Increased temporal patterns in choice responding and altered cognitive processes in schizophrenia and mania

Lyon, Melvin; Kemp, Aaron S.

doi:10.1007/s00213-003-1646-0

Cited by 24 publications

(1 citation statement)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These algorithms have been tested on numerous data sets (Lyon and Kemp, 2004; Kerepesi et al, 2005; Kemp et al, 2008; Castaner et al, 2009), including several reports using laboratory mice and rats in anxiety testing and stereotypy (Bonasera et al, 2008; Casarrubea et al, 2010a,b). Here we briefly explain the detection algorithm but more details are presented in a theoretical paper (Magnusson, 2000).…”

Section: Methodsmentioning

confidence: 99%

Behavioral Patterns Associated with Chemotherapy-Induced Emesis: A Potential Signature for Nausea in Musk Shrews

Horn¹,

Henry²,

Meyers³

et al. 2011

Front. Neurosci.

View full text Add to dashboard Cite

Nausea and vomiting are common symptoms in patients with many diseases, including cancer and its treatments. Although the neurological basis of vomiting is reasonably well known, an understanding of the physiology of nausea is lacking. The primary barrier to mechanistic research on the nausea system is the lack of an animal model. Indeed investigating the effects of anti-nausea drugs in pre-clinical models is difficult because the primary readout is often emesis. It is known that animals show a behavioral profile of sickness, associated with reduced feeding and movement, and possibly these general measures are signs of nausea. Studies attempting to relate the occurrence of additional behaviors to emesis have produced mixed results. Here we applied a statistical method, temporal pattern (t-pattern) analysis, to determine patterns of behavior associated with emesis. Musk shrews were injected with the chemotherapy agent cisplatin (a gold standard in emesis research) to induce acute (<24 h) and delayed (>24 h) emesis. Emesis and other behaviors were coded and tracked from video files. T-pattern analysis revealed hundreds of non-random patterns of behavior associated with emesis, including sniffing, changes in body contraction, and locomotion. There was little evidence that locomotion was inhibited by the occurrence of emesis. Eating, drinking, and other larger body movements including rearing, grooming, and body rotation, were significantly less common in emesis-related behavioral patterns in real versus randomized data. These results lend preliminary evidence for the expression of emesis-related behavioral patterns, including reduced ingestive behavior, grooming, and exploratory behaviors. In summary, this statistical approach to behavioral analysis in a pre-clinical emesis research model could be used to assess the more global effects and limitations of drugs used to control nausea and its potential correlates, including reduced feeding and activity levels.

show abstract