Increased Susceptibility to <i>Helicobacter pylori</i> Infectionin Pregnancy

Lanciers, S; Despinasse, B.; Mehta, Devendra I.; Blecker, Uwe

doi:10.1155/s1064744999000332

Cited by 31 publications

(37 citation statements)

References 18 publications

(24 reference statements)

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“…Indeed, these authors suggested that pregnancy itself may increase the susceptibility to H.pylori infection (Lanciers et al, 1999). We did not demonstrate any relationship between H.pylori infection and obstetric cholestasis, spontaneous preterm delivery, pregnancy-related hypertension or fetal growth disorders.…”

Section: Discussioncontrasting

confidence: 74%

Helicobacter pylori seropositivity and pregnancy-related diseases: a prospective cohort study

Cardaropoli

Giuffrida

Piazzese

et al. 2015

Journal of Reproductive Immunology

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Section: Discussioncontrasting

confidence: 74%

Helicobacter pylori seropositivity and pregnancy-related diseases: a prospective cohort study

Cardaropoli

Giuffrida

Piazzese

et al. 2015

Journal of Reproductive Immunology

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“…A recent study indicated an increased susceptibility to Helicobacter pylori in pregnancy. 33 We could not assess this issue due to the lack of information on Helicobacter pylori infection. Further clarification of this issue is needed.…”

Section: Resultsmentioning

confidence: 99%

Height, weight, menstrual and reproductive factors and risk of gastric cancer among Japanese postmenopausal women: Analysis by subsite and histologic subtype

Inoue

Ito

Tajima

et al. 2001

Intl Journal of Cancer

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To clarify whether reproductive factors have an impact on gastric cancer in Japanese females, a case-control study was conducted using data from the Hospital-based Epidemiologic Research Program at Aichi Cancer Center (HERPACC), Japan. The study subjects included 365 postmenopausal women with gastric cancer and 1,825 age-class frequencymatched noncancer outpatients presenting at Aichi Cancer Center in 1988 -1998. Cases were further divided with regard to the anatomic subsite (upper third, middle third, lower third) and histologic subtypes (differentiated, nondifferentiated) and the association was evaluated using odds ratios Despite a decreasing trend, gastric cancer remains a major public health problem in Japan. The latest estimate shows that 22% of Japanese cancers occurred in the stomach in 1996, 1 and gastric cancers accounted for 18% of total cancer deaths in 1998. 2 It is well known that gastric cancer as a whole is more common in males, the male to female ratio being 1.5-3 in the incidence, 3 although this varies with the age group, 4 -6 values only being greater than 1 in middle-and old-aged groups. These observations suggest that the etiology of female gastric cancer may be different between the young and the old and therefore they should be considered separately.A previous study on gastric cancer in young individuals indicated an elevated risk of gastric cancer with pregnancy and delivery episode 7 and suggested that the sex hormones can influence the development of this cancer. 8 -10 On the other hand, the male predominance of this cancer in older age groups allows us to speculate some link not only with lifestyle factors such as smoking and dietary habits but also with a protective function of femalerelated factors. Our working hypothesis for our study was that whereas a male predominant lifestyle, including smoking, may increase the risk, long term exposure to female-related factors over a long fertile life may reduce the likelihood of gastric cancer. To our knowledge, epidemiologic studies targeting this issue hitherto have only been conducted in Western countries 11-21 and the results were not consistent, suggesting the need for separate analysis by subsite and histologic subtype. 17 To gain further epidemiologic evidence on any association between gastric cancer and female-related factors such as menstrual and reproductive factors among postmenopausal women, a comparative case-control study was therefore undertaken using data from the Hospital-based Epidemiologic Research Program at Aichi Cancer Center (HERPACC). This study aimed to clarify whether these factors exhibit any impact on development of different types of gastric cancers in postmenopausal Japanese women. MATERIAL AND METHODSHERPACC was begun in Nagoya, Japan, in 1988, with information on lifestyle factors routinely collected from all first-visit outpatients, using a self-administered questionnaire checked by a trained interviewer. Each patient was asked about his or her lifestyle when healthy or before the current symptoms developed...

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“…It has been reported that pregnancy is associated with changes in both humoral and cell-mediated immunity during different gestational periods, which may lead to an increased susceptibility to H. pylori infection [12]. The aim of the present study was to characterize the MT expression in pregnant mice infected with either H. pylori or H. felis and in their fetuses and pups.…”

Section: Introductionmentioning

confidence: 94%

Metallothionein Expression in Helicobacter-Infected Pregnant Mice and Their Fetuses and Pups

2007

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Metallothionein (MT) expression was investigated in pregnant mice infected with H. pylori or H. felis and their fetuses and pups. Mice, healthy or infected with H. pylori or H. felis (n = 18/group), were sacrificed 2 weeks after impregnation or 4 weeks postpartum. Pups were sacrificed as fetuses, after birth, or at ages 11 or 28 days. Whole fetuses, stomachs, small intestines, and livers were assayed for MT. MT was increased (P<0.05) by two- and threefold in fetuses from H. pylori- and H. felis-infected mothers, respectively, compared to control fetuses. Stomach MT of H. felis-infected pregnant mice, and newborns and 28-day pups from H. felis-infected mothers, was elevated (P<0.05) twofold compared to that of control mice and pups. Liver MT was decreased (P<0.05) in H. felis-infected mice 4 weeks postpartum (18%) and in their 11-day (69%) and 28-day (53%) pups, while small intestinal MT was decreased in H. felis-infected pregnant mice (17%), H. felis-infected mice 4 weeks postpartum (19%), and their 11-day pups (35%), compared to control mice. H. felis infection altered MT levels of pregnant mice, their fetuses and pups, and mice postpartum, which may be a response to the marked inflammation.

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Increased Susceptibility to Helicobacter pylori Infectionin Pregnancy

Abstract: Obstet. Gynecol. 7:195-198, 1999. (C)

Cited by 31 publications

References 18 publications

Helicobacter pylori seropositivity and pregnancy-related diseases: a prospective cohort study

Helicobacter pylori seropositivity and pregnancy-related diseases: a prospective cohort study

Height, weight, menstrual and reproductive factors and risk of gastric cancer among Japanese postmenopausal women: Analysis by subsite and histologic subtype

Metallothionein Expression in Helicobacter-Infected Pregnant Mice and Their Fetuses and Pups

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