Increased Th1 activity in patients with coronary artery disease

Fernandes, Juliano Lara; Mamoni, Ronei Luciano; Orford, James L.; Garcia, Concilia; Selwyn, Andrew P.; Coelho, Otávio Rizzi; Blotta, Maria Heloı́sa Souza Lima

doi:10.1016/j.cyto.2004.01.007

Cited by 75 publications

(55 citation statements)

References 25 publications

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“…IL-18, which is also linked to IFN-␥ secretion, was constitutively detected in the circulation of all our patients and was not correlated with the IFN-␥ axis. Previous studies have reported an induction of IL-12 plasma levels in patients with myocardial infarctions vs unstable angina (6), in those presenting with unstable angina vs stable angina (7,8), and in patients with coronary atherosclerosis compared with control subjects (7). Conversely, circulating IL-18 was similar in healthy controls and patients with coronary atherosclerosis, regardless of presenting symptoms (7,9).…”

Section: Discussionmentioning

confidence: 93%

An Inflammatory Pathway of IFN-γ Production in Coronary Atherosclerosis

Ranjbaran¹,

Sokol²,

Gallo³

et al. 2007

The Journal of Immunology

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Inflammation is associated with the pathogenesis of coronary atherosclerosis, although the mechanisms remain unclear. We investigated whether cytokine secretion by innate immune responses could contribute to the production of proarteriosclerotic Th1-type cytokines in human coronary atherosclerosis. Cytokines were measured by ELISA in the plasma of patients with coronary atherosclerosis undergoing cardiac catheterization. IL-18 was detected in all subjects, whereas a subset of patients demonstrated a coordinated induction of other IFN-γ-related cytokines. Specifically, elevated plasma levels of IL-12 correlated with that of IFN-γ and IFN-γ-inducible chemokines, defining an IFN-γ axis that was activated independently of IL-6 or C-reactive protein. Systemic inflammation triggered by cardiopulmonary bypass increased plasma levels of the IFN-γ axis, but not that of IL-18. Activation of the IFN-γ axis was not associated with acute coronary syndromes, but portended increased morbidity and mortality after 1-year follow-up. IL-12 and IL-18, but not other monokines, elicited secretion of IFN-γ and IFN-γ-inducible chemokines in human atherosclerotic coronary arteries maintained in organ culture. T cells were the principal source of IFN-γ in response to IL-12/IL-18 within the arterial wall. This inflammatory response did not require, but was synergistic with and primed for TCR signals. IL-12/IL-18-stimulated T cells displayed a cytokine-producing, nonproliferating, and noncytolytic phenotype, consistent with previous descriptions of lymphocytes in stable plaques. In contrast to cognate stimuli, IL-12/IL-18-dependent IFN-γ secretion was prevented by a p38 MAPK inhibitor and not by cyclosporine. In conclusion, circulating IL-12 may provide a mechanistic link between inflammation and Th1-type cytokine production in coronary atherosclerosis.

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Section: Discussionmentioning

confidence: 93%

An Inflammatory Pathway of IFN-γ Production in Coronary Atherosclerosis

Ranjbaran¹,

Sokol²,

Gallo³

et al. 2007

The Journal of Immunology

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“…To examine the association between tic functions by interacting with the C-X-C chemokine receptor type 3 (CXCR3). An increased expression of IFN-and these IFN--inducible CXCR3 chemokines has been detected in patients with coronary artery disease 9) . An antagonist of CXCR3 was also shown to attenuate atherosclerotic plaque formation in low-density lipoprotein receptor-deficient mice by blocking the migration of CXCR3 effector T cells from the peripheral circulation into atherosclerotic lesions 10) .…”

Section: Discussionmentioning

confidence: 99%

Significant Association between Serum Monokine Induced by Gamma Interferon and Carotid Intima Media Thickness

Lee

Shin

et al. 2015

JAT

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“…IP-10 may be implicated in the development of cardiovascular disease, as it is expressed by endothelial cells, smooth muscle cells and macrophages within human atherosclerotic plaques, but not within the normal vessel wall, 23 and as patients with coronary heart disease show an enhanced expression of IP-10. 24,25 Positive correlations of IP-10 serum concentrations with body mass index (BMI) and other parameters of obesity have been reported in some, but not all studies, [25][26][27] and data regarding a potential impact of BMI on IP-10 expression on a cellular level have not been investigated.…”

Section: Introductionmentioning

confidence: 99%