Increased Tear Osmolarity in Patients with Severe Cases of Conjunctivochalasis

Fodor, Eszter; Kosina-Hagyó, Krisztina; Bausz, Mária; Németh, János

doi:10.3109/02713683.2011.623810

Cited by 15 publications

(16 citation statements)

References 24 publications

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“…But in mild and moderate cases HLA-DR expression was similar to normal controls. In another study of Fodor et al15 the authors reported that tear osmolarity is elevated in only severe CCh; in mild and moderate cases, tear osmolarity was similar to normal controls. Zhang et al16 compared tear protein between CCh and normal controls.…”

Section: Discussionmentioning

confidence: 87%

Clinical characteristics of patients with conjunctivochalasis

Balcı¹

2014

OPTH

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PurposeTo evaluate the clinical characteristics of patients with conjunctivochalasis (CCh).Methods and materialsThis retrospective study enrolled 30 subjects diagnosed with conjunctivochalasis. Complete ophthalmic examination, including visual acuity assessment, slit-lamp examination, applanation tonometry, dilated funduscopy, tear break-up time, Schirmer 1 test, and fluorescein staining were performed in all patients. Age, sex, laterality, ocular history, symptoms, and clinical findings were recorded.ResultsThe study included 50 eyes from 30 cases. Ages ranged from 45 to 80 years, with a mean age of 65±10 years. CChs grading were as follows: 30 (60%) eyes with grade 1 CCh; 15 (30%) eyes with grade 2 CCh; and five (10%) eyes with grade 3 CCh. CCh was located in the inferior bulbar conjunctiva in 45 (90%) eyes, and in the remaining five (10%) CCh was located in the superior bulbar conjunctiva. Ten (33.3%) patients had no symptoms. Dryness, eye pain, redness, blurry vision, tired eye feeling, and epiphora were the symptoms encountered in the remaining twenty (63.6%) patients. Altered tear meniscus was noted in all cases. The mean tear break-up time was 7.6 seconds. The mean Schirmer 1 test score was 7 mm. Pinguecula was found in ten patients.ConclusionDryness, eye pain, redness, blurry vision, and epiphora were the main symptoms in patients with CCh. Dryness, eye pain, and blurry vision were worsened during downgaze and blinking. So CCh should be taken into consideration in the differential diagnosis of chronic ocular irritation and epiphora.

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Section: Discussionmentioning

confidence: 87%

Clinical characteristics of patients with conjunctivochalasis

Balcı¹

2014

OPTH

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“…However, we found low levels of HLA‐DR expression compared to those found in KCS or secondary to drugs with preservative; this is probably why osmolarity was not increased in our series. A change in tear osmolarity probably requires substantial disturbance of the ocular surface (Fodor et al. 2011).…”

Section: Discussionmentioning

confidence: 99%

Ocular surface assessment in soft contact lens wearers; the contribution of tear osmolarity among other tests

Muselier-Mathieu

Bron

Mathieu

et al. 2013

Acta Ophthalmologica

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ABSTRACT:Purpose: To determine whether tear osmolarity contributes to the assessment of the ocular surface in soft contact lens (CL) wearers. Methods: Prospective, case-control series in 44 CL wearers (28 tolerant and 16 intolerant) and 34 healthy subjects. Every patient underwent a thorough ophthalmic examination with a tear osmolarity test (TearLab System), conjunctival impression cytology and meibomian lipid sampling. Symptoms, break-up time (BUT), tear osmolarity, conjunctival expression of HLA-DR and meibomian fatty acid composition were evaluated. Results: Tear osmolarity did not differ between controls and CL wearers (p = 0.23). Flow cytometry results expressed in antibody-binding capacity (ABC) units and percentage of positive cells revealed a significant difference between the intolerant CL wearer group and the control group (p < 0.0001). Comparisons between tolerant and intolerant CL wearers showed only a significant difference for mean fluorescence levels expressed in ABC units (p < 0.0001). The BUT was significantly shorter in intolerant and tolerant CL wearers subjects than in healthy subjects (p < 0.0001), whereas there was no significant difference in meibomian fatty acid composition (p = 0.99) between the two groups. Conclusion: Contact lens wear is responsible for ocular surface alterations whose patterns are very similar to those reported in early dry-eye syndrome. However, tear osmolarity was not modified in these selected CL wearers. The yield of tear osmolarity with TearLabÔ in assessing ocular surface disorders in CL wearers deserves further investigation.

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“…36 Severe cases have been linked to increased tear osmolarity and inflammatory markers, which are often associated with dry eye states. 37,38 Le and colleagues 39 have recently demonstrated that patients with conjunctivochalasis have significantly decreased tear film stability even compared with those with DED and have significantly higher Ocular Surface Disease Index (OSDI) scores than do normal controls.…”

Section: Conjunctival Excision and Cauterymentioning

confidence: 98%

Ophthalmic Procedures for Treatment of Advanced Ocular Surface Diseases

Bartlett¹,

Bartlett²

2015

Optometry and Vision Science

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Dry eye disease and other ocular surface diseases are complex multifactorial disorders often characterized by ocular surface inflammatory changes, instability of the tear film, and functional vision impairment. Recent research has led to new concepts regarding diagnosis and management, and therapeutic interventions now include ocular lubricants, secretagogues, topical and systemic anti-inflammatory and immunosuppressive agents, tear preservation, and, for advanced cases, a variety of surgical approaches. This review considers contemporary procedures for treatment of advanced ocular surface diseases, including thermal and electrocautery of the lacrimal puncta, lid surgeries such as tarsorrhaphy, and multiple procedures to protect the exposed or compromised ocular surface.

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Increased Tear Osmolarity in Patients with Severe Cases of Conjunctivochalasis

Cited by 15 publications

References 24 publications

Clinical characteristics of patients with conjunctivochalasis

Clinical characteristics of patients with conjunctivochalasis

Ocular surface assessment in soft contact lens wearers; the contribution of tear osmolarity among other tests

Ophthalmic Procedures for Treatment of Advanced Ocular Surface Diseases

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