Increased subgenual prefrontal cortex size in remitted patients with major depressive disorder

Yücel, Kaan; McKinnon, Margaret C.; Chahal, Ramandeep; Taylor, Valerie H.; MacDonald, Kathryn; Joffe, Russell T.; MacQueen, Glenda

doi:10.1016/j.pscychresns.2008.07.013

Cited by 49 publications

(35 citation statements)

References 32 publications

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“…Previous neuroimaging studies have reported that this region plays a critical role in emotion regulation. A decrease of gray matter volume in sgACC has been found in patients with bipolar disorder (Drevets et al, 1997;Hirayasu et al, 1999) and MDD (Yucel et al, 2009). In adolescents with MDD, the nerve fibers arising from the sgACC have been found to have lower FA (Cullen et al, 2010).…”

Section: Resultsmentioning

confidence: 97%

“…By the combination of sMRI and rs-fMRI analyses, Posner and associates found that structural and functional abnormalities associated with hippocampus may contribute to depressive symptoms in children with ADHD (Posner et al, 2014). We hypothesize that structural and/or functional anomalies in subgenual anterior cingulate cortex (sgACC), which plays a critical role in emotion regulation and has been found to contribute to MDD and other mood disorders (Drevets et al, 1997;Hirayasu et al, 1999;Yucel et al, 2009), may associate with impulsivity in children with ADHD, and together serve as a vulnerable marker for developing MDD and other mood disorders. In this study, we proposed to use a multimodal MRI approach, including both rs-fMRI and DTI, to investigate our hypothesis.…”

Section: Introductionmentioning

confidence: 89%

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Structural and Functional Abnormalities in Children with Attention-Deficit/Hyperactivity Disorder: A Focus on Subgenual Anterior Cingulate Cortex

Zhan

Liu

et al. 2017

Brain Connectivity

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Attention-deficit/hyperactivity disorder (ADHD), characterized by developmentally inappropriate inattention, hyperactivity/impulsivity, or a combination of both, is a major public health problem. Neuroimaging studies have revealed associations of these cognitive impairments with structural and functional deficits all over the brain. Existing findings are not fully consistent because of the heterogeneity of study samples and diversity of research techniques. In this study, we propose to utilize a multimodal magnetic resonance imaging (MRI) approach to study the structural and functional brain networks in children with ADHD-combined type (ADHD-C) with a focus on the subgenual anterior cingulate cortex (sgACC). Diffusion tensor imaging (DTI) and resting-state functional MRI (rs-fMRI) data from 32 children with ADHD-C and 32 group-matched controls were involved. Network-based statistic analysis of the rs-fMRI data revealed a disconnected functional network between the sgACC and multiple regions in the occipital lobe and cerebellum, whereas the DTI data showed disrupted white matter integrity in the subgenual cingulum bundle (sgCB). Post hoc region of interest (ROI)-based analyses showed significantly increased fluctuation of the spontaneous brain activity in the sgACC and higher radial diffusivity in the sgCB in the ADHD group. Both the rs-fMRI and DTI ROI-based measures were significantly correlated with clinical measures that examine behavioral capacities of attention and inhibitory control. Findings of this study suggest that functional alterations in the sgACC and white matter under development in the sgCB may impact each other, and together contribute to impaired attention and inhibitory control function in children with ADHD.

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Section: Resultsmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 89%

Structural and Functional Abnormalities in Children with Attention-Deficit/Hyperactivity Disorder: A Focus on Subgenual Anterior Cingulate Cortex

Zhan

Liu

et al. 2017

Brain Connectivity

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“…Finally, existing volumetric studies have mostly underestimated the volume of human sACC, since its rostral boundary is often set at the coronal plane defined by the rostral extreme of the genu of the corpus callosum (Asami et al, 2008; Frodl et al, 2008; Malykhin et al, 2012; Yucel et al, 2009). This also holds true for studies in non-human primates (Blatchley and Hopkins, 2010).…”

Section: Discussionmentioning

confidence: 99%

Functional organization of human subgenual cortical areas: Relationship between architectonical segregation and connectional heterogeneity

