Increased Striatal Dopamine Synthesis Capacity in Gambling Addiction

Holst, Ruth J. van; Sescousse, Guillaume; Janssen, Loes; Janssen, Marcel; Berry, Anne S.; Jagust, William J.; Cools, Roshan

doi:10.1016/j.biopsych.2017.06.010

Cited by 99 publications

(54 citation statements)

References 84 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Though studies on dopamine synthesis in GD have yielded mixed results, some evidence points to an increase in dopamine synthesis capacity . Also, consistent data points to a similar D2‐D3 receptor profile in most GD subjects compared with HC .…”

Section: Discussionmentioning

confidence: 90%

“…Alterations in dopaminergic pathways have been extensively hypothesized in GD, based on specific genetic polymorphism data (D2‐D3 receptors; and epigenetic data, as well as new onset dopamine agonist‐related behavioral addictions in Parkinson's disease (PD) . It is still unclear whether GD is a hypodopaminergic or hyperdopaminergic condition, or both.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Striatal presynaptic dopaminergic dysfunction in gambling disorder: A ¹²³I‐FP‐CIT SPECT study

et al. 2018

View full text Add to dashboard Cite

Although the involvement of dopamine in gambling disorder (GD) has long been hypothesized, its precise role remains unclear. The action of dopamine in the synapses is regulated by the dopamine transporter (DAT). We hereinafter present significant differences between a sample of 15 treatment-seeking GD subjects and 17 healthy controls in terms of striatal DAT availability, and we explore its association with reward-based decision making. We performed I-FP-CIT Single-photon emission computed tomography (SPECT) and correlated DAT binding ratios in the bilateral caudate and putamen with gambling symptoms (G-SAS, PG-YBOCS) and behaviors, as well as other psychometric variables (anhedonia and impulsivity). Gambling disorder (GD) subjects were also administered a computerized version of the Iowa gambling task (IGT) to assess reward-based decision making. We found reduced DAT availability in GD subjects compared with healthy controls (-13.30% in right caudate, -11.11% in right putamen, -11.44% in left caudate, and -11.46% in the left putamen). We also found that striatal DAT availability was inversely correlated with days spent gambling and IGT performance in GD subjects. These results provide evidence for a presynaptic dopaminergic dysfunction in striatal regions of GD subjects. Functional DAT down-regulation possibly sustains the transition towards compulsive gambling addiction, characterized both by hyperdopaminergic and hypodopaminergic states in the context of a sensitized dopaminergic system.

show abstract

Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Striatal presynaptic dopaminergic dysfunction in gambling disorder: A ¹²³I‐FP‐CIT SPECT study

et al. 2018

View full text Add to dashboard Cite

show abstract

“…In contrast to our prediction, frequentist statistics indicated a negative relationship between sEBR and Ki values (Spearman ⍴=-0.504, p=0.024, Figure 1B). As both age and gambling status are known to be related to Ki values (Berry et al, 2016;van Holst et al, 2017), we next regressed sEBR onto Ki values while adding these two variables as covariates, revealing a marginally significant negative relationship between sEBR and dopamine synthesis capacity (beta=-1.82, p=0.09).…”

Section: Resultsmentioning

confidence: 99%

“…Thirty male participants were recruited, among which were 15 pathological gamblers (PGs) and 15 matched healthy controls (HCs). The PET data from these participants have been reported in a previous study comparing baseline dopamine synthesis capacity between groups (van Holst et al, 2017). PGs were recruited through advertisement and addiction treatment centers, and reported not to be medicated or in treatment for their gambling at the time of the PET study.…”

Section: Participantsmentioning

confidence: 99%

Spontaneous eye blink rate and dopamine synthesis capacity: Preliminary evidence for an absence of positive correlation

