Increased synthesis rate of fibrinogen as a basis for its  elevated plasma levels in obese female adolescents

Balagopal, Prabhakaran; Sweeten, Shawn; Mauras, Nelly

doi:10.1152/ajpendo.00412.2001

Cited by 28 publications

(21 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Of note, the magnitudes of change (D-drop) in the FSR of fibrinogen and its concentration were closely correlated. The higher baseline FSR of fibrinogen in obese vs. lean children (both genders) in the current study was similar to the data from an unrelated study in only female adolescents [25]. Volpi et al…”

Section: Discussionsupporting

confidence: 90%

Response of fractional synthesis rate (FSR) of fibrinogen, concentration of D‐dimer and fibrinolytic balance to physical activity‐based intervention in obese children

Balagopal

George

Sweeten

et al. 2008

Journal of Thrombosis and Haemostasis

View full text Add to dashboard Cite

Summary. Background: Physical activity-induced reduction in obesity-related hyperfibrinogenemia in children has been reported. The underlying mechanisms remain elusive. Further, the effect of such interventions on fibrinolysis in children is scarce. Objectives: To investigate in obese children, before and after a physical activity-based intervention: (i) the mechanistic role of fractional synthesis rate (FSR) of fibrinogen in the reduction of hyperfibrinogenemia; and (ii) the changes in fibrinolytic factors. Methods: Subjects included 21 (age > 14 < 18 years; Tanner stage, IV-V) children (15 obese, BMI >95%tile for age and sex and six lean, BMI <85%tile). After baseline measurements of FSR of fibrinogen, and concentrations of fibrinogen, D-dimer, PAI-1 and t-PA in all children, studies were repeated after a 3-month randomized controlled physical activity-based lifestyle intervention in obese children only. Results: FSR of fibrinogen was higher (P = 0.002) in the obese (vs. lean) group, which was reduced (P = 0.001) after intervention. This almost completely accounted for the reduction in obesity-related hyperfibrinogenemia. High levels of D-dimer decreased (P = 0.001) after intervention, whereas fibrinolysis was not enhanced. Conclusions: The direct reduction in the FSR of fibrinogen and the remarkable correlation between the magnitudes of reduction in fibrinogen FSR and concentration signify a mechanistic role for FSR in the regulation of physical activity-induced reversal of hyperfibrinogenemia in obese children. The congruent reductions in the FSR of fibrinogen and the concentrations of fibrinogen and D-dimer in response to intervention despite depressed fibrinolysis suggest an overall improvement in the hypercoagulable state in obese children with physical activity-based lifestyle intervention.

show abstract

Section: Discussionsupporting

confidence: 90%

Response of fractional synthesis rate (FSR) of fibrinogen, concentration of D‐dimer and fibrinolytic balance to physical activity‐based intervention in obese children

Balagopal

George

Sweeten

et al. 2008

Journal of Thrombosis and Haemostasis

View full text Add to dashboard Cite

show abstract

“…The apparent insulin resistance observed in the obese subjects in the current study further indicates that the increased protein turnover in obese adolescents is a sign of insulin resistance as reported in previous studies 4,10,40 and suggests a defective suppression of WBPT in obese adolescents. Previous studies have also suggested that the greater peripheral hyperinsulinemia present in obesity could contribute to insulin resistance with respect to proteolysis as well as glucose disposal.…”

