Increased trunk fat is associated with altered gene expression in breast tissue of normal weight women

Cho, Byuri Angela; Iyengar, Neil M.; Zhou, Xi Kathy; Mendieta, Hillary; Winston, Lisle; Falcone, Domenick J.; Landa, Jonathan; Morrow, Monica; Dannenberg, Andrew J.

doi:10.1038/s41523-021-00369-8

Cited by 3 publications

(8 citation statements)

References 39 publications

(67 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Adipokines and chronic inflammatory factors have also been implicated in obesity. Trunk fat and android fat were inversely correlated with adiponectin ( 40 , 41 ), whereas correlated with increased leptin ( 42 , 43 ). The leg fat was positively correlated with adiponectin ( 44 ).…”

Section: Discussionmentioning

confidence: 98%

Regional Fat Distributions Are Associated With Subclinical Right Ventricular Dysfunction in Adults With Uncomplicated Obesity

Liu

et al. 2022

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

ObjectiveObesity is a prominent public health problem that has increased cardiovascular mortality risks. However, the specific effects of obesity, independent of comorbidities, on cardiac structure and function have not been well clarified, especially those effects on the right ventricle (RV). Cardiovascular magnetic resonance (CMR) tissue tracking can assess detailed RV mechanical features. This study aimed to evaluate RV strain using CMR in uncomplicated obese adults and assess its association with fat distributions.MethodsA total of 49 obese patients and 30 healthy controls were included. The RV global systolic function and strain parameters based on CMR were assessed. Body fat distributions were measured with dual X-ray absorptiometry. RV function indices of obese patients were compared with those of healthy controls. Correlations among related body fat distribution parameters and RV function indices were conducted with multivariable linear regression.ResultsCompared with healthy controls, the obese group had impaired RV strain with lower global longitudinal peak strain (PS), longitudinal peak systolic strain rate (PSSR), circumferential and longitudinal peak diastolic strain rates (PDSR) (all P < 0.05), while LV and RV ejection fractions were not significantly different between the two groups (P > 0.05). Multivariable linear regression analysis demonstrated that android fat% was independently associated with longitudinal PS (β = −0.468, model R2 = 0.219), longitudinal PDSR (β = −0.487, model R2 = 0.237), and circumferential PSSR (β = −0.293, model R2 = 0.086). Trunk fat% was independently associated with longitudinal PSSR (β = −0.457, model R2 = 0.209). In addition, the strongest correlations of circumferential PDSR were BMI and gynoid fat% (β = −0.278, β = 0.369, model R2 = 0.324).ConclusionsExtensive subclinical RV dysfunction is found in uncomplicated obese adults. BMI, as an index of overall obesity, is independently associated with subclinical RV dysfunction. In addition, central obesity (android fat and trunk fat distributions) has a negative effect on subclinical RV function, while peripheral obesity (gynoid fat distribution) may have a positive effect on it.Clinical Trials RegistrationEffect of lifestyle intervention on metabolism of obese patients based on smart phone software (ChiCTR1900026476).

show abstract

Section: Discussionmentioning

confidence: 98%

Regional Fat Distributions Are Associated With Subclinical Right Ventricular Dysfunction in Adults With Uncomplicated Obesity

Liu

et al. 2022

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

show abstract

“…VEGF and leptin serum levels are also dependent on IL6 gene polymorphism in children with obesity: higher values of VEGF level were found in case of the IL6 572 gene CC and GG genotypes, whereas leptin levels depended on IL6 174 and IL6 572 gene polymorphisms 105 . Elevated levels of trunk adiposity are associated with high leptin gene expression and elevated VEGF C level in WAT from breast, even in subjects without obesity 106 . In subjects with obesity, the number of mitochondrial deoxyribonucleic acid mtDNA in mononuclear blood cells has been found to correlate with leptin blood level, which also correlates with the concentration of the circulating adhesion molecule VCAM‐1.…”

