Increased α-tocotrienol content in seeds of transgenic rice overexpressing Arabidopsis γ-tocopherol methyltransferase

Zhang, Guiyun; Liu, Ruru; Xu, Geng; Zhang, Peng; Yin, Li; Tang, Kexuan; Liang, Guohua; Liu, Qiaoquan

doi:10.1007/s11248-012-9630-2

Cited by 49 publications

(23 citation statements)

References 46 publications

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“…Mostly, approaches to enhance vitamin E are to increase the activity of the enzymes in each step of the synthesis, including p -hydroxyphenylpyruvate dioxygenase (HPPD; Farre et al, 2012), homogentisate phytyltransferase (HPT1/VTE2; Seo et al, 2011), homogentisate geranylgeranyl transferase (HGGT; Cahoon et al, 2003), homogentisate solanesyltransferase (HST; Sadre et al, 2006), 2-methyl-6-phytyl-benzoquinol methyltransferase (MBPQ-MT/VTE3; Sattler et al, 2004; Tang et al, 2016), tocopherol cyclase (TC/VTE1; Kumar et al, 2005; Yabuta et al, 2013), and γ-tocopherol methyltransferase (γ-TMT/VTE4; Van Eenennaam et al, 2003; Cho et al, 2005; Tavva et al, 2007; Lee et al, 2008; Ghimire et al, 2011; Yabuta et al, 2013; Zhang et al, 2013; Figure 5 ).…”

Section: Manipulation Of Vitamin Metabolismmentioning

confidence: 99%

Manipulation of Metabolic Pathways to Develop Vitamin-Enriched Crops for Human Health

et al. 2017

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Vitamin deficiencies are major forms of micronutrient deficiencies, and are associated with huge economic losses as well as severe physical and intellectual damages to humans. Much evidence has demonstrated that biofortification plays an important role in combating vitamin deficiencies due to its economical and effective delivery of nutrients to populations in need. Biofortification enables food plants to be enriched with vitamins through conventional breeding and/or biotechnology. Here, we focus on the progress in the manipulation of the vitamin metabolism, an essential part of biofortification, by the genetic modification or by the marker-assisted selection to understand mechanisms underlying metabolic improvement in food plants. We also propose to integrate new breeding technologies with metabolic pathway modification to facilitate biofortification in food plants and, thereby, to benefit human health.

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Section: Manipulation Of Vitamin Metabolismmentioning

confidence: 99%

Manipulation of Metabolic Pathways to Develop Vitamin-Enriched Crops for Human Health

et al. 2017

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“…The tocotrienol and tocopherol biosynthesis pathways have a number of similarities (15); they differ only in their first committed step, where geranylgeranyl diphosphate (GGDP) is a precursor in tocotrienol biosynthesis, while phytyl diphosphate (PDP) is a precursor for tocopherol biosynthesis (7,10). Both reactions are believed to occur in the plastids (15).…”

Section: Tocotrienol Biosynthesis Pathwaysmentioning

confidence: 99%

“…Furthermore, the overexpression of HGGT from barley in corn seeds resulted in an approximately six-fold increase in tocochromanols (tocopherols and tocotrienols) (3,4). The overexpression of barley HGGT in maize embryos and seeds of soybean resulted in a six-to ten-fold increase in tocochromanols, specifically tocotrienols (10,17). The increase in tocochromanols was mainly because of the biosynthesis of tocotrienols.…”

Section: Metabolic Engineering For Tocotrienol Production and Increasmentioning

confidence: 99%

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Advances in Genetic Improvement for Tocotrienol Production: A Review

Babura

Abdullah

2017

J Nutr Sci Vitaminol

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Summary Tocotrienols are forms of vitamin E that are present in several important food crops. Compared to tocopherols, less research has been conducted on these compounds because of their low bioavailability and distribution in plant tissues. Both tocotrienols and tocopherols are known for their antioxidant and anticancer activities, which are beneficial for both humans and animals. Moreover, tocotrienols possess certain properties which are not found in tocopherols, such as neuroprotective and cholesterol-lowering activities. The contents of tocotrienols in plants vary. Tocotrienols constitute more than 70% and tocopherols less than 30% of the total vitamin E content in palm oil, which is the best source of vitamin E. Accumulation of tocotrienols also occurs in non-photosynthetic tissues, such as the seeds, fruits and latex of some monocotyledonous and dicotyledonous plant species. The use of biotechnological techniques to increase the tocotrienol content in plants, their biological functions, and benefits to human health are discussed in this review.

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“…A 2.4-fold increase in seed oil tocopherol content was measured as a result of the co-expression of these three transgenes. In addition to oilseed crops, there are also efforts concentrated on engineering the vitamin E content of staple crops (Naqvi et al, 2011;Farre et al, 2012;Zhang et al, 2012). In a recent study that aimed to improve the tocopherol content of maize, a South African elite maize line was transformed with two cDNAs from Arabidopsis that encode enzymes involved in tocopherol biosynthesis (Naqvi et al, 2011).…”

Section: B Vitamin Ementioning

confidence: 99%