Increased Vascular Permeability during Passive Peritoneal Anaphylaxis in the Rat

Ross, Janet W.; Smith, Haller J.; Spicer, Barbara A.

doi:10.1159/000231595

Cited by 29 publications

(26 citation statements)

References 6 publications

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“…Our results correspond to those of previous investi gators who studied rat passive peritoneal anaphylaxis (PPA) under similar conditions [9]. We found that H was released shortly after challenge, and already de clined within 6-20 min.…”

Section: Results and Conclusionsupporting

confidence: 91%

Time Course of Immediate Release and Relationships between Thrombin-Like Proteinase, Other Proteinases, Histamine, Protein and Dye Extravasation in Rat Passive Peritoneal Anaphylaxis

Wilhelms¹,

L²,

Linssen³

1991

Int Arch Allergy Immunol

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A thrombin-like proteinase (THROLP) was detected colorimetrically as the main proteolytic activity (PROA) in the lavage fluid some minutes after antigen challenge of rats for passive peritoneal anaphylaxis (PPA) reaction. THROLP is equivalent to histamine (H) as parameter for the early phase of PPA: both increased significantly after 6 min, but decreased to prechallenge levels 20 min after challenge. H was released from serosal mast cells, in contrast THROLP originates predominantly from plasma leakage and activation of the clotting reaction in PPA. These findings underline the importance of PROA in the sequence of allergic reactions.

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Section: Results and Conclusionsupporting

confidence: 91%

Time Course of Immediate Release and Relationships between Thrombin-Like Proteinase, Other Proteinases, Histamine, Protein and Dye Extravasation in Rat Passive Peritoneal Anaphylaxis

Wilhelms¹,

L²,

Linssen³

1991

Int Arch Allergy Immunol

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“…The maximum BHR is attained within 5 min whereas LHR is much slower. Such an explosive release of mediators has been described in cytotoxic degranulation of human basophils [3] as well as in various experimental models in cluding passively sensitized rat peritoneal mast cells [11] and guinea pig lung [1]. The kinetics of release in blood is consistent with the sudden onset of some systemic ana phylactic reactions which may be encoun tered in clinical practice.…”

Section: Discussionmentioning

confidence: 66%

Allergen-Mediated Histamine Release from Whole Blood

Radermecker¹

1980

Int Arch Allergy Immunol

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An automated spectrofluorometric histamine assay has been applied to the study of allergen-mediated histamine release on small samples of blood. Histamine released into the plasma following incubation of blood with grass pollen, house dust or cat dander was compared in 35 nonallergic controls and 43 atopic patients sensitive to these allergens by history, skin tests and a high RAST score. 14 of the patients suffering from hay fever were examined after completion of at least 1 year of preseasonal immunotherapy. No allergen-mediated histamine release was observed in most nonallergic controls; a negligible release (< 5% of total blood histamine) was seen in about 10% of these subjects. In contrast, a significant histamine release, ranging from 6 to 48% of total blood content, was specifically induced by allergen in over 90% of patients sensitive to it. Negative results are found more frequently in atopic patients submitted to immunotherapy. In some patients, allergen-mediated histamine release on whole blood was compared to that obtained with the corresponding isolated leukocytes. As expected, a good correlation was found between both systems but anaphylactic histamine release occurs much more quickly in the blood than in the leukocyte suspension. This procedure for measuring histamine released by antigen on blood is easy to perform. Heparinized blood may be stored 48 h without modification in the anaphylactic release of histamine and eight different allergens may be tested with 10 ml of blood. It thus appears to be a useful method for exploring reaginic hypersensitivity and may function as an in vitro alternative to skin tests.

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“…1 B could arise from antagonism of the test drugs to anaphylactic mediators. Out of the possible mediators, histamine has been reported to contribute to 60% of the amount of dye leaked in rat PPA (4). Therefore, we investigated the effect of TA-5707 on histamine-induced dye leakage.…”

Section: Resultsmentioning

confidence: 99%

Studies on a new antiallergic pyridinecarboxamide TA-5707F and its sodium salt (TA-5707). II. Mechanism of antiallergic action of TA-5707.

et al. 1987

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Abstract-Mechanism of the antiallergic action of 6-methyl-N-(1 H-tetrazol-5-yl) 2-pyridinecarboxamide (TA-5707F) was studied using the water-soluble sodium salt (TA-5707). 1) TA-5707 administered p.o. at the dose ca. 3 times the ID50 for the PCA reaction did not inhibit capillary dye leakage induced on the rat skin by intracutaneous injection of histamine, serotonin, bradykinin and leukotriene D4 (LTD4). 2) TA-5707, at concentrations above 10-7 M, inhibited antigen-induced histamine release and dye leakage in the rat peritoneal cavity (passive peritoneal anaphylaxis). 3) TA-5707 inhibited both anaphylactic and compound 48/80 induced histamine release from the rat peritoneal mast cells, the IC50 being ca. 10-5 M in both cases. It was concluded that TA-5707F exerts its antiallergic action by inhibiting the release of chemical mediators from sensitized cells.

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Increased Vascular Permeability during Passive Peritoneal Anaphylaxis in the Rat

Cited by 29 publications

References 6 publications

Time Course of Immediate Release and Relationships between Thrombin-Like Proteinase, Other Proteinases, Histamine, Protein and Dye Extravasation in Rat Passive Peritoneal Anaphylaxis

Time Course of Immediate Release and Relationships between Thrombin-Like Proteinase, Other Proteinases, Histamine, Protein and Dye Extravasation in Rat Passive Peritoneal Anaphylaxis

Allergen-Mediated Histamine Release from Whole Blood

Studies on a new antiallergic pyridinecarboxamide TA-5707F and its sodium salt (TA-5707). II. Mechanism of antiallergic action of TA-5707.

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