Increased susceptibility of prenatal food restricted offspring to high-fat diet-induced nonalcoholic fatty liver disease is intrauterine programmed

Zhang, Li; Shen, Lang; Xu, Dan; Wang, Linlong; Guo, Yuming; Liu, Zhongfen; Liu, Lian; Magdalou, Jacques; Chen, Liaobin; Wang, Hui

doi:10.1016/j.reprotox.2016.08.006

Cited by 10 publications

(10 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increased neonatal FRs in the FGR-MNR offspring likewise indicate higher growth rates relative to initial size thereby reflecting a greater partitioning of nutrients toward growth in these animals. This finding of early catch-up growth in guinea pigs born FGR after moderate MNR is similar to that seen in other species with induced FGR (7,21,24,31,36,46,50) and in humans born growth restricted (1,2,5,16,17,28,30,39), albeit with the degree of catch-up growth also dependent on postnatal dietary conditions. Neonatal FRs were negatively correlated to birth weights in the FGR-MNR animals, which was also reported by Kind et al (31) in FGR guinea pigs, indicating that the degree of growth restriction at birth also impacts the degree of catch-up growth.…”

Section: Discussionsupporting

confidence: 87%

“…Liver FRs were increased~69% in the FGR-MNR neonates indicating a greater degree of catch-up growth than in any of the other organs studied. Enhanced growth in the liver has also been reported in low birth weight lambs (22) and is again likely to involve increased insulin signaling activity and thereby glycogen and/or lipid accumulation (50), with increased risk for nonalcoholic fatty liver disease as seen in FGR offspring (17,50). Kidney FRs were increased in a similar manner to that of the whole body in the FGR-MNR neonates indicating similar catch-up growth.…”

Section: Discussionmentioning

confidence: 66%

“…Kidney FRs were increased in a similar manner to that of the whole body in the FGR-MNR neonates indicating similar catch-up growth. This is likely to involve increased insulin-signaling activity as for other visceral tissues and whole body catch-up growth (5,8,21,31,36,46,47,50). Testes and ovary weights were decreased~25% in the FGR-MNR neonates and more so than the other organs studied except for the R652 heart.…”

Section: Discussionmentioning

confidence: 96%

See 2 more Smart Citations

Maternal nutrient restriction in guinea pigs as an animal model for studying growth-restricted offspring with postnatal catch-up growth

Nevin

Formosa

Maki

et al. 2018

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

We determined the impact of moderate maternal nutrient restriction (MNR) in guinea pigs with fetal growth restriction (FGR) on offspring body and organ weights, hypothesizing that FGR-MNR animals will show catch-up growth but with organ-specific differences. Guinea pig sows were fed ad libitum (Control) or 70% of the control diet from 4 weeks preconception, switching to 90% at midpregnancy (MNR). Control newborns >95 g [appropriate for gestational age (AGA); n = 37] and MNR newborns <85 g (FGR; n = 37) were monitored until neonatal (~25 days) or adult (~110 days) necropsy. Birth weights and body/organ weights at necropsy were used to calculate absolute and fractional growth rates (FRs). FGR-MNR birth weights were decreased ~32% compared with the AGA-Controls. FGR-MNR neonatal whole body FRs were increased ~36% compared with Controls indicating catch-up growth, with values negatively correlated to birth weights indicating the degree of FGR leads to greater catch-up growth. However, the increase in organ FRs in the FGR-MNR neonates compared with Controls was variable, being similar for the brain and kidneys indicating comparable catch-up growth to that of the whole body and twofold increased for the liver but negligible for the heart indicating markedly increased and absent catch-up growth, respectively. While FGR-MNR body and organ weights were unchanged from the AGA-Controls by adulthood, whole body growth rates were increased. These findings confirm early catch-up growth in FGR-MNR guinea pigs but with organ-specific differences and enhanced growth rates by adulthood, which are likely to have implications for structural alterations and disease risk in later life.

show abstract

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Maternal nutrient restriction in guinea pigs as an animal model for studying growth-restricted offspring with postnatal catch-up growth

Nevin

Formosa

Maki

et al. 2018

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

show abstract

“…GC inhibits expression and secretion of IGF1 in many organs, which leads to the conclusion that under the adverse uterine environment, serum IGF1 level is affected by the high GC concentration . After birth, offspring IGF1 is no longer inhibited by excess maternal GC, and simultaneously, deficient development of neuroendocrine metabolic function leads to a low GC level in postnatal offspring, thus IGF1 level increases in IUGR offspring . Our recent work found that serum corticosterone of PNE pup increased significantly in uterine, but decreased in adulthood.…”

Section: Discussionmentioning

confidence: 98%

Synergistic effects of prenatal nicotine exposure and post‐weaning high‐fat diet on hypercholesterolaemia in rat offspring of different sexes

