Increased Testicular Steroid Concentrations in Patients With Idiopathic Infertility and Normal FSH Levels

Marie, E.; Galeraud-Denis, I.; Carreau, Serge

doi:10.1080/014850101753145870

Cited by 12 publications

(8 citation statements)

References 51 publications

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“…It is also known that hyperestrogenism is a hormonal deregulation associated with some cases of male idiopathic infertility (Lardone et al, 2010;Levalle et al, 1994;Marie et al, 2001). These findings support the idea that the elevated concentrations of estrogens are the cause underlying male infertility due to their effects on the reduction of c-KIT expression.…”

Section: Estrogenssupporting

confidence: 62%

Hormonal regulation of c-KIT receptor and its ligand: implications for human infertility?

Figueira

Cardoso

Correia

et al. 2014

Progress in Histochemistry and Cytochemistry

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Section: Estrogenssupporting

confidence: 62%

Hormonal regulation of c-KIT receptor and its ligand: implications for human infertility?

Figueira

Cardoso

Correia

et al. 2014

Progress in Histochemistry and Cytochemistry

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“…High levels of iTE2 were found in control testes (mean, 11,000 Ϯ 3,300 pmol/liter), approximately 2.3 times higher than those previously reported in human spermatic vein sampling in normal men (54), but somewhat lower than the results of a biopsy study of previously well men in stage IV coma in an intensive care unit setting during the process of multiple organ sampling (44,100 Ϯ 7,340 pmol/liter) (55). Control men displayed a 3-fold larger testes:serum E2 concentration gradient (ϫ407) than that seen for T (ϫ120).…”

Section: Testicular Steroidscontrasting

confidence: 47%

Effects of Testosterone and Levonorgestrel Combined with a 5α-Reductase Inhibitor or Gonadotropin-Releasing Hormone Antagonist on Spermatogenesis and Intratesticular Steroid Levels in Normal Men

Matthiesson

Stanton

O’Donnell

et al. 2005

The Journal of Clinical Endocrinology & Metabolism

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A similar high testicular:serum gradient exists for E2 and T in normal men, and 8 wk of gonadotropin suppression markedly reduces iTT, with 5alpha-reduced androgens and E2 levels decreasing to a much lesser degree. The heterogeneity of the germ cell response, regardless of treatment, gonadotropins or iT steroids, points to the individual sensitivity of sites in germ cell development, which is worthy of additional exploration.

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“…However, oestradiol levels were not determined in this study (Zalata et al ., 1995). Seminal plasma oestradiol levels were lower in infertile men with varicocele (Micic et al ., 1986), whereas the concentrations of intratesticular testosterone and oestradiol levels in testicular tissues obtained at autopsy were higher in infertile men than in controls (Marie et al ., 2001). Higher intratesticular concentrations of oestradiol with a lower testoste‐rone/oestradiol ratio was shown in infertile men with high serum FSH levels (Levalle et al ., 1994).…”

Section: Discussionmentioning

confidence: 99%

Seminal plasma androgen/oestrogen balance in infertile men

et al. 2002

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The hypothesis that the balance between oestrogen and androgen in seminal plasma is important for normal fertility was investigated. We determined the concentrations of oestradiol and testosterone in blood and seminal plasma from 62 infertile men and 32 normozoospermic men. Infertile men were classified according to semen analysis (concentration, motility and morphology): asthenozoospermia, oligozoospermia and oligoteratoasthenozoospermia. Serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were determined in all participants. For all subjects, mean testosterone levels were lower and mean oestradiol were higher in seminal plasma than in blood. Seminal plasma testosterone levels were lower in the infertile groups vs. control men ( p < 0.0002). Oligpzoospermic and oligoteratoasthenozoospermic men had significantly higher seminal plasma oestradiol levels compared with controls ( p < 0.03). The three infertile groups had significantly lower seminal plasma testosterone/oestradiol ratio than control men ( p < 0.001). Sperm analysis data (concentration, motility and morphology) significantly correlated with seminal plasma testosterone/oestradiol ratio. The findings of elevated seminal plasma oestradiol, decreased testosterone and testosterone/oestradiol ratio in infertile men, and the significant correlation between hormone levels and sperm analysis data suggest that the local balance between androgen and oestrogen is important for spermatogenesis.

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Increased Testicular Steroid Concentrations in Patients With Idiopathic Infertility and Normal FSH Levels

Cited by 12 publications

References 51 publications

Hormonal regulation of c-KIT receptor and its ligand: implications for human infertility?

Hormonal regulation of c-KIT receptor and its ligand: implications for human infertility?

Effects of Testosterone and Levonorgestrel Combined with a 5α-Reductase Inhibitor or Gonadotropin-Releasing Hormone Antagonist on Spermatogenesis and Intratesticular Steroid Levels in Normal Men

Seminal plasma androgen/oestrogen balance in infertile men

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