Increased thymus weight in sudden infant death syndrome compared to controls: The role of sub‐clinical infections

Goldwater, Paul N.; Kelmanson, Igor A.; Little, Bertis B.

doi:10.1002/ajhb.23528

Cited by 10 publications

(12 citation statements)

References 55 publications

(82 reference statements)

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“…Major difference was observed among thymus and brain weights and sizes. Heavier thymus points out to a possible infectious link to SIDS demises and larger brain sizes and weights shows a possible neuropathological roles (151). Larger thymus highlights the possible involvement of immunological genes which may be explored in this context.…”

Section: Discussionmentioning

confidence: 97%

Comprehensive Analysis of Genes Associated With Sudden Infant Death Syndrome

Mehboob

Kurdi

Ahmad³

et al. 2021

Front. Pediatr.

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Background: Sudden infant death syndrome (SIDS) is a tragic incident which remains a mystery even after post-mortem investigation and thorough researches.Methods: This comprehensive review is based on the genes reported in the molecular autopsy studies conducted on SIDS so far. A total of 20 original studies and 7 case reports were identified and included in this analysis. The genes identified in children or adults were not included. Most of the genes reported in these studies belonged to cardiac channel and cardiomyopathy. Cardiac channel genes in SIDS were scrutinized for further analysis.Results: After screening and removing the duplicates, 42 unique genes were extracted. When the location of these genes was assessed, it was observed that most of these belonged to Chromosomes 11, 1 and 3 in sequential manner. The pathway analysis shows that these genes are involved in the regulation of heart rate, action potential, cardiac muscle cell contraction and heart contraction. The protein-protein interaction network was also very big and highly interactive. SCN5A, CAV3, ALG10B, AKAP9 and many more were mainly found in these cases and were regulated by many transcription factors such as MYOG C2C1 and CBX3 HCT11. Micro RNA, “hsa-miR-133a-3p” was found to be prevalent in the targeted genes.Conclusions: Molecular and computational approaches are a step forward toward exploration of these sad demises. It is so far a new arena but seems promising to dig out the genetic cause of SIDS in the years to come.

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Section: Discussionmentioning

confidence: 97%

Comprehensive Analysis of Genes Associated With Sudden Infant Death Syndrome

Mehboob

Kurdi

Ahmad³

et al. 2021

Front. Pediatr.

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“…The pathological findings [4] include the following: heavy fluid-laden lungs with early subtle acute inflammatory changes; intrathoracic petechial hemorrhages in and on the thymus, epicardium, and visceral pleura/lungs; liquid blood in the chambers of the heart; heavier than normal thymus [5,6], brain [5,[7][8][9][10][11][12][13][14], and liver [5,14,15]; empty bladder; and raised core temperature [16].…”

Section: Introductionmentioning

confidence: 99%

Infection, Celestial Influences, and Sudden Infant Death Syndrome: A New Paradigm

Goldwater¹,

Oberg²

2021

Cureus

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The etiology of sudden infant death syndrome (SIDS) still remains unclear. This situation would seem unprecedented for 21st-century medical science. This article explores scientific fields that have not been largely considered in investigating the etiology of SIDS so far. In this study, we examined previously ignored studies on heliobiology, celestial influences, and SIDS in the non-medical literature in an attempt to answer the following questions: is there a relationship between sunspot/solar activity and the occurrence of SIDS? Could there be alternative reasons for the decline in SIDS incidences in the 1990s that were originally attributed to the "Back-to-Sleep" campaign? We note that the decline coincided with the ~11-year cyclical diminution in sunspot numbers (SSNs). The SSN/SIDS relationship does not necessarily imply causality; however, it supports published data regarding sunspots, Schumann resonance, and geomagnetic effects. How solar energy could adversely influence a baby's existence remains conjectural. Observations in this respect suggest pathways involving melatonin and/or infection/inflammation.

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“…In case of infants, is even more difficult based on the lack of the subjective response from the patient. Given that, early screening might prevent this sudden infant death syndrome in certain cases (De Visme et al, 2020;Merino et al, 2020) and even decrease the number of such occurrences (Goldwater et al, 2020).…”

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confidence: 99%

Medical, Forensic and Social Quandaries of Sudden Infant Death Syndrome Today

Iov¹,

Furnica

David

et al. 2020

BRAIN

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Sudden Infant Death Syndrome (SIDS) is described as the sudden, unexplained death (with no attributable cause, during sleep) of a seemingly healthy child before reaching the first year of life. Statistically, SIDS is recognized today as a leading cause of death in infants aged 1 to 12 months. In the present article the authors have analyzed known risk factors, classifications and current standards of forensic investigation while highlighting the necessity of detailed clinical history, autopsy, scene of death examination and lab findings (radiology, metabolic anomalies, infectious diseases and toxicology) in SIDS diagnosis. For an infant death to be considered SIDS, all other possible causes of death must be first excluded, the diagnosis requiring detailed collection and analysis of antemortem patient data and a complete autopsy. Although the forensic methods of today are more exact, the distinction between SIDS and other causes of death (e.g. unintentional asphyxiation, infanticide) remains very difficult in some cases.

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Increased thymus weight in sudden infant death syndrome compared to controls: The role of sub‐clinical infections

Cited by 10 publications

References 55 publications

Comprehensive Analysis of Genes Associated With Sudden Infant Death Syndrome

Comprehensive Analysis of Genes Associated With Sudden Infant Death Syndrome

Infection, Celestial Influences, and Sudden Infant Death Syndrome: A New Paradigm

Medical, Forensic and Social Quandaries of Sudden Infant Death Syndrome Today

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