs

et al. 1991

View full text Add to dashboard Cite

The effects of carbogen (5% CO2: 95% O2) 10% CO2-in-air and 100% O2 on cochlear blood flow (CBF), skin blood flow (SBP), blood pressure (BP) and arterial blood gases were investigated in the anesthetized, respired or self-respiring guinea pig. In respired animals, CBF and SBF were increased with carbogen and 10% CO2-in-air and decreased with O2. BP was elevated with each gas. In freely breathing animals, only 10% CO2-in-air caused a small increase in CBF; both carbogen and O2 caused CBF to decrease. SPF changes were similar in form, but larger than those seen in respirated subjects. No consistent change in BP was seen during breathing of these mixtures. Arterial PO2 was increased by carbogen and 10% CO2-in-air for both groups. PCO2 increased for both CO2 gas mixtures during forced respiration; but in free-breathing animals PCO2 only increased for 10% CO2-in-air (normal PCO2 values were maintained with carbogen thorough increased breathing rate). The observed changes in CBF were consistent with a balance between a combined vasoconstrictive effect of PO2 and vasodilation effect of PCO2 on cochlear vessels. Analysis of cochlear vascular conductivity (CBF/BP) indicated that vasodilation was significant only with 10% CO2-in-air in respirated animals. In all other conditions the increased CBF apparently reflects the increase profusion pressure associated with respiration of each gas. For clinical purposes, while carbogen does not appear to directly cause vasodilation of cochlear vessels it does lead to an increased oxygenation of the cochlea blood and would appear to avoid the cochlear vasoconstriction caused by 100% O2.

show abstract

Myocardial Oxygen Handling and Metabolic Function of Ex-Situ Perfused Human Hearts from Circulatory Death Donors

Amesz,

Langmuur,

Bierhuizen

et al. 2024

JHLT Open

View full text Add to dashboard Cite

Increases in coronary vascular resistance related to high arterial oxygen tension in dogs.

Cited by 8 publications

References 14 publications

Tissue oxygen pressure in normal myocardium and across the border zone during coronary artery occlusion in the pig. Effects of different arterial oxygen pressures

Tissue oxygen pressure in normal myocardium and across the border zone during coronary artery occlusion in the pig. Effects of different arterial oxygen pressures

The effect of CO2- and O2-gas mixtures on laser Doppler measured cochlear and skin blood flow in guinea pigs

Myocardial Oxygen Handling and Metabolic Function of Ex-Situ Perfused Human Hearts from Circulatory Death Donors

Contact Info

Product

Resources

About