Increased telomerase activity is associated with shorter survival in patients with chronic phase chronic myeloid leukemia

Abstract

Eine enantioselektive Diborierung von terminalen Alkenen mit chiralem 1 und Bis(pinakolato)dibor (B2pin2) wurde entwickelt. Die anschließende Oxidation des Dibor‐Addukts mit Natriumperoxoborat ergab die entsprechenden optisch aktiven 1,2‐Diole mit hohen Ausbeuten und Enantioselektivitäten.

Which has greater effects on leukomogenesis in Philadelphia chromosome positive leukemias: fusion or cell type?

“…In this study, extremely high telomerase activity was found with short telomere length in p190-transformed myeloid cells as similar with the former studies about AML [30][31][32][33]. In addition to this, high telomerase activity of p210-transformed cells has been concordant with the data of previous studies which have reported that telomerase reactivation occurred in the blastic crisis of CML.…”

“…Telomerase activity is increased in blastic crisis of CML. The telomerase reactivation has been triggered by not only shortened telomere length but also increased blastic cell ratio [29,31,32]. In our study we observed significantly incre- ased telomerase activity and shortened telomere length in p190BCR-ABL transformed lymphoid cells as similar to the previous reports [29][30][31][32][33].…”

“…It has been shown that, telomerase activity regulates the cell proliferation capacity, but this regulation is achieved not only by controlling the telomere length but also via different interactions with several key regulators of cell cycle. Short telomere length with increased telomerase activity was observed in the diagnosis of AML [29][30][31][32]. But in same phase of CML, low telomerase activity with short telomere length was reported [29][30][31][32][33][34][35][36].…”

Telomerase is limiting the growth of acute myeloid leukemia cells

“…50 Our results support the notion that telomerase activity in AML is associated with disease progression and that high levels of telomerase activity indicate a poor prognosis. 19,20,[51][52][53] As telomerase activity appears largely restricted to malignant cells, telomerase activity measurements may help with the prognosis and the evaluation of antileukemic treatments and disease progression. The value of telomerase inhibition in leukemia treatment needs to be established in clinical trials in combination with standard antileukemic agents.…”

Telomere dysfunction and its role in haematological cancer

“…TA has been reported to be a prognostic marker indicating a shorter time to progression and shortened survival in patients in CP (Broccoli et al, 1995;Ohyashiki et al, 1997b;Verstovsek et al, 2003). However, this is not clear-cut and two studies have questioned whether TA is truly increased in CML.…”