Zhu

Guo

Luo

et al. 2019

Basic Clin Pharma Tox

Self Cite

View full text Add to dashboard Cite

Hypercholesterolaemia is considered a disease with intrauterine origin. Recently, we reported that prenatal nicotine exposure (PNE) induced an abnormal level of total cholesterol in rat offspring before and after birth. However, there were little data about sex differences in serum cholesterol level in PNE offspring. In addition, many previous studies reported that blood cholesterol is associated with daily diet. This study was designed to analyse the interaction among PNE, high-fat diet (HFD) and sex on cholesterol metabolism in the rat. Pregnant Wistar rats were administered 2 mg/kg nicotine subcutaneously from gestational day (GD) 11 until parturition. After weaning, pups were fed with normal diet or HFD till 24 weeks, and then, serum cholesterol phenotypes and hepatic cholesterol metabolism-related genes were tested. Results showed that PNE manifested a distinct programming effect on cholesterol phenotype and cholesterol metabolism-related genes. HFD aggregated PNE-induced hypercholesterolaemia in adult offspring and exacerbated liver cholesterol metabolism dysfunction in PNE offspring. There was no sex difference in serum cholesterol level, but there were interactions among PNE, HFD and sex on cholesterol metabolic genes in adult offspring, which indicates that cholesterol metabolism in female offspring is more likely to be affected by PNE and HFD. In conclusion, HFD exacerbated PNE-induced hypercholesterolaemia, and sex differences existed in liver cholesterol metabolic genes in PNE-or HFDtreated offspring. K E Y W O R D Shigh-fat diet, hypercholesterolemia, liver cholesterol metabolism, pregnancy nicotine exposure, sex

show abstract

“…All pups in the four groups were fed an HFD ( provided 4.45 kcal g −1 diet, which contained 18.5% of its energy from protein, 51.8% from carbohydrate and 29.7% from fat) from PW4 to PW24, as previously reported by our laboratory. 30 At PW21, the offspring rats in the control and PFR groups with chronic stress were exposed to UCS for three weeks. The method of UCS employed in the present study was based on our previous studies.…”

Section: Animals and Treatmentmentioning

confidence: 99%

Prenatal food restriction induces neurobehavioral abnormalities in adult female offspring rats and alters intrauterine programming

Zhang

et al. 2018

Toxicol. Res.

Self Cite

View full text Add to dashboard Cite

The higher risk of adult neuropsychiatric diseases in individuals with low fetal birth weight may be related to brain-derived neurotrophic factor (BDNF) signaling pathway inhibition. Here, we investigated whether prenatal food restriction (PFR) induces neurobehavioral alterations in adult female offspring and explored the underlying intrauterine programming mechanism. Pregnant Wistar rats in the PFR group were fed 50% of the daily food intake of control rats from gestational day (GD) 11 to 20; some pregnant rats were sacrificed at GD20, and the remaining female pups had normal delivery and were fed a post-weaning high-fat diet (HFD) and half of them were exposed to an unpredictable chronic stress (UCS) from postnatal week (PW) 21. All adult female offspring were sacrificed at PW24. At GD20, PFR altered fetal hippocampal structure and function, increased glucocorticoid receptor (GR) expression, and decreased mineralocorticoid receptor (MR), BDNF and synaptic plasticity-related gene expressions. At PW24, PFR induced depression-like behavioral abnormalities in adult rat offspring fed an HFD. These rats exhibited depression- and anxiety-like behavioral changes after HFD/UCS. Furthermore, the hippocampal morphology of the PFR group showed abnormal changes in adult offspring fed an HFD and more serious damage after HFD/UCS. These changes were accompanied by increased serum corticosterone levels, elevated GR expression, and reduced expression of the BDNF signaling pathway and synaptic plasticity-related genes in the hippocampus. In conclusion, PFR may induce neurobehavioral abnormalities in adult offspring, especially those exposed to UCS, through high levels of glucocorticoids, which increase hippocampal GR expression and decrease BDNF expression.

show abstract

Increased susceptibility of prenatal food restricted offspring to high-fat diet-induced nonalcoholic fatty liver disease is intrauterine programmed

Cited by 10 publications

References 61 publications

Maternal nutrient restriction in guinea pigs as an animal model for studying growth-restricted offspring with postnatal catch-up growth

Maternal nutrient restriction in guinea pigs as an animal model for studying growth-restricted offspring with postnatal catch-up growth

Synergistic effects of prenatal nicotine exposure and post‐weaning high‐fat diet on hypercholesterolaemia in rat offspring of different sexes

Prenatal food restriction induces neurobehavioral abnormalities in adult female offspring rats and alters intrauterine programming

Contact Info

Product

Resources

About