Increases in both cerebral glucose utilization and blood flow during execution of a somatosensory task

Ginsberg, Myron D.; Chang, Joshua; Kelley, Roger E.; Yoshii, Fumihito; Barker, Warren W.; Ингенито, Г.; Boothe, Thomas E.

doi:10.1002/ana.410230208

Cited by 86 publications

(27 citation statements)

References 33 publications

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“…Therefore, the caveat remains that the reported differences between right and left hemisphere activation were related to factors other than hemispheric dominance. Ginsberg et al (1988), using a complex somatosensory discriminative task, observed differences in CMR glu induced by the movements of the right and the left hands. It remains difficult to use 18F-fluorodeoxyglucose for activation studies.…”

Section: Discussionmentioning

confidence: 99%

Effect of Side and Rate of Stimulation on Cerebral Blood Flow Changes in Motor Areas during Finger Movements in Humans

Sabatini

Chollet

Rascol

et al. 1993

J Cereb Blood Flow Metab

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Summary: We measured, using single photon emission computed tomography, the regional CBF (rCBF) changes in the motor areas of 24 right-handed normal volunteers during the performance of a motor task consisting of se quential finger-to-thumb opposition. Twelve of them per formed the task with their right and their left hands con secutively with a fast frequency and large amplitude. The other 12 subjects performed the task with their right hand only at a slow frequency and small amplitude. The con tralateral primary sensorimotor area (SlIMl), supplemen tary motor area (SMA), and ipsilateral cerebellum were significantly activated during right and left finger move ments performed at fast frequency and large amplitude.It is possible in humans to map the active brain areas involved in voluntary movements by measur ing regional CBF (rCBF) changes using the nonto mographic \33Xe technique (Olesen, 1971;Roland et al., 1980), single photon emission computed tomog raphy (SPECT) (Lauritzen et al., 1981), or more recently positron emission tomography (Fox et al., 1985; Colebatch et al., 1990; Deiber et al., 1991). Several studies have underlined the physiological role of the contralateral primary sensorimotor area (SlIM1) in the execution of movement and support Received September 4, 1992; final revision received January 6, 1993; accepted January 7, 1993.Address correspondence and reprint requests to Dr. F. Chollet at Department of Neurology, Hopital Universitaire Purpan, place Baylac, 31059 Toulouse, France.Abbreviations used: CM, canthomeatal plane; gCBF, global CBF; M task; motor task; MANOV A, multivariate analysis of variance; rCBF, regional CBF; ROI, region of interest; SllMl, primary sensorimotor area; SMA, supplementary motor area; SPECT, single photon emission computed tomography. 639No significant difference was found between the rCBF changes induced by the right dominant and left nondomi nant hands. When the task was performed with a slow rate and small amplitude, the SMA was significantly ac tivated while no significant changes were observed in the contralateral S 11M I or in the ipsilateral cerebellum. These results demonstrate (a) that hand dominance evokes no differences in the activation of the main motor areas and (b) that the frequency and amplitude of the movement have a major effect on the quantitative and qualitative aspect of activation of motor areas in humans.

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Section: Discussionmentioning

confidence: 99%

Effect of Side and Rate of Stimulation on Cerebral Blood Flow Changes in Motor Areas during Finger Movements in Humans

Sabatini

Chollet

Rascol

et al. 1993

J Cereb Blood Flow Metab

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“…With this technique, we observed a 16.9% increase in local cerebral glucose utilization and a 26.6% increase in local cerebral blood flow in normals. 14 The video game that we employed is obviously a crude task that would be expected to activate a number of different areas of the cerebral cortex as it requires attention, visual input, visuospatial orientation, and fine motor activity. Its most attractive feature was that successful manipulation of the joystick, resulting in progressive removal of bricks from the wall, routinely resulted in prolonged attention.…”

Section: Discussionmentioning

confidence: 99%

Transcranial Doppler assessment of cerebral flow velocity during cognitive tasks.