et al. 2015

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Human subgenual anterior cingulate cortex (sACC) is involved in affective experiences and fear processing. Functional neuroimaging studies view it as a homogeneous cortical entity. However, sACC comprises several distinct cyto- and receptorarchitectonical areas: 25, s24, s32, and the ventral portion of area 33. Thus, we hypothesized that the areas may also be connectionally and functionally distinct. We performed structural post mortem and functional in vivo analyses. We computed probabilistic maps of each area based on cytoarchitectonical analysis of ten post mortem brains. Maps, publicly available via the JuBrain atlas and the Anatomy Toolbox, were used to define seed regions of task-dependent functional connectivity profiles and quantitative functional decoding. sACC areas presented distinct co-activation patterns within widespread networks encompassing cortical and subcortical regions. They shared common functional domains related to emotion, perception and cognition. A more specific analysis of these domains revealed an association of s24 with sadness, and of s32 with fear processing. Both areas were activated during taste evaluation, and co-activated with the amygdala, a key node of the affective network. s32 co-activated with areas of the executive control network, and was associated with tasks probing cognition in which stimuli did not have an emotional component. Area 33 was activated by painful stimuli, and co-activated with areas of the sensorimotor network. These results support the concept of a connectional and functional specificity of the cyto- and receptorarchitectonically defined areas within the sACC, which can no longer be seen as a structurally and functionally homogeneous brain region.

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“…The primary hypothesis was that regionally selective alterations in brain GABAB receptor subunit gene expression are a characteristic of this disorder. The brain areas examined were the hippocampus, subgenual cingulate and orbitofrontal cortex, regions implicated in the pathophysiology of depression (Sheline, 1996;Sheline et al, 1999;Mayberg, 2003;Seminowicz et al, 2004;Pittenger and Duman, 2008;Hajszan et al, 2009;Koolschijn et al, 2009;Yucel et al, 2009;Price and Drevets, 2010). Particular emphasis was placed on subsections of the hippocampus as this is a region where the balance between excitatory and inhibitory inputs appears to be particularly critical.…”

Section: Human Gaba B Receptor Subunit Expression In Depressionmentioning

confidence: 99%

“…Within the hippocampus, alterations in the morphology of the dentate gyrus (DG), CA1 and CA3 regions occur in association with stress, depression and antidepressant therapy (Malberg et al, 2000;Pittenger and Duman, 2008;Hajszan et al, 2009). Likewise, depressionrelated volume changes occur in the subgenual cingulate cortex (Yucel et al, 2009) and the orbital frontal cortex (Koolschijn et al, 2009). Thus, these brain regions, along with cerebellar cortex, an area not believe to contribute to the symptoms of this disorder, were selected for studying possible changes in GABAB subunit expression in depression.…”

Section: Human Gaba B Receptor Subunit Expression In Depressionmentioning

confidence: 99%

The GABA_B receptor as a target for antidepressant drug action

Ghose

Winter

McCarson

et al. 2010

British J Pharmacology

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Preclinical and clinical data suggest that a modification in GABAB receptor expression and function may contribute to the symptoms of major depression and the response to antidepressants. This includes laboratory animal experiments demonstrating that antidepressants modify brain GABAB receptor expression and function and that GABAB receptor antagonists display antidepressant potential in animal models of this condition. Clinical and post-mortem studies reveal changes in GABAergic transmission associated with depression as well as depression-related changes in GABAB subunit expression that are localized to the cortical depression network. Detailed in this review are the preclinical and clinical data implicating a role for the GABAB receptor system in mediating symptoms of this disorder and its possible involvement in the response to antidepressants. Particular emphasis is placed on clinical and post-mortem studies, including previously unpublished work demonstrating regionally-selective modifications in GABAB receptor subunit expression in brain samples obtained from depressed subjects. Together with the earlier preclinical studies, these new data point to a role for the GABAB system in major depression and support the antidepressant potential of GABAB receptor antagonists.

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Increased subgenual prefrontal cortex size in remitted patients with major depressive disorder

Cited by 49 publications

References 32 publications

Structural and Functional Abnormalities in Children with Attention-Deficit/Hyperactivity Disorder: A Focus on Subgenual Anterior Cingulate Cortex

Structural and Functional Abnormalities in Children with Attention-Deficit/Hyperactivity Disorder: A Focus on Subgenual Anterior Cingulate Cortex

Functional organization of human subgenual cortical areas: Relationship between architectonical segregation and connectional heterogeneity

The GABA_B receptor as a target for antidepressant drug action

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Increased subgenual prefrontal cortex size in remitted patients with major depressive disorder

Cited by 49 publications

References 32 publications

Structural and Functional Abnormalities in Children with Attention-Deficit/Hyperactivity Disorder: A Focus on Subgenual Anterior Cingulate Cortex

Structural and Functional Abnormalities in Children with Attention-Deficit/Hyperactivity Disorder: A Focus on Subgenual Anterior Cingulate Cortex

Functional organization of human subgenual cortical areas: Relationship between architectonical segregation and connectional heterogeneity

The GABAB receptor as a target for antidepressant drug action

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Product

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The GABA_B receptor as a target for antidepressant drug action