Increased Thrombopoiesis and Platelet Activation in Hantavirus-Infected Patients

Connolly‐Andersen, Anne‐Marie; Sundberg, Erik; Ahlm, Clas; Hultdin, Johan; Baudin, Maria; Larsson, Jan; Dunne, Eimear; Kenny, Dermot; Lindahl, Tomas; Ramström, Sofia; Nilsson, Sofie

doi:10.1093/infdis/jiv161

Cited by 54 publications

(56 citation statements)

References 37 publications

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“…Kato et al showed that decreased APN levels contribute to enhanced thrombus formation and platelet aggregation [33]. Connolly-Andersen et al observed increased thrombopoiesis and platelet activation contributing to intravascular coagulation and thrombocytopoenia [5]. Our study showed that both total and HMW APN levels in the plasma positively correlate with PLT counts.…”

Section: Discussionsupporting

confidence: 59%

“…Enhanced EC permeability leads to the dysfunction of the EC barrier, manifested as petechia, oedema, and hypotension, which may underlie the pathogenesis of HFRS [4]. Increased thrombopoiesis and platelet activation may induce intravascular coagulation and cause thrombocytopenia, the accumulation of inflammatory cells, and the release of proinflammatory cytokines in kidney tissue contributing to renal damage [4, 5]. …”

Section: Introductionmentioning

confidence: 99%

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Sustained High Levels of Both Total and High Molecular Weight Adiponectin in Plasma during the Convalescent Phase of Haemorrhagic Fever with Renal Syndrome Are Associated with Disease Severity

Kang

Zhang

et al. 2017

Journal of Immunology Research

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Haemorrhagic fever with renal syndrome (HFRS) is characterised by an uncontrolled immune response that causes vascular leakage. Adiponectin (APN) is an adipocytokine involved in prorevascularisation and immunomodulation. To investigate the possible effects of APN in the pathogenesis of HFRS, total and high molecular weight (HMW) APN levels in the plasma of patients with HFRS were quantified using enzyme-linked immunosorbent assay (ELISA). Compared with those in healthy controls, the plasma total and HMW APN levels in patients were elevated to different degrees from the fever onset and remained high at the convalescent phase. Consistent with these results, western blot analysis additionally showed that low molecular weight (LMW), middle molecular weight (MMW), and HMW APN levels were all elevated and contributed to the elevation of the total APN level. Importantly, sustained high levels of total and HMW APN at the convalescent phase were significantly higher in patients with critical disease than those in patients with mild or moderate disease. Moreover, total and HMW APN levels negatively correlated with white blood cell count and positively correlated with platelet count and serum albumin level. These results may provide insights into understanding the roles of total and HMW APN in the pathogenesis of HFRS.

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Section: Discussionsupporting

confidence: 59%

Section: Introductionmentioning

confidence: 99%

Sustained High Levels of Both Total and High Molecular Weight Adiponectin in Plasma during the Convalescent Phase of Haemorrhagic Fever with Renal Syndrome Are Associated with Disease Severity

Kang

Zhang

et al. 2017

Journal of Immunology Research

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“…[2] The cause of thrombocytopenia seems not to be impaired platelet production, as enhanced thrombopoiesis and activated platelets have been observed in PUUV-infected patients. [27,32] Neither seems enhanced clearance or pooling of platelets in the enlarged spleen to be involved, as indicated by a previously recorded lack of association of thrombocytopenia and spleen size in PUUV induced HFRS. [33] Endothelial activation markers associate with thrombocytopenia [34] and pathogenic hantaviruses are known to direct the adherence of quiescent platelets through b3-integrin to the surface of infected endothelial cells [35] and specifically to PUUV particles.…”

Section: Discussionmentioning

confidence: 99%

Thrombocytopenia associates with the severity of inflammation and variables reflecting capillary leakage in Puumala Hantavirus infection, an analysis of 546 Finnish patients

Outinen

Laine

Mäkelä

et al. 2016

Infectious Diseases

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“…Despite these variable clinical pictures [13,14], which depend on the hantavirus and its geographic origin, HFRS and HCPS share common characteristics. In particular, thrombocytopenia [15,16] and vascular leakage [17,18] correlate with disease severity. These features have been compared to the different forms of dengue presenting similar clinical manifestations [19].…”

Section: Introductionmentioning

confidence: 99%

What Do We Know about How Hantaviruses Interact with Their Different Hosts?

Ermonval

Baychelier

Tordo

2016

Viruses

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Hantaviruses, like other members of the Bunyaviridae family, are emerging viruses that are able to cause hemorrhagic fevers. Occasional transmission to humans is due to inhalation of contaminated aerosolized excreta from infected rodents. Hantaviruses are asymptomatic in their rodent or insectivore natural hosts with which they have co-evolved for millions of years. In contrast, hantaviruses cause different pathologies in humans with varying mortality rates, depending on the hantavirus species and its geographic origin. Cases of hemorrhagic fever with renal syndrome (HFRS) have been reported in Europe and Asia, while hantavirus cardiopulmonary syndromes (HCPS) are observed in the Americas. In some cases, diseases caused by Old World hantaviruses exhibit HCPS-like symptoms. Although the etiologic agents of HFRS were identified in the early 1980s, the way hantaviruses interact with their different hosts still remains elusive. What are the entry receptors? How do hantaviruses propagate in the organism and how do they cope with the immune system? This review summarizes recent data documenting interactions established by pathogenic and nonpathogenic hantaviruses with their natural or human hosts that could highlight their different outcomes.

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Increased Thrombopoiesis and Platelet Activation in Hantavirus-Infected Patients

Abstract: HFRS patients have increased thrombopoiesis and platelet activation, which contributes to intravascular coagulation.

Cited by 54 publications

References 37 publications

Sustained High Levels of Both Total and High Molecular Weight Adiponectin in Plasma during the Convalescent Phase of Haemorrhagic Fever with Renal Syndrome Are Associated with Disease Severity

Sustained High Levels of Both Total and High Molecular Weight Adiponectin in Plasma during the Convalescent Phase of Haemorrhagic Fever with Renal Syndrome Are Associated with Disease Severity

Thrombocytopenia associates with the severity of inflammation and variables reflecting capillary leakage in Puumala Hantavirus infection, an analysis of 546 Finnish patients

What Do We Know about How Hantaviruses Interact with Their Different Hosts?

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