Increases in autologous hematopoietic progenitors in the blood of baboons following irradiation and treatment with porcine stem cell factor and interleukin-3

Primitive hematopoietic cell populations reside in the spleen: Studies in the pig, baboon, and human

“…Phenotypic analysis of HPC by flow cytometry. Applying identical procedures for spleen and BM, we stained baboon and human cell suspensions with biotinylated pSCF, FITC-conjugated anti-human CD9 (M-L13 mouse IgG1, BD Biosciences, San Diego, CA, USA), and FITC-CD34 (8G12 mouse IgG1, BD Biosciences), with appropriate controls; pSCF-DNA has 80 to 90% homology with that of other species [28] and cross reacts with human [25] and baboon cells [29].…”

A Review of Advances in Hematopoietic Stem Cell Mobilization and the Potential Role of Notch2 Blockade

“…Cytokines and chemokine Stem cell factor [69][70][71] CXCR4 and VLA-4 FLT3 ligand 72,73 CXCR4 and VLA-4 Thrombopoietin 74 Mpl Angiopoietin 75,76 Angiopoietin Vascular endothelial growth factor 76,77 VEGFR2 IL-1 78 , IL-3 79 , IL-6 80 , IL-7 81 , IL-12 82 , IL-17 83 , and IL-33 84 Various CXCL12 and analogs 85 CXCR4 Gro-a 86 CXCR2 Gro-b 86,87 CXCR2 Gro-g 86 CXCR2 IL-8 88,89 Unknown Chemokine receptor antagonists Inhibitors of the small Rho GTPase Rac1 inhibitors 90 110 Osteopontin Proteasome inhibitors (Bortezomib) 111 CXCL12, angiopoietin, etc. Parathyroid hormone 60 CXCR4 and VLA-4 Blockade of heparan sulfate 112 VLA-4 Stabilization of hypoxia-inducible factor-1a 113 CXCR4 Ephrin A3 receptor antagonists 114 VLA-4 Activation of Nlrp3 inflammasome 115 Nlrp3 Notch2 blockade 116 Notch2 and CXCR4 (CLPs) decreased in anti-DLL4-treated mice, consistent with the role of DLL4 in promoting CLP development in other reports 140 .…”

“…Cytokines and chemokine Stem cell factor [69][70][71] CXCR4 and VLA-4 FLT3 ligand 72,73 CXCR4 and VLA-4 Thrombopoietin 74 Mpl Angiopoietin 75,76 Angiopoietin Vascular endothelial growth factor 76,77 VEGFR2 IL-1 78 , IL-3 79 , IL-6 80 , IL-7 81 , IL-12 82 , IL-17 83 , and IL-33 84 Various CXCL12 and analogs 85 CXCR4 Gro-a 86 CXCR2 Gro-b 86,87 CXCR2 Gro-g 86 CXCR2 IL-8 88,89 Unknown Chemokine receptor antagonists Inhibitors of the small Rho GTPase Rac1 inhibitors 90,91 CXCR4 Bioactive lipids Sphingosine-1 phosphate 92 CXCR4 Ceramide-1 phosphate 92 Unknown Bacterial toxins 93 Lipopolysaccharide 94 CXCR4 Pertussis toxin 95 CXCR4 Proteases Trypsin 96 CXCR4 Matrix metalloprotease 9 97 CXCR4 CD26 98 CXCL12 Cathepsin G 99 CXCR4 Neutrophil elastase 99 CXCR4 Inhibitors of adhesive cell interactions 59 VLA-4 100,101 VLA-4 VLA-4/VLA-9 inhibitors 102 VLA-4 VCAM-1 103 VLA-4 CD44 blockers 104 CD44v10 Polymeric sugar molecules Dextran 105 Likely CXCR4 Fucoidan 106 CXCL12 (SDF-1) Betafectin PGG-glucan 107 Unknown Glycosaminoglycan mimetics 108 CXCL12 (SDF-1) Others Defibroti...…”