Increased Toxicity of Na3Ca DTP When Given by Protracted Administration

A Toxicological Study of the Pentasodium Salt of Puchel Using CBA Mice

“…Reuber (1967) reported hydropic degeneration in the liver after treatment with DTPA. Taylor et al (1974) found that dogs receiving daily doses of 5.8 >mol kg-1 of CaNa3DTPA showed lesions in the large and small intestine consisting of haemorrhage, degeneration of villi and some loss of the epithelial lining of the crypts and villi. Haemorrhages were also seen in the kidney, consisting of foci of interstitial haemorrhage, swelling of the epithelium in the proximal tubules and some hyaline cast formation.…”

“…Toxicological studies on DTPA are well established (Catsch, 1964;Morgan & Smith, 1974a;1974b;Taylor et al , 1974;Volf, 1978;Weber, 1969). After a preliminary LD50 study (Smith & Bulman, 1981) some toxic effects were reported following both injection and inhalation of Puchel (Stather et al, 1982).…”

The enhancement of vascular permeability by DTPA.

“…BALLOU and PALOTAY reported the absorbed sites of DTPA in the rat administered orally were the jejunum and ileum.16) We observed the vasodilation, exudation of the blood and deposition of hemosiderin outside the vessels in the lamina propria of the small intestine of rats and beagle dogs administered orally.7,8) The intestinal disturbances and its related clinical signs, i.g., loss of appetite, diarrhea, vomiting, melena were observed regardless of administration routes of DTPA, although those causes had been obscure. 10,11,17) It is likely that the gastro-intestinal tract is more sensitive to DTPA. SPENCER and ROSOFF observed thedecr ease of blood pressure with bradycardia continued 2-4hr after DTPA intravenous injection in the patient.9) This finding is corresponding to our results in which the increase of vascular permeability changes continued for 5 hr after the intradermal injection of DTPA.…”

Effect of intravenously injected DTPA on cardiovascular system in rats.

“…We have been studying on the side effects of DTPA (diethylenetriaminepentaacetic acid) which is a chelating agent to decorporate the actinides from humans.1-3 Because the toxicological studies have not efficiently been carried out to judge correctly the use of DTPA for humans. [4][5][6][7][8] The most effectiveness of decorporation of DTPA is expectable in the case that DTPA is injected intravenously before the actinides deposite in the critical organs.9 The summarized results in the previous reports indicated that DTPA induced the untoward effects on the vascular system in animals.4,s,io In our previous study, it was demonstrated that DTPA enhanced the vascular permeability and we considered that this action was one of reasons why DTPA induced the vasodiation, hemorrhage and congestion invarious organs.3 However, the acute effects with the intravenous injection of DTPA have not been investigated, especially on the cardiovascular system.…”