Increased Stem Cell Response to Erythropoietin Induced by Androgens

Urinary 17-Ketosteroids in Cystic Fibrosis

“…The Wolffian differentiation is one of the few known sites where androgen action is not attributed to 5a-dihydrotestosterone activity, another one being erythropoiesis (33), where the normally inactive 5P-metabolites of testosterone are active stimulators. In relation to this we find it remarkable that adequate dolycythemic response is seldom seen in CF patients in spite of severe cardio-pulmonary involvement (34).…”

Pathogenesis of Endocrine Abnormalities in Uremia*

“…The extrarenal production sites of the hormone seem to retain their responsiveness to hypoxia and plethora, as evidenced by reticulocytosis after hemorrhage or reduction in marrow erythroblasts after transfusion (150). Furthermore, the administration of androgens to such patients frequently augments red cell mass and, allegedly, erythropoietic activity (138), although considerable controversy exists regarding their effects on iron incorporation in the in vitro systems used for these measurements (151,152).…”

Serum Erythropoietin Concentration in Anephric Patients

“…Since a direct stimulation of hemopoietic cells by androgens could be demonstrated [10,11], such an Ep independent effect of testosterone present in the test serum on fetal mouse liver cells used in our assay had to be excluded. Three series of experiments were performed: Erythropoietin, m U /m l T e sto ste ro n e T h e rap y T e sto ste ro n e Therapy Fig.…”