Section: Discussionsupporting

confidence: 88%

Effect of lifestyle changes on whole-body protein turnover in obese adolescents

et al. 2003

View full text Add to dashboard Cite

OBJECTIVE:To investigate the effect of lifestyle changes on whole-body protein turnover (WBPT) in obese adolescents. DESIGN/METHODS: Randomized and controlled nonpharmacological intervention study of WBPT in obese adolescents using stable isotope dilution techniques. SUBJECTS AND MEASUREMENTS:We studied a total of 21 adolescents (11 boys and 10 girls, matched for their pubertal status) of which 15 were obese (age ¼ 15.870.4 y old and BMI ¼ 38.673.3 kg/m 2 ) and six were lean controls (age ¼ 16.070.4 y old and BMI ¼ 21.371.2 kg/m 2 ). The obese subjects were subjected to a randomized controlled lifestyle intervention program that involved moderate physical activity and diet changes for 3 months. A group of lean age-matched subjects was also studied at baseline to compare the WBPT in obese and lean adolescents. The studies were performed during a primed, continuous infusion of L-[1-13 C]leucine. Leucine appearance rate (Leu Ra) was used as an index of whole protein breakdown and the nonoxidative portion of leucine disposal (NOLD) as an index of whole-body protein synthesis. RESULTS: The obese groups showed significantly higher body mass index (BMI), fat mass (FM), percent body fat (%BF), fat-free mass (FFM), resting energy expenditure (REE) and WBPT compared to the lean controls. The intervention program resulted in a redistribution of the parameters of body composition without apparent changes in BMI or body weight. There was a significant decrease in WBPT in the obese intervention group, but not in the obese control group. Insulin levels also decreased significantly in the obese group after intervention but not in the obese control group, whereas the glucose concentrations remained normal in all groups at baseline and also after intervention/or control. CONCLUSIONS: Results from the current study suggest: (i) abonormalities of protein metabolism occur early in the clinical course of obesity and (ii) these abnormalities are modifiable by moderate lifestyle changes in obese adolescents. The mechanism for these changes in WBPT in obese adolescents as well as their impact on specific cardiovascular risk factors and turnover of specific proteins will require further investigation.

show abstract

“…In this respect, it has been demonstrated that most overweight children become obese adults. 22 Indeed, childhood overweight has been shown to produce an adverse risk factor profile during adulthood. 21 -23 Subsequently, the critical duration of exposure to these risk factors may accumulate at an earlier time point, resulting in premature signs of cardiovascular disease.…”

Section: 17 -21mentioning

confidence: 99%

Obesity and target organ damage: the heart

Schunkert

2002

Int J Obes

View full text Add to dashboard Cite

In most patients, coronary atherosclerosis or congestive heart failure develop as an integrated response to multiple cardiovascular risk factors. Obesity increases the prevalence of most cardiovascular risk factors and is the predominant cause of diabetes mellitus and arterial hypertension. Moreover, obesity shifts the manifestation of these risk factors to younger age groups, such that subsequent damage results prematurely in clinically overt cardiac diseases. In addition, due to clustering of obesity-related risk factors, obesity may amplify the risk by synergistic mechanisms acting in parallel. Finally, an elevated body mass index (BMI) results in an increase in heart rate and blood volume, as well as increased systolic and diastolic blood pressure. These changes affect cardiac geometry and mass in addition to the alterations of the coronary vasculature. At the population level, the role of obesity in promoting multiple risk factors and, subsequently, the development of heart diseases cannot be underestimated. In individual patients, however, the clinical presentation may be dominated by obesity-related hypertension, diabetes, metabolic and inflammatory derangements or clinical symptoms of heart failure or coronary artery disease. Weight reduction remains a crucial component of the therapeutic strategy to ameliorate insulin resistance, hypertension and left ventricular hypertrophy, among other risk factors, with profound implications for the individual's prognosis.

show abstract

Increased synthesis rate of fibrinogen as a basis for its elevated plasma levels in obese female adolescents

Cited by 28 publications

References 48 publications

Response of fractional synthesis rate (FSR) of fibrinogen, concentration of D‐dimer and fibrinolytic balance to physical activity‐based intervention in obese children

Response of fractional synthesis rate (FSR) of fibrinogen, concentration of D‐dimer and fibrinolytic balance to physical activity‐based intervention in obese children

Effect of lifestyle changes on whole-body protein turnover in obese adolescents

Obesity and target organ damage: the heart

Contact Info

Product

Resources

About