Increased thrombin generation in kidney transplant recipients with donor-specific antibodies directed against human leukocyte antigens
Linda Lóczi,
Réka P. Szabó,
Rita Orbán-Kálmándi
et al.
Abstract:IntroductionThe development of de novo anti-HLA donor specific antibodies (DSAs) is associated with poor outcomes in kidney transplant recipients. It is surmised that an interaction between DSAs and the graft endothelium cause tissue injury, however, the exact underlying pathomechanism and optimal management of patients with DSAs remain undetermined.AimsWe hypothesized that in kidney transplant recipients the presence of DSAs induce hemostasis alterations, including hypercoagulability, as assessed by the throm… Show more
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