Increased urinary N-acetyl-β-glucosaminidase (NAG) excretion in young insulin-dependent diabetic patients

Lorini, Renata; Scaramuzza, Andrea; Cortona, L.; Valenti, G; d’Annunzio, Giuseppe; d’Eril, G.V. Melzi

doi:10.1016/0168-8227(95)01117-x

Cited by 10 publications

(10 citation statements)

References 19 publications

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“…Before the onset of gross structural changes in the renal tubules, lysosomal enzymes like NAG have been found to be markedly increased in urine [24]. Several studies elsewhere have shown increased urinary excretion of NAG in diabetics [25–27]. This has been corroborated by our study.…”

Section: Discussionsupporting

confidence: 89%

“…It would appear that sugar control for the majority of our diabetics was suboptimal hence the increased levels of urinary NAG. NAG levels are thought to reflect glycemic control especially in type 1 diabetics [25]. Whether increased levels are transient and related to equally transient hyperglycemia is unclear as we did not measure HBA1c levels since this was not a routine test in our center at the time of this study.…”

Section: Discussionmentioning

confidence: 99%

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Association between Urinary N-Acetyl-Beta-D-Glucosaminidase and Microalbuminuria in Diabetic Black Africans

Udomah

Ekrikpo

Effa

et al. 2012

International Journal of Nephrology

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Diabetes mellitus is the commonest cause of ESRD worldwide and third most common cause in Nigeria. Recent reports from Nigeria indicate the prevalence of diabetic nephropathy as an aetiology of ESRD is increasing necessitating early diagnosis of diabetic nephropathy. We measured the urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG), NAG/creatinine ratio, urinary protein-creatinine ratio and calculated eGFR in 30 recently diagnosed nonhypertensive diabetics and 67 controls. The age and sex distribution, systolic blood pressure, serum and urinary creatinine were similar for both groups. There was higher urinary excretion of NAG (304 versus 184 μmol/h/L, P < 0.001) and NAG/creatinine ratio (21.2 versus 15.7 μmol/h/L/mmolCr, P < 0.001) in the diabetics than controls. There was a strong correlation between NAG/creatinine ratio and albumin/creatinine ratio (r = 0.74, P < 0.001). A multivariate linear regression model showed a significant linear relationship between NAG/creatinine ratio and albumin/creatinine ratio after adjusting for the effect of blood pressure, age, sex, and serum creatinine. The strong association found between albumin/creatinine ratio and NAG/creatinine ratio perhaps indicates the need for further investigation of the clinical utility of NAG/creatinine ratio as a screening tool for early nephropathy in African diabetics.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Association between Urinary N-Acetyl-Beta-D-Glucosaminidase and Microalbuminuria in Diabetic Black Africans

Udomah

Ekrikpo

Effa

et al. 2012

International Journal of Nephrology

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“…During no more than 6 months before the study began, all patients were tested for the presence of retinopathy, nephropathy and peripheral neuropathy, as previously described [19]. Only one patient, a 16-year-old boy, had a background retinopathy, none had an albumin excretion rate > 20 pg/min, while six had subclinical signs of peripheral neuropathy (reduced peroneal motor nerve conduction velocity).…”

Section: E T H 0 D S Subjectsmentioning

confidence: 99%

Cardiovascular Autonomic Testing in Adolescents with Type I (Insulin-Dependent) Diabetes Mellitus: An 18-Month Follow-up Study

et al. 1998

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1. Autonomic abnormalities are frequent in adult patients with diabetes mellitus and progress slowly; little is known about frequency and progression of autonomic abnormalities in childhood. 2. To assess whether autonomic abnormalities are already present in childhood, we evaluated the cardiovascular reflexes, the spectral analysis of spontaneous fluctuations in RR interval and blood pressure (low- and high-frequency), and the baroreflex sensitivity at rest, and after vagal (controlled breathing) and sympathetic activation (tilting) in 25 adolescents with Type I diabetes mellitus, aged 10-17 years, at baseline and after 18 months follow-up, and in 20 age- and sex-matched controls. 3. Cardiovascular reflexes were similar in both patients and controls. Similar significant changes in percentage low- and high-frequency (P < 0.005) from rest to tilting and to control breathing were observed in both patients and controls. The baroreflex sensitivity was also similar in patients and controls. Mild and non-systematic correlations were observed between autonomic tests and disease duration or metabolic control. After 18 months follow-up no changes were observed in any of the measured variables. Correlations with metabolic control remained unchanged. 4. These results indicate a substantial stability of cardiovascular autonomic function in childhood diabetes, and suggest that autonomic abnormalities are likely to develop at an older age.

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“…Therefore, search for early markers of the damage to the kidneys and retina at the first stage of the angiopathy, when the generally acknowledged parameters of the organs function are still within the normal range, is the subject of intensive investigations throughout the world. Several studies draw attention to the disorders of glycoprotein and glycosaminoglican metabolism [involving among others also N-acetyl-beta-D-glucosaminidase (NAG) enzyme] as one of the causes of diabetic retinopathy and nephropathy [5][6][7]. In our previous studies, were carried out on a group of children with newly diagnosed DM type 1 we have shown the significant role of TNFα and NAG and its urine and serum isoforms in the modulation of the inflammatory response in the renal proximal tubules [8].…”

Section: Introductionmentioning

confidence: 99%

The activity of N-acetyl-beta-d-glucosaminidase and tumor necrosis factor-alpha at early stage of diabetic retinopathy development in type 1 diabetes mellitus children

Myśliwiec

Zorena

Balcerska

et al. 2006

Clinical Biochemistry

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Increased urinary N-acetyl-β-glucosaminidase (NAG) excretion in young insulin-dependent diabetic patients

Cited by 10 publications

References 19 publications

Association between Urinary N-Acetyl-Beta-D-Glucosaminidase and Microalbuminuria in Diabetic Black Africans

Association between Urinary N-Acetyl-Beta-D-Glucosaminidase and Microalbuminuria in Diabetic Black Africans

Cardiovascular Autonomic Testing in Adolescents with Type I (Insulin-Dependent) Diabetes Mellitus: An 18-Month Follow-up Study

The activity of N-acetyl-beta-d-glucosaminidase and tumor necrosis factor-alpha at early stage of diabetic retinopathy development in type 1 diabetes mellitus children

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