Increased the TMZ concentration in brain by poly(2-ethyl-2-oxazoline) conjugated temozolomide prodrug micelles for glioblastoma treatment

Xu, Kang; Long, Zhang; Gu, Yuqi; Yang, Huasha; Du, Bin; Liu, Hongmei; Li, Yuling

doi:10.1016/j.eurpolymj.2020.110232

Cited by 13 publications

(4 citation statements)

References 54 publications

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“…[108] An interesting concept was reported by Liu, Li and coworkers who demonstrated that PEtOx end-functionalized with temozolomide self-assembled into micellar drug carriers, thereby enhancing the blood circulation time and increasing the accumulation in and inhibition of glioblastoma. [109] Ashjari reported a poly(2-oxazoline)-based block copolymer drug conjugate consisting of a hydrophilic PEG block and a thermoresponsive PiPrOx block having doxorubicin conjugated through pHdegradable hydrazine linkers to the poly(2-oxazoline) chain end. [110] This provides a dualresponsive micellar drug delivery vehicle for which it was demonstrated that most efficient drug release occurred at slightly elevated temperature and a low pH of 5, as is the case in a tumor microenvironment.…”

Section: Emerging Trends In the Properties And Applications Of Poly(2...mentioning

confidence: 99%

The future of poly(2-oxazoline)s

Hoogenboom¹

2022

European Polymer Journal

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Section: Emerging Trends In the Properties And Applications Of Poly(2...mentioning

confidence: 99%

The future of poly(2-oxazoline)s

Hoogenboom¹

2022

European Polymer Journal

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“…In the past few decades, micro-/nano-particles have received significant attentions in biomedical fields, especially in drug delivery, and achieved promising results in animal experiments. − However, there is still an enormous challenge in clinical application . One of the main reasons is that the inappropriate size and shape of particles impede their entry into pathological targets due to the natural physiological barriers in the human body. − For instance, the optimal diameter of particles for pulmonary delivery is usually 1–3 μm .…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Red Blood Cell-Mimicking Janus Microparticles with Enhanced Upconversion Luminescence and Drug Delivery Performance Using Double-Needle Electrospray

Cui

et al. 2023

ACS Appl. Polym. Mater.

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The shape and function of micro-/nano-particles for loading drugs play an important role in the transportation process of the drug delivery system. This study successfully fabricated red blood cell (RBC)-mimicking Janus microparticles (JMPs) using doubleneedle electrospray, which contained porous Fe 3 O 4 magnetic nanoparticles (MNPs) and upconversion (UC) luminescent nanoparticles NaYF 4 :Yb 3+ ,Er 3+ and exhibited a unique two-compartment structure. The JMPs possessed excellent magnetic and UC luminescent properties, as well as good hemocompatibility and cellular compatibility. Importantly, the two compartments of the Janus structure significantly enhanced the UC luminescent intensity compared to single compartment microparticles by reducing direct interactions between Fe 3 O 4 MNPs and UC luminescent materials. By utilizing the porous structure of Fe 3 O 4 MNPs, doxorubicin hydrochloride was loaded into Fe 3 O 4 MNPs and then embedded into the JMPs resulting in a slow-release effect. Given the excellent properties of magnetic and UC luminescence, biocompatibility, and drug slow-release ability, the RBC-mimicking JMPs have significant potential for drug delivery and bioimaging applications.

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“…The treatment of GBM is generally chemotherapy and radiation therapy after surgery [2]. Temozolomide (TMZ) drugs are often used as chemotherapy for glioblastoma [3]. High-dose steroids can be used to help reduce swelling and symptoms.…”

Section: Introduction Of Brain Glioblastomamentioning

confidence: 99%

Progress and Viewpoints of Multifunctional Composite Nanomaterials for Glioblastoma Theranostics

et al. 2022

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The most common malignant tumor of the brain is glioblastoma multiforme (GBM) in adults. Many patients die shortly after diagnosis, and only 6% of patients survive more than 5 years. Moreover, the current average survival of malignant brain tumors is only about 15 months, and the recurrence rate within 2 years is almost 100%. Brain diseases are complicated to treat. The reason for this is that drugs are challenging to deliver to the brain because there is a blood–brain barrier (BBB) protection mechanism in the brain, which only allows water, oxygen, and blood sugar to enter the brain through blood vessels. Other chemicals cannot enter the brain due to their large size or are considered harmful substances. As a result, the efficacy of drugs for treating brain diseases is only about 30%, which cannot satisfy treatment expectations. Therefore, researchers have designed many types of nanoparticles and nanocomposites to fight against the most common malignant tumors in the brain, and they have been successful in animal experiments. This review will discuss the application of various nanocomposites in diagnosing and treating GBM. The topics include (1) the efficient and long-term tracking of brain images (magnetic resonance imaging, MRI, and near-infrared light (NIR)); (2) breaking through BBB for drug delivery; and (3) natural and chemical drugs equipped with nanomaterials. These multifunctional nanoparticles can overcome current difficulties and achieve progressive GBM treatment and diagnosis results.

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Increased the TMZ concentration in brain by poly(2-ethyl-2-oxazoline) conjugated temozolomide prodrug micelles for glioblastoma treatment

Cited by 13 publications

References 54 publications

The future of poly(2-oxazoline)s

The future of poly(2-oxazoline)s

Fabrication of Red Blood Cell-Mimicking Janus Microparticles with Enhanced Upconversion Luminescence and Drug Delivery Performance Using Double-Needle Electrospray

Progress and Viewpoints of Multifunctional Composite Nanomaterials for Glioblastoma Theranostics

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