Increased sterol excretion with polyunsaturated-fat high-cholesterol diets

Nestel, Paul J.; Havenstein, Nathalie; Homma, Yasuhiko; Scott, TW; Cook, L. J.

doi:10.1016/0026-0495(75)90020-7

Cited by 98 publications

(33 citation statements)

References 23 publications

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“…n addition, reductions in high density lipoprotein (HDL) cholesterol levels have been found in four studies 39,43, se, 59 b u t n o t j n f o u r ot h e rs. 41 • 44 " 46 The results of both of our recent metabolic studies support the conclusion that no change in plasma HDL levels occurs during polyunsaturated fat feeding. 41 ' ^ In the studies in which HDL concentrations fell, similar or greater reductions in the concentrations of LDL also occurred, so that the LDL:HDL ratio remained fairly constant.…”

Section: Plasma Llpoprotelns and Apollpoproteinssupporting

confidence: 67%

Polyunsaturated fatty acids, hyperlipidemia, and thrombosis.

Goodnight¹,

Harris

Connor³

et al. 1982

Arteriosclerosis

654

150

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Section: Plasma Llpoprotelns and Apollpoproteinssupporting

confidence: 67%

Polyunsaturated fatty acids, hyperlipidemia, and thrombosis.

Goodnight¹,

Harris

Connor³

et al. 1982

Arteriosclerosis

654

150

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“…Sterol balance studies have been performed to evaluate the effects of the composition of the diet on sterol excretion (Connor et al, 1969;Grundy and Ahrens, 1969;Nestel et al, 1975). These metabolic ward investigations were elaborate, but owing to variations in bacterial degradation of the sterol ring structure in the large intestine, and variations in colonic transit time, precision was insufficient to settle the question of the effects of different diets on sterol excretion (Andersson and Bosaeus, 1993).…”

Section: Introductionmentioning

confidence: 99%

Oat bran rapidly increases bile acid excretion and bile acid synthesis: an ileostomy study

2007

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Objective: To study whether oat bran with native b-glucans increases bile acid excretion and bile acid synthesis as measured by serum concentrations of 7a-hydroxy-4-cholesten-3-one (7a-HC). Design: Short-term interventional crossover study evaluating cholesterol absorption, ileal excretion of cholesterol and bile acids, and serum levels of cholesterol and bile acid metabolites. Differences between diets evaluated with Wilcoxon's signed rank-sum test.Setting: Outpatients at a metabolic-ward kitchen. Subjects: Nine volunteers with conventional ileostomies. Methods: Two 3-day-diet periods, with controlled, blinded basal diet including 75 g extruded oat bran breakfast cereal daily, with either 11.6 g native or hydrolysed b-glucans. Results: Native oat bran increased median excretion of bile acids by 144% (P ¼ 0.008). Cholesterol excretion remained unchanged, cholesterol absorption decreased by 19% (P ¼ 0.013), whereas the sum of bile acid and cholesterol excretion increased by 40% (P ¼ 0.008) compared with hydrolysed oat bran. 7a-HC reflecting bile acid synthesis increased by 57% (P ¼ 0.008) within 24 h of consumption, whereas serum lathosterol concentration reflecting cholesterol synthesis increased by 12% (P ¼ 0.015). Conclusions: Oat bran with native b-glucans increases bile acid excretion within 24 h of consumption and this increase can also be detected by rising serum concentrations of 7a-HC. Thus, 7a-HC could be used for rapid detection of dietary effects on bile acid metabolism. These effects could possibly be explained by entrapment of whole micelles in the gut owing to higher viscosity.

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“…1) (Chevallier, 1967 ;Lutton, 1976). The,results in the literature are conflicting, but most studies in man (Moore et al, 1968 ;Connor et al, 1969 ;Nestel, Havenstein and Whyte, 1973 ;Nestel et al, 1975) and in rat (Danielsson and Tchen, 1968) , a relationship between cholesterol synthesis (m s y) and the absorption coefficient was established (25 groups of rats out of 30 assessed as « typical » rats).…”

mentioning

confidence: 99%