Sescousse

Ligneul

Holst

et al. 2017

Preprint

Self Cite

View full text Add to dashboard Cite

Dopamine is central to a number of cognitive functions and brain disorders. Given the cost of neurochemical imaging in humans, behavioral proxy measures of dopamine have gained in popularity in the past decade, such as spontaneous eye blink rate (sEBR). Increased sEBR is commonly associated with increased dopamine function based on pharmacological evidence and patient studies. Yet, this hypothesis has not been validated using in vivo measures of dopamine function in humans. In order to fill this gap, we measured sEBR and striatal dopamine synthesis capacity using [ 18 F]DOPA PET in 20 participants (9 healthy individuals and 11 pathological gamblers). Our results, based on frequentist and Bayesian statistics, as well as region-of-interest and voxel-wise analyses, argue against a positive relationship between sEBR and striatal dopamine synthesis capacity. They show that, if anything, the evidence is in favor of a negative relationship. These results, which complement findings from a recent study that failed to observe a relationship between sEBR and dopamine D2 receptor availability, suggest that caution and nuance are warranted when interpreting sEBR in terms of a proxy measure of striatal dopamine.

show abstract

“…Interestingly, higher rather than lower dopamine synthesis capacity has been associated with other behavioral addictions (e.g. gambling (15); though see (16)) and behavioral disinhibition (17) indicating that dopamine synthesis capacity may interact with other factors in conferring risk for problematic social media use. One such factor may be D2 receptor density, which is positively correlated with trait extraversion in healthy adults (18).…”

Section: Discussionmentioning

confidence: 99%

Striatal dopamine synthesis capacity reflects smartphone social activity

Westbrook

Ghosh

Bosch

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Striatal dopamine has been implicated in social behavior across humans, rodents, and non-human primates in artificial laboratory settings with highly-practiced tasks and fixed reward contingencies. Whether striatal dopamine drives naturalistic, spontaneous social behavior remains unclear. Here, we leverage day-to-day logs of unconstrained smartphone behavior and establish a novel link between smartphone social activity and individual differences in striatal dopamine synthesis capacity using [18F]-DOPA PET in (N=22) healthy adult humans. We find a strong relationship such that a higher proportion of social app interactions correlates with lower dopamine synthesis capacity in the bi-lateral putamen. Permutation tests and penalized regressions provide evidence that this link between dopamine synthesis capacity and social versus non-social smartphone taps is specific. These observations provide a key empirical grounding for current speculations about dopamine’s role in digital social behavior.

show abstract

Increased Striatal Dopamine Synthesis Capacity in Gambling Addiction

Abstract: Taken together, these results provide empirical evidence for increased striatal dopamine synthesis in pathological gambling.

Cited by 99 publications

References 84 publications

Striatal presynaptic dopaminergic dysfunction in gambling disorder: A ¹²³I‐FP‐CIT SPECT study

Striatal presynaptic dopaminergic dysfunction in gambling disorder: A ¹²³I‐FP‐CIT SPECT study

Spontaneous eye blink rate and dopamine synthesis capacity: Preliminary evidence for an absence of positive correlation

Striatal dopamine synthesis capacity reflects smartphone social activity

Contact Info

Product

Resources

About

Increased Striatal Dopamine Synthesis Capacity in Gambling Addiction

Abstract: Taken together, these results provide empirical evidence for increased striatal dopamine synthesis in pathological gambling.

Cited by 99 publications

References 84 publications

Striatal presynaptic dopaminergic dysfunction in gambling disorder: A 123I‐FP‐CIT SPECT study

Striatal presynaptic dopaminergic dysfunction in gambling disorder: A 123I‐FP‐CIT SPECT study

Spontaneous eye blink rate and dopamine synthesis capacity: Preliminary evidence for an absence of positive correlation

Striatal dopamine synthesis capacity reflects smartphone social activity

Contact Info

Product

Resources

About

Striatal presynaptic dopaminergic dysfunction in gambling disorder: A ¹²³I‐FP‐CIT SPECT study

Striatal presynaptic dopaminergic dysfunction in gambling disorder: A ¹²³I‐FP‐CIT SPECT study