Kelley

Chang

Scheinman

et al. 1992

Stroke

109

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Background and Purpose: The purpose of this study was to assess the ability of transcranial Doppler ultrasonography to detect selective circulatory changes during cognitive activity.Methods: We measured cerebral artery flow velocity in 21 normal volunteers by transcranial Doppler ultrasonography during rest followed by cerebral activation. Mean and peak systolic flow velocities of the anterior, middle, and posterior cerebral arteries were measured during the performance of a commercial video game. We also measured flow velocity of the anterior cerebral arteries in 18 subjects during a mental arithmetic task. Serial measurements of the right and left sides were made with a headband with two probes.Results: We observed a global increase in the flow velocity above baseline measurements during task performance. During the video game, both middle cerebral arteries (f=2.6,p=0.02 for the left; f=33,p=0.004 for the right) and the left posterior cerebral artery (/=2.2,p=0.004) had selective increase in mean flow velocity compared with the ipsilateral anterior cerebral artery. This selective activation was most prominent in the right middle cerebral artery, which had a greater degree of activation than the right posterior cerebral artery (f=2.8,p=0.013). We did not observe a statistically significant difference between the right and left middle cerebral arteries, but there was a trend toward a greater activation on the right for both the mean velocity (t=1.7, p=0.098) and the peak velocity (f=1.9,p=0.079).Conclusions: Our preliminary investigation suggests that this noninvasive technique has the potential to correlate selective cerebral artery flow dynamics with cognitive activity. (Stroke 1992^23:9-14)

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“…Stimulation-induced changes in CMRO 2 , CMR glc , and CBF in the awake human brain from PET studies are shown. [12][13][14][15][16][17][18][19][20][21][22][23] Inset shows distribution of ⌬CMRO 2 /CMRO 2 , ⌬CMR glc /CMR glc , and ⌬CBF/CBF values from the PET studies (Table); exact values and their implications are discussed elsewhere. 24,25 The difference between changes in CMR glc and CMRO 2 (ie, ⌬CMR glc /CMR glc Ϫ⌬CMRO 2 /CMRO 2 on the vertical axis) reflects the degree of glucose oxidation; the lower the difference is, the greater is the degree of glucose oxidation (Equation 1).…”

Section: Physiology Of Neuroimagingmentioning

confidence: 99%

Neuroimaging With Calibrated fMRI

Hyder

2004

Stroke

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Abstract-The conventional functional MRI (fMRI) map offers information indirectly about localized changes in neuronal activity because it reflects changes in blood oxygenation, not actual neuronal activity. To provide a neurophysiological basis of fMRI, researchers have used electrophysiology to show correlations of fMRI and electric signals. However, quantitative interpretation of the degree to which neuronal activity has changed still cannot be made from conventional fMRI data. The fMRI signal has 2 parts: one describes the correlation between oxidative metabolism (cerebral metabolic rate of oxygen [CMRO 2 ]) and cerebral blood flow (CBF), which supports the bioelectric work to sustain neuronal excitability; the other is the requisite dilation of blood vessels (cerebral blood volume [CBV]), which is the mechanical response involved in removal of waste while providing nutrients. Since changes in energy metabolism are related to bioelectric work, we tested whether spiking frequency of a neuronal ensemble () is reflected by local energy metabolism (CMRO 2 ) in rat brain. We used extracellular recordings to measure ⌬/ and calibrated fMRI (ie, using fMRI signal, CBF, and CBV maps) to measure ⌬CMRO 2 /CMRO 2 during sensory stimulation. We found that ⌬CMRO 2 /CMRO 2 is Ϸ⌬/, which suggests efficient energy use during brain work. Thus, calibrated fMRI provides data on where and by how much the neuronal activity has changed. Possibilities of utilizing calibrated fMRI as a neuroimaging method are discussed.

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Increases in both cerebral glucose utilization and blood flow during execution of a somatosensory task

Cited by 86 publications

References 33 publications

Effect of Side and Rate of Stimulation on Cerebral Blood Flow Changes in Motor Areas during Finger Movements in Humans

Effect of Side and Rate of Stimulation on Cerebral Blood Flow Changes in Motor Areas during Finger Movements in Humans

Transcranial Doppler assessment of cerebral flow velocity during cognitive tasks.

Neuroimaging With Calibrated fMRI

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