Increased Transcutaneous Oxygen Tension in the Skin Dorsum Over the Foot in Patients With Diabetic Foot Disease in Response to the Topical Use of an Emulsion of Hyperoxygenated Fatty Acids

Abstract

The aim of this study was to examine changes in the skin over the feet of patients with diabetic foot syndrome after local application of a product containing hyperoxygenated fatty acids (HOFAs) by measuring transcutaneous oxygen. In 64 patients, transcutaneous oxygen pressure (TcPo(2)) was measured on days 0, 7, 30, 60, and 90 of the study. Foot skin dryness, shedding, and skin color were also assessed using a clinical score. The patients were grouped on the basis of initial levels of transcutaneous oxygen; group 1 comprised patients with TcPo( 2) >30 mm Hg and group 2 comprised patients with TcPo(2) <30 mm Hg on the skin over the dorsum of the feet. Increases in local oxygenation values were observed at a local level in group 2 patients after 30 days of treatment. Skin trophism showed clinical improvement in all patients and these observations may be attributed to improved local microcirculation.

Detection of fiber effects on skin health of the human foot

“…The number of participants ( n = 16), sex (all male), and age range (25–75 years) were similar to those in other sock/skin health studies. 12,16,41,42 Although participants met similar criteria regarding health and activity and were predominantly of similar ethnicity, as expected, measurements of all parameters varied among them. Some of this variability seems to have been associated with differences in physical form of the feet (bony, plump).…”

Increasing Transcutaneous Oxygen Pressure in Patients With Neuroischemic Diabetic Foot Ulcers Treated With a Sucrose Octasulfate Dressing: A Pilot Study

“…Patients were placed on the supine position during the 10 minutes examination and were asked not to move or speak. 26 After calibrating, the electrode was placed at dorsalis pedis artery in all DFUs located at toes or forefoot and at posterior tibial artery in those patients who had DFUs at midfoot or rearfoot. 27 TcPO 2 values were assessed at day 0, on a monthly basis and the day of wound closure occurrence.…”

Utilización de un compuesto de ácidos grasos hiperoxigenados en el tratamiento de heridas crónicas superficiales de diferentes etiologías

“…Existen en el mercado diferentes compuestos de AGHO con diferencias en cuanto a su composición y proceso de fabricación, lo que define perfiles diferentes de acción que en ningún momento pueden extrapolarse de un producto a otro. Mepentol® y Mepentol® Leche (Alfasigma) tienen numerosas evidencias científicas experimentales [17][18][19][20][21][22][23][24][25] así como una extensa experiencia clínica [25][26][27][28][29][30][31][32][33][34][35] que avala su uso en el mantenimiento de la piel en condiciones fisiológicas óptimas: mejoran la microcirculación sanguínea, de forma rápida y prolongada, evitando la isquemia del tejido cutáneo; favorecen la renovación de las células epidérmicas, mejorando la resistencia de la piel; y aportan un grado óptimo de hidratación, evitando la sequedad cutánea y restaurando el film hidrolipídico. Estas actividades proporcionan una excelente prevención primaria, mejorando el estado de la piel para que no aparezcan futuras lesiones.…”