Increased SS bonds in chronic solar elastosis: a study with N-(7-dimethylamino-4-methyl-3-coumarinyl) maleimide (DACM) stain

Pravatà, G; Noto, Giuseppe; Aricò, Mario

doi:10.1016/0923-1811(94)90017-5

Cited by 3 publications

(1 citation statement)

References 39 publications

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“…Compared with the non-elastic fibre associated proteins (collagen: I, III, IV, V, VI, VII, VIII, XII, XIII, XIV, XVI, XVII, XXII and XXIII; the proteoglycans: fibromodulin, decorin, biglycan, perlecan, agrin, versican and aggrecan; and the glycoproteins: thrombospondin-1 and −2, tenascin-C and –X, osteopontin, fibronectin, laminin-5 and −6, vitronectin) elastic fibre components in general (MAGP-1 and −2, LTBP-1 and −2, MFAP-1, elastin, LOX, LOXL1, 2, 3 and 4, Fibulin-1, -2 and −3, emilin-1 and EBP) and the fibrillins in particular, are enriched in Cys residues. Furthermore, most of these in latter proteins are associated with the disulphide bonded microfibrils which are: i) degraded in the papillary dermis of mildly photoaged skin and ii) abundantly distributed in the elastotic material which characterises the deeper dermis of severely photoaged skin [34,74]. In contrast, the major structural components: dermal fibrillar collagen and elastin are almost devoid of UVR sensitive amino acids (Cys and His, Phe, Trp and Tyr residues).…”

Section: Amino Acid Composition As a Predictor Of Uvr Susceptibilitymentioning

confidence: 99%

Chemical consequences of cutaneous photoageing

Thurstan

Gibbs

Langton

et al. 2012

Chemistry Central Journal

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Human skin, in common with other organs, ages as a consequence of the passage of time, but in areas exposed to solar ultraviolet radiation, the effects of this intrinsic ageing process are exacerbated. In particular, both the severity and speed of onset of age-related changes, such as wrinkle formation and loss of elasticity, are enhanced in photoaged (also termed extrinsically aged) as compared with aged, photoprotected, skin. The anatomy of skin is characterised by two major layers: an outer, avascular, yet highly cellular and dynamic epidermis and an underlying vascularised, comparatively static and cell-poor, dermis. The structural consequences of photoageing are mainly evident in the extracellular matrix-rich but cell-poor dermis where key extracellular matrix proteins are particularly susceptible to photodamage. Most investigations to date have concentrated on the cell as both a target for and mediator of, ultraviolet radiation-induced photoageing. As the main effectors of dermal remodelling produced by cells (extracellular proteases) generally have low substrate specificity, we recently suggested that the differential susceptibility of key extracellular matrix proteins to the processes of photoageing may be due to direct, as opposed to cell-mediated, photodamage.In this review, we discuss the experimental evidence for ultraviolet radiation (and related reactive oxygen species)-mediated differential degradation of normally long lived dermal proteins including the fibrillar collagens, elastic fibre components, glycoproteins and proteoglycans. Whilst these components exhibit highly diverse primary and hence macro- and supra-molecular structures, we present evidence that amino acid composition alone may be a useful predictor of age-related protein degradation in both photoexposed and, as a consequence of differential oxidation sensitivity, photoprotected, tissues.

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Section: Amino Acid Composition As a Predictor Of Uvr Susceptibilitymentioning

confidence: 99%

Chemical consequences of cutaneous photoageing

Thurstan

Gibbs

Langton

et al. 2012

Chemistry Central Journal

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Photoaging from an oxidative standpoint

Miyachi

1995

Journal of Dermatological Science

112

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P53 expression in altered limbal basal cells of pingueculae, pterygia, and limbal tumors

Dushku

Reid

1997

Current Eye Research

131

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The finding of increased nuclear p53 in the limbal epithelium of pterygia, limbal tumors, and most pingueculae indicates the probable existence of p53 mutations in these cells as an early event in their development, which is consistent with their causation by UV radiation causation. In addition, due to a damaged p53-dependent programmed cell death mechanism, mutations in other genes are progressively acquired which allows the multi-step development of pterygia and limbal tumor cells from p53 positive cells overlying a Stage II pinguecula. Similarly, a pterygium dysplasia could arise from a pterygium cell. A classification for limbal basal cell tumors is proposed, and the different stromal changes in pingueculae, pterygia, and limbal tumors are identified. Two cell types were also identified: a p53-positive pinguecula limbal epithelial cell (a pinguecula II cell) and a p53-positive pterygium dysplasia cell (pterygium dysplasia cell).

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Increased SS bonds in chronic solar elastosis: a study with N-(7-dimethylamino-4-methyl-3-coumarinyl) maleimide (DACM) stain

Cited by 3 publications

References 39 publications

Chemical consequences of cutaneous photoageing

Chemical consequences of cutaneous photoageing

Photoaging from an oxidative standpoint

P53 expression in altered limbal basal cells of pingueculae, pterygia, and limbal tumors

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