Increased uptake of indium-111 pentetreotide up to 10 years after external thoracic irradiation: report of two cases

Stoffel, M.; Jamar, François; Donckier, Julian; Hainaut, Philippe; Decoster, P.; Beckers, Christian; Pauwels, Stanislas

doi:10.1007/bf00834537

Cited by 15 publications

(3 citation statements)

References 10 publications

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“…Finally, patients with more aggressive forms of MTC develop distant metastases (in the liver, Stoffel et al had done previously. 36 Because none of our patients had been irradiated before, we showed lung, and bone) and/or locally invasive regional recur-/ 7b94$$1495 12-03-97 13:54:18 canxa W: Cancer In-labeled anti-CEA antibody F(ab) 2 fragknown as the lymph node draining stations of thyroid tumors.…”

Section: Discussionmentioning

confidence: 97%

Anti-carcinoembryonic antigen antibodies versus somatostatin analogs in the detection of metastatic medullary thyroid carcinoma

Behr

Gratz

Markus

et al. 1997

Cancer

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Section: Discussionmentioning

confidence: 97%

Anti-carcinoembryonic antigen antibodies versus somatostatin analogs in the detection of metastatic medullary thyroid carcinoma

Behr

Gratz

Markus

et al. 1997

Cancer

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“…Conversely, several tumors had more or less extensive lymphocytic infiltrates and necrotic areas, both of which appeared occasionally sst positive. It is known that lymphoreticular tissue [27,30] and pulmonary fibrosis [43] may express sst. Therefore, a positive octreotide scintigraphy may well be due (at least in part) to radiotracer binding to non-neoplastic cells or tissues (namely, inflammatory or necrotic areas in lung tumors), thus providing information not directly related to the true tumor content of sst.…”

Section: Discussionmentioning

confidence: 99%

Expression of somatostatin receptor types 2, 3 and 5 in biopsies and surgical specimens of human lung tumours

et al. 2001

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The increasingly popular use of somatostatin analogs in clinical practice for both diagnostic and therapeutic purposes prompted extensive investigations on somatostatin receptor (sst) expression in human tumors by autoradiography, nucleic acid analysis and, recently, immunohistochemistry (IHC). The currently employed radiotracer for scintigraphy (Octreoscan) is octreotide, a somatostatin analog having a high affinity for sst types 2, 3, and 5. In this study on 25 patients, we compared sst 2, 3, and 5 expression in surgical and biopsy specimens of lung tumors, as revealed by immunohistochemical and reverse transcriptase polymerase chain reaction (RT-PCR), with the octreoscan outcome (which was positive in 20/25 cases). By IHC, the tumors mainly expressed sst2 (17/25, 68%) at the cell membrane level, while sst 3 and 5 were detected in a fraction of cases (24% and 20%, respectively). Comparing RT-PCR and IHC data, a correlation was found in 83.3% of cases, while octreoscan findings and sst expression were correlated in 22/25 cases (88%). In addition, cytological and biopsy specimens expressed the same sst type found in the corresponding surgical sample, thus indicating that a cell membrane sst immunoreactivity in a biopsy reliably predicts the tumor-receptor profile before its resection. Finally, sst expression was not restricted to neuroendocrine lung tumors, but was also a feature of some non-neuroendocrine carcinomas, although to a lesser extent. The occasional expression of sst subtypes in intratumoral lymphocytes, endothelia and necrotic areas is an additional feature to be considered in the interpretation of Octreoscan findings, since the in vivo procedure does not allow to define the sst cellular distribution. IHC can therefore be usefully coupled to radionuclear investigations to better characterize the sst cellular location and subtype in lung tumors.

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“…Normal physiologic distribution of In-111 octreotide includes faint visualization of thyroid, pituitary gland and marked increased uptake in the liver, spleen, kidneys and bladder. Although rarely encountered, false-positive studies have been reported due to increased activity at nonmalignant pathologies such as Paget’s disease, parathyroid adenoma, cholecystitis, thrombus, abscess, infection, pulmonary fibrosis, pleural plaques and uterine myomas ( 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 ). Only a few cases in the literature have reported increased In-111 octreotide activity in the gallbladder ( 10 , 11 , 12 , 13 , 14 ).…”

Section: Literature Review and Discussionmentioning

confidence: 99%

Visualization of Gallbladder with In-111 Octreotide Scan

Özülker

Özülker²,

Tatoğlu³

et al. 2015

Mirt

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A 54-year-old woman underwent octreotide scintigraphy for evaluation of neuroendocrine tumor recurrence. The images demonstrated unusual uptake in gallbladder area in addition to physiologic uptake at other tissues. Whole-body planar and SPECT imaging were repeated after fatty meal ingestion at 28 hours in order to figure out whether this activity was physiologic or not. Since the unusual uptake in the gallbladder was still detected at these images, additional images were obtained 72 hours after radionuclide injection. The activity in the gallbladder disappeared at these images revealing the physiologic nature of this unusual accumulation.

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Increased uptake of indium-111 pentetreotide up to 10 years after external thoracic irradiation: report of two cases

Cited by 15 publications

References 10 publications

Anti-carcinoembryonic antigen antibodies versus somatostatin analogs in the detection of metastatic medullary thyroid carcinoma

Anti-carcinoembryonic antigen antibodies versus somatostatin analogs in the detection of metastatic medullary thyroid carcinoma

Expression of somatostatin receptor types 2, 3 and 5 in biopsies and surgical specimens of human lung tumours

Visualization of Gallbladder with In-111 Octreotide Scan

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