Increased uptake and improved outcomes of bowel cancer screening with a faecal immunochemical test: results from a pilot study within the national screening programme in England

Moss, Sue; Mathews, Christopher; Day, Teresa; Smith, Steve; Seaman, Helen E.; Snowball, Julia; Halloran, Stephen P

doi:10.1136/gutjnl-2015-310691

Cited by 166 publications

(174 citation statements)

References 35 publications

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“…For instance, in a randomised controlled trial conducted in Spain, the PRs of colonoscopy group and faecal immunochemical test group were 34.2% and 24.6%, respectively (p<0.001) 17. A recent study from England reported that the PR using FOBT even increased to 66.4% in the National Health Service Bowel Cancer Screening Programme 16. Our analyses showed that previous FOBT was associated with increased uptake of subsequent colonoscopy.…”

Section: Discussionsupporting

confidence: 42%

Participation and yield of a population-based colorectal cancer screening programme in China

Chen

Ren

et al. 2018

Gut

233

237

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ObjectiveColorectal cancer (CRC) screening has been widely implemented in many countries. However, evidence on participation and diagnostic yield of population-based CRC screening in China is sparse.DesignThe analyses were conducted in the context of the Cancer Screening Program in Urban China, which recruited 1 381 561 eligible participants aged 40–69 years from 16 provinces in China from 2012 to 2015. 182 927 participants were evaluated to be high risk for CRC by an established risk score system and were subsequently recommended for colonoscopy. Participation rates and detection of colorectal neoplasms in this programme were reported and their associated factors were explored.Results25 593 participants undertook colonoscopy as recommended, with participation rate of 14.0%. High level of education, history of faecal occult blood test, family history of CRC and history of colonic polyp were found to be associated with the participation in colonoscopy screening. Overall, 65 CRC (0.25%), 785 advanced adenomas (3.07%), 2091 non-advanced adenomas (8.17%) and 1107 hyperplastic polyps (4.33%) were detected. Detection rates of colorectal neoplasms increased with age and were higher for men. More advanced neoplasms were diagnosed in the distal colon/rectum (65.2%). Several factors including age, sex, family history of CRC, dietary intake of processed meat and smoking were identified to be associated with the presence of colorectal neoplasms.ConclusionThe diagnostic yield was not optimal using colonoscopy screening in high-risk populations given the relatively low participation rate. Our findings will provide important references for designing effective population-based CRC screening strategies in the future.

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Section: Discussionsupporting

confidence: 42%

Participation and yield of a population-based colorectal cancer screening programme in China

Chen

Ren

et al. 2018

Gut

233

237

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“…However, it has the disadvantages of a bowel preparation requirement and a risk for bowel rupture, and this method is not suitable for patients with anorectal stenosis, peritoneal irritation, severe cardiopulmonary function and other diseases . The faecal immunochemical test (FIT) is replacing the guaiac faecal occult blood test (gFOBT) in CRC screening . However, the diagnostic performance of the FIT depends on the cutoff value for a positive result .…”

Section: Introductionmentioning

confidence: 99%

“…2 The faecal immunochemical test (FIT) is replacing the guaiac faecal occult blood test (gFOBT) in CRC screening. [3][4][5] However, the diagnostic performance of the FIT depends on the cutoff value for a positive result. 6 Amitay et al 7 studied factors associated with falsepositive FIT results, including male sex, older age, obesity, smoking, aspirin use and newly detected nonneoplastic bowel disease.…”

Section: Introductionmentioning

confidence: 99%

Circulating lncRNA SNHG11 as a novel biomarker for early diagnosis and prognosis of colorectal cancer

Zhou

Wang

et al. 2019

Intl Journal of Cancer

140

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Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer mortality worldwide. Emerging evidence indicates that tumour cells release substantial amounts of RNA into the bloodstream, in which RNA strongly resists RNases and is present at sufficient levels for quantitative analyses. Our study aimed to discover blood‐based markers for the early detection of CRC and to ascertain their efficiency in discriminating healthy controls, patients with polyps and adenomas and cancer patients. We first analysed and screened ZFAS1, SNHG11, LINC00909 and LINC00654 in a bioinformatics database and then collected clinical plasma samples for preliminary small‐scale analysis and further large‐scale verification. We then explored the mechanism of dominant lncRNA SNHG11 expression in CRC by in vitro and in vivo assays. The combination of ZFAS1, SNHG11, LINC00909 and LINC00654 showed high diagnostic performance for CRC (AUC: 0.937), especially early‐stage disease (AUC: 0.935). Plasma levels of the four candidate lncRNAs were significantly reduced in postoperative samples compared to preoperative samples. A panel including these four lncRNAs performed well in distinguishing patient groups with different stages of colon disease, and SNHG11 exhibited the greatest diagnostic ability to identify precancerous lesions and early‐stage tumour formation. Mechanistically, high SNHG11 expression promotes proliferation and metastasis by targeting the Hippo pathway. Taken together, the data indicate that SNHG11 may be a novel therapeutic target for the treatment of CRC and a potential biomarker for the early detection of CRC.

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“…We read with interest the results of the pilot study in England, which was performed to establish the acceptability and diagnostic performance of screening with the faecal immunochemical test (FIT) over the guaiac faecal occult blood test (gFOBT) 1. When comparing gFOBT to FIT, the uptake increased from 59.4% to 66.4%, positivity rate increased from 1.7% to 7.8% (at a cut-off level of 20 µg Hb/g faeces) and colorectal cancer (CRC) detection doubled.…”

mentioning

confidence: 99%

Stage distribution of screen-detected colorectal cancers in the Netherlands

Toes‐Zoutendijk

Kooyker

Elferink

et al. 2017

Gut

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Increased uptake and improved outcomes of bowel cancer screening with a faecal immunochemical test: results from a pilot study within the national screening programme in England

Cited by 166 publications

References 35 publications

Participation and yield of a population-based colorectal cancer screening programme in China

Participation and yield of a population-based colorectal cancer screening programme in China

Circulating lncRNA SNHG11 as a novel biomarker for early diagnosis and prognosis of colorectal cancer

Stage distribution of screen-detected colorectal cancers in the Netherlands

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