Section: Resultsmentioning

confidence: 96%

“…[112][113][114][115] Studies of patients with obesity have confirmed the genetic or epigenetic aspect of leptin-VEGF crosstalk, pointing to the role of obesity-dependent leptin gene regulation. [104][105][106][107] These studies have also revealed that leptin-VEGF crosstalk is a complicated network, involving leptin canonical and noncanonical signaling pathways, HIF-1A, and NfkB as the core, 97,124,136 with a range of substances (including adiponectin, visfatin, ghrelin, IL-6, insulin, cholesterol, LDL, triglycerides, ApoB, trimethylamine N-oxide, and NO) acting as accompanying, modifying, and disrupting factors. [99][100][101] In female patients with excess body mass and related disorders, leptin-VEGF crosstalk may be involved in PCOS, adverse pregnancy outcome, 129 and preeclampsia.…”

Section: Discussionmentioning

confidence: 99%

“…99 level in WAT from breast, even in subjects without obesity. 106 In subjects with obesity, the number of mitochondrial deoxyribonucleic acid mtDNA in mononuclear blood cells has been found to correlate with leptin blood level, which also correlates with the concentration of the circulating adhesion molecule VCAM-1. No such relation was found for VEGF.…”

Section: Human Studiesmentioning

confidence: 99%

“…105 Elevated trunk obesity is associated with increased leptin gene expression and VEGFC level in WAT. 106 The quantity of mtDNA in mononuclear blood cells is associated with the blood level of leptin but not of VEGF. 107 This narrow range of studies confirms the genetic or epigenetic basis of leptin-VEGF crosstalk, while nonetheless putting the greater emphasis for leptin gene regulation on obesity.…”

Section: Human Studiesmentioning

confidence: 99%

See 2 more Smart Citations

Leptin–VEGF crosstalk in excess body mass and related disorders: A systematic review

Skrypnik

Suliburska

et al. 2023

Obesity Reviews

View full text Add to dashboard Cite

Summary By 2030, it is expected that a billion people will have suffer from obesity. Adipose tissue synthesizes leptin, an adipokine that affects cardiovascular risk. Leptin intensifies the synthesis of vascular endothelial growth factor (VEGF). Our study reviews recent reports on leptin–VEGF crosstalk in obesity and related disorders. PubMed, Web of Science, Scopus, and Google Scholar were searched. One hundred and one articles involving human, animal, and in vitro research were included. In vitro studies show the crucial role of interaction between endothelial cells and adipocytes and hypoxia as a factor that intensifies leptin's effects on VEGF. Leptin–VEGF crosstalk promotes the progression of cancer. The animal research reveal that a high‐fat diet enhances leptin and VEGF crosstalk. Genetic and epigenetic mechanisms and procreator‐offspring programming may be involved in leptin–VEGF crosstalk. Some female‐specific characteristics of leptin–VEGF relation in obesity were observed. The human studies have shown that increased leptin and VEGF synthesis and leptin–VEGF crosstalk are factors linking obesity with elevated cardiovascular risk. The studies of the last 10 years documented a range of significant aspects of leptin–VEGF crosstalk specific for obesity and related disorders, shedding new light on the link between obesity and increased cardiovascular risk.

show abstract

Translating energy balance research from the bench to the clinic to the community: Parallel animal‐human studies in cancer

Garcia

Schadler

Chandra

et al. 2023

CA A Cancer J Clinicians

View full text Add to dashboard Cite

Advances in energy balance and cancer research to date have largely occurred in siloed work in rodents or patients. However, substantial benefit can be derived from parallel studies in which animal models inform the design of clinical and population studies or in which clinical observations become the basis for animal studies. The conference Translating Energy Balance from Bench to Communities: Application of Parallel Animal‐Human Studies in Cancer, held in July 2021, convened investigators from basic, translational/clinical, and population science research to share knowledge, examples of successful parallel studies, and strong research to move the field of energy balance and cancer toward practice changes. This review summarizes key topics discussed to advance research on the role of energy balance, including physical activity, body composition, and dietary intake, on cancer development, cancer outcomes, and healthy survivorship.

show abstract

Increased trunk fat is associated with altered gene expression in breast tissue of normal weight women

Cited by 3 publications

References 39 publications

Regional Fat Distributions Are Associated With Subclinical Right Ventricular Dysfunction in Adults With Uncomplicated Obesity

Regional Fat Distributions Are Associated With Subclinical Right Ventricular Dysfunction in Adults With Uncomplicated Obesity

Leptin–VEGF crosstalk in excess body mass and related disorders: A systematic review

Translating energy balance research from the bench to the clinic to the community: Parallel animal‐human studies in cancer

Contact Info

Product

Resources

About