Increased Survivin mRNA in Malignant Pleural Effusion is Significantly Correlated with Survival

Lan, Chou Chin; Wu, Yi-Ming; Lee, Chih Hsin; Huang, Yi Chih; Huang, Chun Yao; Tsai, Ying Huang; Huang, Shiu Feng; Tsao, Thomas Chang Yao

doi:10.1093/jjco/hyp151

Cited by 16 publications

(20 citation statements)

References 25 publications

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“…No association has been detected between surviving levels of pleural effusion and age, sex, smoking states to our findings. According to previous studies increased survivin levels of mRNA expression in pleural effusion were associated with poor survival [23] [26]. Similary, in our study, elevated levels of survivin was correlated with a reduced overall survival.…”

Section: Discussionsupporting

confidence: 91%

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Diagnostic and Prognostic Value of Survivin in Pleural Effusion

Xu¹,

Xu²,

Zhao³

et al. 2018

ALC

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Background: Survivin is an inhibitor of apoptosis that may be a novel diagnostic and prognostic marker of cancer. Our study is to investigate the diagnostic and prognostic value of survivin for pleural effusions. Methods: Sixty-five pleural effusion patients were enrolled prospectively. Pleural effusion samples were examined for survivin level by ELISA. Pleural effusions were divided into three groups: Group I, malignant pleural effusion (MPE) (n = 36); Group II, tuberculous pleurisy (TPE) (n = 18); and Group III, transudative pleural effusion (n = 11). The accuracy of diagnosis and the correlation between survivin level and survival in malignant pleural effusions (MPE) were analyzed. Results: Survivin level was 320.50 ± 228.24 pg/ml in MPE, 328.35 ± 146.79 pg/ml in TPE and 318.87 ± 208.39 pg/ml in transudative pleural effusion respectively. ROC curves for MPE versus TPE were analyzed, area under the ROC curve was 0.419, and for the cutoff value of 254.85 pg/ml sensitivity was 44.4% and specificity 55.6%. Survivin had no discriminative power in differentiating exudative effusions of MPE from non-MPE (p = 0.648). There was no correlation between survivin level and age, sex. However, statistically significant difference was found between primary lung carcinoma (238.66 ± 48.19 pg/ml) and extra-pulmonary metastatic carcinomas (435.09 ± 320.62 pg/ml) according to survivin level (p = 0.033). Survivin levels can distinguish patients who had poor prognosis (median survival 96 days) and those who had good prognosis (median survival 206 days) in MPE. Conclusion: survivin levels detected with ELISA had no discriminative power in differentiating exudative effusions included MPE and TPE. However, over-expression of survivin correlates with poor prognosis in cancer patients. Our results suggest that survivin may be a potential prognostic marker in MPE.

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Section: Discussionsupporting

confidence: 91%

“…Furthermore, studies about survivin expression in pleural effusions are limited [23] [24]. Wu and colleagues [25] have analyzed pleural effusion specimens for survivin expression using ELISA.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic and Prognostic Value of Survivin in Pleural Effusion

Xu¹,

Xu²,

Zhao³

et al. 2018

ALC

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“…In fact, Lan et al (2010) have shown that high survivin level in pleural effusion is associated with poor prognosis. According to Yang et al (2009) no relationship exists between susceptibility to esophageal squamous cell carcinoma and polymorphism of both the -644T/C and the -31G/C regions.…”

Section: Discussionmentioning

confidence: 99%

Association between survivin gene promoter -31G/C and -644C/T polymorphisms and non-small cell lung cancer

Aynacı

Çoşkunpınar²,

Eren³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. Lung cancer is the most common cancer worldwide. Survivin is one of the first reported inhibitors of apoptosis proteins, which is an important family of proteins that regulate apoptosis. The survivin gene is located on human chromosome 17q25, which is composed of 142 amino acids. A common polymorphism of the survivin gene promoter -31G/C has been shown to influence cancer risk. This genetic variant has been associated with overexpression of survivin at both protein and mRNA levels in cancer cells. We examined promoter (-31G/C) genotype frequency in a patient group (N = 146), 77.4% GG, 18.5% GC, 4.1% CC, and in a control group (N = 98), 57.1% GG, 34.7% GC, 8.2% CC. These distributions were significantly different. Promoter (-644C/T) genotype frequency in the patient group was 40.4% TT, 48.6% TC, 11% CC, and in the control group it was 55.1% TT, 40.8% TC, 4.1% CC; these distributions were also significantly different. Individuals carrying the survivin 31 GC genotype and those carrying the survivin 644 CC genotype had a significantly decreased risk of having non-small cell lung cancer.

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“…There were 1044 subjects, including 614 in the case group and 430 in the control group. Table 1 shows the eligible characteristics of the articles that were published between 2006 and 2012 [15][16][17][18][19][20][21][22][23][24][25]. One study was conducted in Egypt [24], 2 were conducted in Taiwan, China [22,25], and 7 were performed in the mainland of China [15][16][17][18][19][20][21]23].…”

Section: Discussionmentioning

confidence: 99%

“…Table 1 shows the eligible characteristics of the articles that were published between 2006 and 2012 [15][16][17][18][19][20][21][22][23][24][25]. One study was conducted in Egypt [24], 2 were conducted in Taiwan, China [22,25], and 7 were performed in the mainland of China [15][16][17][18][19][20][21]23]. All 614 patients with malignant pleural effusion were confirmed by the identification of malignant cells in the pleural fluid by cytology and/or by histopathologic examination of the pleural tissue by VATS or pleural blind biopsy, which are the gold standards for malignant pleural effusion diagnosis.…”

Section: Discussionmentioning

confidence: 99%