Increased urinary albumin excretion is associated with a cluster of metabolic alterations in type 2 diabetes mellitus

Inchiostro, S.; Bertoli, G; Zanette, Giorgio; Donada, Carlo; Maccioni, Antonio; Tommasi, Gabriele; Citroni, Nadia; Castagna, Stefano; Donadon, Valter

doi:10.1007/bf00573497

Cited by 2 publications

(2 citation statements)

References 33 publications

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“…Many patients with DM eventually require insulin as β -cell function decreases; therefore, insulin is used more often by patients with longer duration of DM and those with more complications [ 133 , 151 , 152 ]. Yu et al reported a higher risk of HCC in patients with T2DM treated with insulin (RR, 18.5; 95% CI, 2.2–156.0) [ 108 ], and a meta-analysis performed by Singh et al reported a 161% increased risk of HCC in patients treated with insulin [ 121 ].…”

Section: Antidiabetic Medication and Risk Of Hccmentioning

confidence: 99%

Diabetes Mellitus and Risk of Hepatocellular Carcinoma

Wang

Gao

2017

BioMed Research International

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The occurrence of hepatocellular carcinoma (HCC) is two to three times higher in patients with diabetes mellitus (DM), the prevalence of which is increasing sharply worldwide. The purpose of this review was to describe clinical links between DM and HCC and potential biological mechanisms that may account for this association. We evaluated the role of potential pathways that could account for the development of HCC with different etiologies in the presence of DM. In addition, we also briefly discuss the potential effect of other factors such as type and dosage of antidiabetic medicines and duration of DM on HCC risk.

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Section: Antidiabetic Medication and Risk Of Hccmentioning

confidence: 99%

Diabetes Mellitus and Risk of Hepatocellular Carcinoma

Wang

Gao

2017

BioMed Research International

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“…These patients are those often showing the highest insulin blood levels [44] , and this might have contributed to facilitate the development of HCC. It is well known that patients with DM2 treated with insulin are those with more severe hyperinsulinaemia and more complications, including microalbuminuria and ischemic heart disease [45,46] . Our results indicate the need for close surveillance for HCC in patients with chronic liver disease and DM2, particularly when males and treated with insulin.…”

Section: T H E a S S O C I A T I O N O F T Y P E 2 D I A B E T E S W mentioning

confidence: 99%

Association between hepatocellular carcinoma and type 2 diabetes mellitus in Italy: Potential role of insulin

Donadon¹,

Balbi²,

Casarin³

et al. 2008

WJG

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AIM:To investigate the relationships between Type 2 diabetes mellitus (DM2) and the risk of hepatocellular carcinoma (HCC). METHODS:We studied the association between DM2 and HCC in a large case-control study that enrolled 465 consecutive Caucasian patients with HCC (78.3% males, mean age 68.5 ± 8.9 years) compared with an age and sex matched control group of 490 subjects. RESULTS: Prevalence of DM2 was significantly higher in HCC patients (31.2% vs 12.7%; OR = 3.12, 95% CI: 2.22-4.43) and in HCC cases with alcohol abuse. DM2 has been diagnosed before the appearance of HCC in 84.1% of diabetic HCC subjects with mean duration of 141.5 mo, higher in cases treated with insulin than in those with oral antidiabetic agents (171.5 vs 118.7 mo). Compared to controls, males DM2 with HCC were more frequently treated with insulin (38.1% vs 17.6%, P = 0.009) and with sulfonylurea with or without metformin than with diet with or without metformin (84% vs 68.3%, P = 0.049).CONCLUSION: DM2 in our patients is associated with a 3-fold increase risk of HCC. In most of our cases DM2 pre-existed to HCC. Patients with DM2 and chronic liver disease, particularly insulin treated males, should be considered for HCC close surveillance programs.

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Increased urinary albumin excretion is associated with a cluster of metabolic alterations in type 2 diabetes mellitus

Cited by 2 publications

References 33 publications

Diabetes Mellitus and Risk of Hepatocellular Carcinoma

Diabetes Mellitus and Risk of Hepatocellular Carcinoma

Association between hepatocellular carcinoma and type 2 diabetes mellitus in Italy: Potential role of insulin

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